Christine Marie Ladd-Acosta
Johns Hopkins University
DNA methylationAutism spectrum disorderEpigeneticsGeneticsBiology
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Publications 56
#1Kristen Lyall (Drexel University)H-Index: 17
#2Lanxin Song (Johns Hopkins University)
Last. Christine Marie Ladd-Acosta (Johns Hopkins University)H-Index: 23
view all 19 authors...
Advanced parental age is a well-replicated risk factor for autism spectrum disorder (ASD), a neurodevelopmental condition with a complex and not well-defined etiology. We sought to determine parental age associations with ASD-related outcomes in subjects at high familial risk for ASD. A total of 397 younger siblings of a child with ASD, drawn from existing prospective high familial risk cohorts, were included in these analyses. Overall, we did not observe significant associations of advanced par...
#1Jonathan A. Hollander (NIH: National Institutes of Health)
Last. Mady Hornig-RohanH-Index: 40
view all 18 authors...
The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking neuropsychiatric disorders to genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure and schizophrenia) have, in contrast, lagged behind heritable frameworks of explanation. Thus, the association of neuropsychiatric illness to environmental chemical exposure, a...
#1Caitlin G. HoweH-Index: 6
#2Bianca CoxH-Index: 21
Last. Anne P. StarlingH-Index: 12
view all 38 authors...
#1Laura A. McGuinnH-Index: 7
#2Gayle C. WindhamH-Index: 37
Last. Julie L. DanielsH-Index: 22
view all 16 authors...
Background:Epidemiologic studies have reported associations between prenatal and early postnatal air pollution exposure and autism spectrum disorder (ASD); however, findings differ by pollutant and developmental window.Objectives:We examined associations between early life exposure to PM2.5 and ozon
2 CitationsSource
#1Caitlin G. Howe (SC: University of Southern California)H-Index: 6
#2Bianca Cox (University of Hasselt)H-Index: 21
Last. Carrie V. Breton (SC: University of Southern California)H-Index: 27
view all 38 authors...
OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation in the Pregnancy and Childhood Epigenetics (PACE) consortium. RESEARCH DESIGN AND METHODS Seven pregnancy cohorts (3,677 mother-newborn pairs [317 w...
#1Amy E. Kalkbrenner (UWM: University of Wisconsin–Milwaukee)H-Index: 14
#2Sandra M. Meier (Lundbeck)H-Index: 9
Last. Diana E. Schendel (AU: Aarhus University)H-Index: 41
view all 7 authors...
#1Priya Duggal (Johns Hopkins University)H-Index: 32
#2Christine Marie Ladd-Acosta (Johns Hopkins University)H-Index: 23
Last. Terri H. Beaty (Johns Hopkins University)H-Index: 65
view all 4 authors...
#1Phil H. LeeH-Index: 39
#2Verneri AnttilaH-Index: 31
Last. Jordan W. SmollerH-Index: 78
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Summary Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. ...
30 CitationsSource
#1Christine Marie Ladd-Acosta (Johns Hopkins University)H-Index: 23
#2M. Daniele Fallin (Johns Hopkins University)H-Index: 26
1 CitationsSource
#1Elisabeth Conradt (UofU: University of Utah)H-Index: 13
#2Tess FlanneryH-Index: 1
Last. Barry M. Lester (Brown University)H-Index: 61
view all 21 authors...
Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000 births in 2000 to 5.8 per 1000 births in 2012. Symptoms in neonates may include high-pitched cry, tremors, feeding difficulty, hypertonia, watery stools, and breathing problems. However, little is known about the neurodevelopmental consequences of prenatal opioid exposure in infancy, early childhood, and middle childhood. Even less is known about the cognitive, behavioral, and academic outcomes of children who d...
1 CitationsSource