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S Parish
Medical Research Council
154Publications
55H-index
27.6kCitations
Publications 154
Newest
Published on May 1, 2019in The Lancet 53.25
Iona Y. Millwood15
Estimated H-index: 15
(Medical Research Council),
Robin G Walters1
Estimated H-index: 1
(Medical Research Council)
+ 18 AuthorsRuying Hu10
Estimated H-index: 10
(Centers for Disease Control and Prevention)
Summary Background Moderate alcohol intake has been associated with reduced cardiovascular risk in many studies, in comparison with abstinence or with heavier drinking. Studies in east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect alcohol drinking patterns. We used these two variants to assess the relationships between cardiovascular risk and genotype-predicted mean alcohol intake in men, contrasting the findings in men with those...
1 Citations Source Cite
Published on Apr 1, 2019in Nature Medicine 32.62
L Sun1
Estimated H-index: 1
(Clinical Trial Service Unit),
Robert Clarke109
Estimated H-index: 109
(Clinical Trial Service Unit)
+ 14 AuthorsYiping Chen24
Estimated H-index: 24
(University of Oxford)
Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2. Stroke incidence and ICH proportion are higher in China than in Western populations3–5, despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of ...
1 Citations Source Cite
Published on Mar 1, 2019in Kidney International 8.43
Iryna Schlackow8
Estimated H-index: 8
(University of Oxford),
Seamus Kent7
Estimated H-index: 7
(University of Oxford)
+ 60 AuthorsColin Baigent60
Estimated H-index: 60
(Medical Research Council)
Statin-based treatments reduce cardiovascular disease (CVD) risk in patients with non-dialysis chronic kidney disease (CKD), but it is unclear which regimen is the most cost-effective. We used the Study of Heart and Renal Protection (SHARP) CKD-CVD policy model to evaluate the effect of statins and ezetimibe on quality-adjusted life years (QALYs) and health care costs in the United States (US) and the United Kingdom (UK). Net costs below $100,000/QALY (US) or £20,000/QALY (UK) were considered co...
Source Cite
Published on Mar 1, 2019
Alison Offer9
Estimated H-index: 9
(Clinical Trial Service Unit),
M Arnold1
Estimated H-index: 1
(Clinical Trial Service Unit)
+ 11 AuthorsMartin J. Landray32
Estimated H-index: 32
(Clinical Trial Service Unit)
Importance Acquisition of reliable randomized clinical trial evidence of the effects of cardiovascular interventions on cognitive decline is a priority. Objectives To estimate the association of cognitive aging with the avoidance of vascular events in cardiovascular intervention trials and understand whether reports of nonsignificant results exclude worthwhile benefit. Design, Setting, and Participants This secondary analysis of 3 randomized clinical trials in participants with preexisting occlu...
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Published on Feb 20, 2019in Neurology 8.05
Elsa Valdes-Marquez4
Estimated H-index: 4
,
S Parish55
Estimated H-index: 55
+ 3 AuthorsJemma C. Hopewell38
Estimated H-index: 38
Objective To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach. Methods We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate t...
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Published on Feb 1, 2019in The Lancet 53.25
Jane Armitage46
Estimated H-index: 46
,
Colin Baigent60
Estimated H-index: 60
+ 96 AuthorsChristopher P. Cannon131
Estimated H-index: 131
Summary Background Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages. Methods In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatment dur...
15 Citations Source Cite
Published on Oct 18, 2018in The New England Journal of Medicine 79.26
Louise Bowman15
Estimated H-index: 15
,
Marion Mafham9
Estimated H-index: 9
+ 24 AuthorsJane Armitage46
Estimated H-index: 46
© 2018 Massachusetts Medical Society. Background: Increased intake of n-3 fatty acids has been associated with a reduced risk of cardiovascular disease in observational studies, but this finding has not been confirmed in randomized trials. It remains unclear whether n-3 (also called omega-3) fatty acid supplementation has cardiovascular benefit in patients with diabetes mellitus. Methods: We randomly assigned 15,480 patients with diabetes but without evidence of atherosclerotic cardiovascular di...
28 Citations
Published on Oct 18, 2018in The New England Journal of Medicine 79.26
Louise Bowman15
Estimated H-index: 15
,
Marion Mafham9
Estimated H-index: 9
+ 24 AuthorsJane Armitage46
Estimated H-index: 46
© 2018 Massachusetts Medical Society. Background: Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. Methods: We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive aspirin at a dose of 100 mg daily or matching pl...
55 Citations
Published on Jun 1, 2018in The Lancet Global Health 18.70
Zhengming Chen46
Estimated H-index: 46
,
Andri Iona6
Estimated H-index: 6
+ 11 AuthorsBen Lacey6
Estimated H-index: 6
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