S Parish
University of Oxford
149Publications
54H-index
27.1kCitations
Publications 149
Newest
Published on Mar 11, 2019in Nature Medicine 32.62
Luanluan Sun (Clinical Trial Service Unit), Robert Clarke84
Estimated H-index: 84
(Clinical Trial Service Unit)
+ 14 AuthorsYiping Chen20
Estimated H-index: 20
(University of Oxford)
Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2. Stroke incidence and ICH proportion are higher in China than in Western populations3–5, despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of ...
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Published on Feb 1, 2019in The Lancet 53.25
Jane Armitage46
Estimated H-index: 46
,
Colin Baigent56
Estimated H-index: 56
+ 96 AuthorsChristopher P. Cannon130
Estimated H-index: 130
Summary Background Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety among older people. We undertook a meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages. Methods In this meta-analysis, randomised trials of statin therapy were eligible if they aimed to recruit at least 1000 participants with a scheduled treatment dur...
7 Citations Source Cite
Published on Feb 20, 2019in Neurology 8.05
Elsa Valdes-Marquez3
Estimated H-index: 3
,
S Parish54
Estimated H-index: 54
+ 3 AuthorsJemma C. Hopewell37
Estimated H-index: 37
Objective To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach. Methods We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate t...
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Published on Mar 1, 2019in Kidney International 8.43
Iryna Schlackow8
Estimated H-index: 8
(University of Oxford),
Seamus Kent7
Estimated H-index: 7
(University of Oxford)
+ 60 AuthorsColin Baigent56
Estimated H-index: 56
(Medical Research Council)
Statin-based treatments reduce cardiovascular disease (CVD) risk in patients with non-dialysis chronic kidney disease (CKD), but it is unclear which regimen is the most cost-effective. We used the Study of Heart and Renal Protection (SHARP)CKD-CVD policy model to evaluate the effect of statins and ezetimibe on quality-adjusted life years (QALYs) and healthcare costs in the United States (US) and the United Kingdom (UK). Net costs below $100,000/QALY (US) or £20,000/QALY (UK) were considered cost...
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Published on Oct 18, 2018in The New England Journal of Medicine 79.26
Louise Bowman15
Estimated H-index: 15
,
Marion Mafham8
Estimated H-index: 8
+ 24 AuthorsJane Armitage46
Estimated H-index: 46
© 2018 Massachusetts Medical Society. Background: Increased intake of n-3 fatty acids has been associated with a reduced risk of cardiovascular disease in observational studies, but this finding has not been confirmed in randomized trials. It remains unclear whether n-3 (also called omega-3) fatty acid supplementation has cardiovascular benefit in patients with diabetes mellitus. Methods: We randomly assigned 15,480 patients with diabetes but without evidence of atherosclerotic cardiovascular di...
16 Citations
Published on May 2, 2018in PLOS Medicine 11.68
Ling Lu1
Estimated H-index: 1
(Chinese Academy of Sciences),
David A. Bennett149
Estimated H-index: 149
(Clinical Trial Service Unit)
+ 15 AuthorsMichael V. Holmes28
Estimated H-index: 28
(University of Oxford)
Background Observational studies have reported that higher plasma 25-hydroxyvitamin D (25[OH]D) concentrations are associated with lower risks of diabetes, but it is unclear if these associations are causal. The aim of this study was to test the relevance of 25(OH)D for type 2 diabetes using genetically instrumented differences in plasma 25(OH)D concentrations. Methods and findings Data were available on four 25(OH)D single nucleotide polymorphisms (SNPs; n = 82,464), plasma 25(OH)D concentratio...
4 Citations Source Cite
Published on Feb 1, 2018in Journal of the American College of Cardiology 16.83
Michael V. Holmes28
Estimated H-index: 28
,
Iona Y. Millwood16
Estimated H-index: 16
+ 16 AuthorsRuying Hu9
Estimated H-index: 9
Kadoorie Charitable Foundation; UK Wellcome Trust: 202922/Z/16/Z, 088158/Z/09/Z, 104085/Z/14/Z; National Key Research and Development Program of China: 2016YFC0900500, 2016YFC0900501, 2016YFC0900504; Chinese Ministry of Science and Technology: 2011BAI09B01; National Natural Science Foundation of China: 81390540, 81390541, 81390544; BHF Centre of Research Excellence, Oxford: RE/13/1/30181
12 Citations Source Cite
Published on Jun 1, 2018in The Lancet Global Health 18.70
Zhengming Chen43
Estimated H-index: 43
(Clinical Trial Service Unit),
Andri Iona6
Estimated H-index: 6
(Clinical Trial Service Unit)
+ 166 AuthorsSarah Lewington41
Estimated H-index: 41
(Medical Research Council)
Summary Background China has high stroke rates despite the population being relatively lean. Uncertainty persists about the relevance of adiposity to risk of stroke types. We aimed to assess the associations of adiposity with incidence of stroke types and effect mediation by blood pressure in Chinese men and women. Methods The China Kadoorie Biobank enrolled 512 891 adults aged 30–79 years from ten areas (five urban and five rural) during 2004–08. During a median 9 years (IQR 8–10) of follow-up,...
1 Citations Source Cite
Published on Jun 1, 2018in The Lancet Global Health 18.70
Zhengming Chen43
Estimated H-index: 43
,
Andri Iona6
Estimated H-index: 6
+ 11 AuthorsBen Lacey6
Estimated H-index: 6
Published on Oct 18, 2018in The New England Journal of Medicine 79.26
Louise Bowman15
Estimated H-index: 15
,
Marion Mafham8
Estimated H-index: 8
+ 24 AuthorsJane Armitage46
Estimated H-index: 46
© 2018 Massachusetts Medical Society. Background: Diabetes mellitus is associated with an increased risk of cardiovascular events. Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; the balance of benefits and hazards for the prevention of first cardiovascular events in patients with diabetes is unclear. Methods: We randomly assigned adults who had diabetes but no evident cardiovascular disease to receive aspirin at a dose of 100 mg daily or matching pl...
36 Citations
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