Samih H. Nasr
Mayo Clinic
PathologyBiopsyKidney diseaseKidneyMedicine
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Publications 188
#1Samih H. Nasr (Mayo Clinic)H-Index: 45
#2Jeffrey B. Kopp (NIH: National Institutes of Health)H-Index: 71
#1Sanjeev M Sethi (Mayo Clinic)H-Index: 46
#2Cynthia C. Nast (Cedars-Sinai Medical Center)H-Index: 42
Last. Fernando G Cosio (Mayo Clinic)H-Index: 37
view all 30 authors...
#1Samar M. Said (Mayo Clinic)H-Index: 13
#2Nelson Leung (Mayo Clinic)H-Index: 53
Last. Samih H. Nasr (Mayo Clinic)H-Index: 45
view all 10 authors...
Abstract The association of fibrillary glomerulonephritis (FGN) with monoclonal gammopathy has been controversial, although monotypic FGN is currently classified as a monoclonal gammopathy of renal significance (MGRS) lesion. To define this lesion, we correlated findings by immunofluorescence on frozen and paraffin tissue, IgG subtype staining and serum protein electrophoresis with immunofixation in patients with monotypic FGN. Immunofluorescence was performed on paraffin sections from 35 cases ...
#1Royal (Hôpital Maisonneuve-Rosemont)
#2Nelson Leung (Mayo Clinic)H-Index: 53
Last. Anna Maria AsunisH-Index: 3
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Light chain cast nephropathy (LCCN) in multiple myeloma often leads to severe and poorly reversible acute kidney injury. Severe renal impairment influences the allocation of chemotherapy, its tolerability, and affects patient survival. Whether renal biopsy findings add to the clinical assessment in predicting renal and patient outcomes in LCCN is uncertain. We retrospectively reviewed clinical presentation, chemotherapy regimens, hematologic response, renal and patient outcomes in 178 patients w...
#1Samih H. Nasr (Mayo Clinic)H-Index: 45
Last. Frank Bridoux (University of Limoges)H-Index: 30
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Abstract IgG (mainly IgG3) is the most commonly involved isotype in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Here we describe the first series of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-light chain). This multicenter cohort of 17 patients presented with nephritic or nephrotic syndrome with underlying hematologic conditions of monoclonal gammopathy of renal significance (71%) or multiple myeloma (29%). Monoclonal immun...
#1Alessia Buglioni (Mayo Clinic)H-Index: 5
#2Mary E. Fidler (Mayo Clinic)H-Index: 31
Last. Lynn D. Cornell (Mayo Clinic)H-Index: 38
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Pauci-immune glomerulonephritis in the native kidney presents with renal insufficiency, proteinuria, and hematuria, and is usually due to anti-neutrophil cytoplasmic antibodies. Rarely, kidney transplants can show this pattern as de novo disease. We performed a retrospective analysis in 10 cases of de novo pauci-immune glomerulonephritis. The mean time from transplant to diagnostic biopsy was 32 months (range, 4–96). All biopsies showed focal necrotizing or crescentic glomerulonephritis (mean 16...
#1Cindy Varga (Tufts Medical Center)H-Index: 5
#2Viji Nair (UM: University of Michigan)H-Index: 23
Last. Raymond L. Comenzo (Tufts Medical Center)H-Index: 48
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#1Samih H. Nasr (Mayo Clinic)H-Index: 45
#2Edgard WehbeH-Index: 6
Last. Paul J. Kurtin (Mayo Clinic)H-Index: 64
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Acute kidney injury is common in patients with cancer and may result from sepsis, obstruction, radiotherapy, chemotherapeutic agents, and nonsteroidal anti-inflammatory drugs. Rare reports of acute kidney injury due to cast nephropathy in patients with pancreatic acinar cell carcinoma have been described, but a pathogenetic link between cast nephropathy and carcinoma was not established. We report a patient with pancreatic mixed acinar-neuroendocrine carcinoma who developed severe acute kidney i...
#1Cindy VargaH-Index: 5
#2Viji NairH-Index: 23
Last. Raymond L. ComenzoH-Index: 48
view all 9 authors...
#1Maria L. Gonzalez Suarez (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Pingchuan Zhang (Mayo Clinic)H-Index: 1
Last. Nelson Leung (Mayo Clinic)H-Index: 53
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Immunoglobulin light chain amyloidosis is the most frequent type of renal amyloidosis in the United States, accounting for 81% of cases. Accurate typing is crucial for early diagnosis and treatment of immunoglobulin-derived amyloidosis and to avoid treating other amyloidoses with potentially toxic chemotherapy. Immunofluorescence is the first step to type renal immunoglobulin-derived amyloidosis but the performance characteristics of this method are largely unknown. Here, we establish the sensit...