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S Parish
Medical Research Council
156Publications
55H-index
27.6kCitations
Publications 156
Newest
#1Richard Haynes (University of Oxford)H-Index: 15
#2Elsa Valdes-Marquez (Clinical Trial Service Unit)H-Index: 4
Last.Yale B. MitchelH-Index: 34
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Abstract Purpose The Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial of patients at high risk of vascular disease found that adding extended-release niacin-laropiprant to intensive statin-based LDL-lowering therapy had no benefit on cardiovascular outcomes. However, the trial also identified previously unrecognized serious adverse effects (including new-onset diabetes, bleeding, and infection). Our objective was to explore the safety profi...
#1M Arnold (Clinical Trial Service Unit)H-Index: 1
#2Andrew Linden (Clinical Trial Service Unit)
Last.Yuexin Chen (Peking Union Medical College Hospital)
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Background Lean body mass has been identified as a key determinant of left ventricular mass and wall thickness. However, the importance of lean body mass or other body‐size measures as normative de...
#1S Parish (Medical Research Council)H-Index: 55
#2M Arnold (Clinical Trial Service Unit)H-Index: 1
Last.Rory Collins (Clinical Trial Service Unit)H-Index: 131
view all 12 authors...
Importance A better understanding of the role of atherosclerosis in the development of ischemic stroke subtypes could help to improve strategies for prevention of stroke worldwide. Objective To assess the role of carotid atherosclerosis in the association between major cardiovascular risk factors and ischemic stroke subtypes. Design, Setting, and Participants The prospective China Kadoorie Biobank cohort study was conducted in the general population of 5 urban and 5 rural areas in China, with a ...
#1Iona Y. Millwood (Medical Research Council)H-Index: 15
#2Robin G Walters (Medical Research Council)H-Index: 1
Last.Ruying Hu (CDC: Centers for Disease Control and Prevention)H-Index: 10
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Summary Background Moderate alcohol intake has been associated with reduced cardiovascular risk in many studies, in comparison with abstinence or with heavier drinking. Studies in east Asia can help determine whether these associations are causal, since two common genetic variants greatly affect alcohol drinking patterns. We used these two variants to assess the relationships between cardiovascular risk and genotype-predicted mean alcohol intake in men, contrasting the findings in men with those...
#1L Sun (Clinical Trial Service Unit)H-Index: 1
#2Robert Clarke (Clinical Trial Service Unit)H-Index: 109
Last.Zheng Bian (Academy of Medical Sciences, United Kingdom)H-Index: 15
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Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2. Stroke incidence and ICH proportion are higher in China than in Western populations3–5, despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of ...
#1Alison Offer (Clinical Trial Service Unit)H-Index: 9
#2M Arnold (Clinical Trial Service Unit)H-Index: 1
Last.Jing Li (Peking Union Medical College)
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Importance Acquisition of reliable randomized clinical trial evidence of the effects of cardiovascular interventions on cognitive decline is a priority. Objectives To estimate the association of cognitive aging with the avoidance of vascular events in cardiovascular intervention trials and understand whether reports of nonsignificant results exclude worthwhile benefit. Design, Setting, and Participants This secondary analysis of 3 randomized clinical trials in participants with preexisting occlu...
#2S ParishH-Index: 55
Last.Jemma C. HopewellH-Index: 38
view all 6 authors...
Objective To examine the causal relevance of lifelong differences in low-density lipoprotein cholesterol (LDL-C) for ischemic stroke (IS) relative to that for coronary heart disease (CHD) using a Mendelian randomization approach. Methods We undertook a 2-sample Mendelian randomization, based on summary data, to estimate the causal relevance of LDL-C for risk of IS and CHD. Information from 62 independent genetic variants with genome-wide significant effects on LDL-C levels was used to estimate t...
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