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Samih H. Nasr
Mayo Clinic
179Publications
45H-index
5,978Citations
Publications 179
Newest
#1Barbora Sporinova (U of C: University of Calgary)
#2Susanna A. McRae (UBC: University of British Columbia)
Last.Hallgrimur Benediktsson (U of C: University of Calgary)H-Index: 22
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Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30–60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-G...
#1Samih H. Nasr (Mayo Clinic)H-Index: 45
#2Edgard WehbeH-Index: 6
Last.Paul J. Kurtin (Mayo Clinic)H-Index: 64
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Acute kidney injury is common in patients with cancer and may result from sepsis, obstruction, radiotherapy, chemotherapeutic agents, and nonsteroidal anti-inflammatory drugs. Rare reports of acute kidney injury due to cast nephropathy in patients with pancreatic acinar cell carcinoma have been described, but a pathogenetic link between cast nephropathy and carcinoma was not established. We report a patient with pancreatic mixed acinar-neuroendocrine carcinoma who developed severe acute kidney i...
#1Maria Lourdes Gonzalez Suarez (UMMC: University of Mississippi Medical Center)H-Index: 1
#2Pingchuan Zhang (Mayo Clinic)H-Index: 1
Last.Joseph Peter Grande (Mayo Clinic)H-Index: 65
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Immunoglobulin light chain (AL) amyloidosis is the most frequent type of renal amyloidosis in the United States, accounting for 81% of cases. Accurate typing is crucial for early diagnosis and treatment of immunoglobulin-derived (AIg) amyloidosis and to avoid treating other amyloidoses with potentially toxic chemotherapy. Immunofluorescence (IF) is the first step to type renal AIg amyloidosis but the performance characteristics of this method are largely unknown. Here, we establish the sensitivi...
#1Atreyee Basu (NYU: New York University)
#2Nicole J. Boczek (Mayo Clinic)H-Index: 14
Last.Cynthia C. Morton (Broad Institute)H-Index: 82
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Pathogenic variants in COCH, encoding cochlin, cause DFNA9 deafness disorder with characteristic histopathologic findings of cochlin deposits in the inner and middle ears. Here, we present the first case of deafness associated with bilateral external auditory canal (EAC) cochlin deposits, previously unreported evidence suggestive of cochlin-derived amyloid formation, and a novel COCH variant. A 54-year-old woman presented with progressive sensorineural hearing loss and bilateral EAC narrowing by...
#1Alessia Buglioni (Mayo Clinic)H-Index: 5
#2Mary E. Fidler (Mayo Clinic)H-Index: 30
Last.Lynn D. Cornell (Mayo Clinic)H-Index: 41
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Pauci-immune glomerulonephritis in the native kidney presents with renal insufficiency, proteinuria, and hematuria, and is usually due to anti-neutrophil cytoplasmic antibodies. Rarely, kidney transplants can show this pattern as de novo disease. We performed a retrospective analysis in 10 cases of de novo pauci-immune glomerulonephritis. The mean time from transplant to diagnostic biopsy was 32 months (range, 4–96). All biopsies showed focal necrotizing or crescentic glomerulonephritis (mean 16...
#1Samih H. Nasr (Mayo Clinic)H-Index: 45
#2Agnes B. Fogo (VUMC: Vanderbilt University Medical Center)H-Index: 86
Fibrillary glomerulonephritis is a glomerular disease historically defined by glomerular deposition of Congo red–negative, randomly oriented straight fibrils that lack a hollow center and stain with antisera to immunoglobulins. It was initially considered to be an idiopathic disease, but recent studies highlighted association in some cases with autoimmune disease, malignant neoplasm, or hepatitis C viral infection. Prognosis is poor with nearly half of patients progressing to end-stage renal dis...
#1Samih H. Nasr (Mayo Clinic)H-Index: 45
#2Christophe Sirac (University of Limoges)H-Index: 14
Last.Mariam P. Alexander (Mayo Clinic)H-Index: 11
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Heavy chain amyloidosis and heavy chain deposition disease are the only known kidney diseases caused by the deposition of truncated immunoglobulin heavy chains. Fibrillary glomerulonephritis typically results from deposition of DNAJB9 (DnaJ heat shock protein family [Hsp40] member B9) and polytypic immunoglobulin G (IgG). We describe a patient with monoclonal gammopathy (IgG with λ light chain) who developed DNAJB9-negative fibrillary glomerulonephritis leading to end-stage kidney disease, with ...
Background:proliferative glomerulonephritis with monoclonal immunoglobulin (Ig) deposits (PGNMID) is a distinct form of glomerulonephritis (GN) that often recurs after kidney transplantation causing severe graft injury and often failure.Methods:we describe post-transplant outcomes and response to th
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