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Ulf Smith
University of Gothenburg
EndocrinologyAdipose tissueInsulin resistanceInsulinDiabetes mellitus
408Publications
84H-index
26.7kCitations
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Publications 404
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#1Jagadish Vangipurapu (University of Eastern Finland)H-Index: 11
#2Lilian Fernandes Silva (University of Eastern Finland)
Last. Mauri Laakso (University of Eastern Finland)H-Index: 139
view all 5 authors...
OBJECTIVE Recent studies have highlighted the significance of the microbiome in human health and disease. Changes in the metabolites produced by microbiota have been implicated in several diseases. Our objective was to identify microbiome metabolites that are associated with type 2 diabetes. RESEARCH DESIGN AND METHODS 5,181 participants from the cross-sectional Metabolic Syndrome in Men (METSIM) study that included Finnish men (age 57 ± 7 years, BMI 26.5 ± 3.5 kg/m2) having metabolomics data av...
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#1Shahram Hedjazifar (University of Gothenburg)H-Index: 10
#2Roxana Khatib Shahidi (University of Gothenburg)H-Index: 1
Last. Ulf Smith (University of Gothenburg)H-Index: 84
view all 8 authors...
The BMP2/4 antagonist and novel adipokine, Gremlin 1, is highly expressed in human adipose cells and increased in hypertrophic obesity. As a secreted antagonist it inhibits the effect of BMP2/4 on adipose precursor cell commitment/differentiation. We examined mRNA levels of Gremlin in key target tissues for insulin and also measured tissue and serum levels in several carefully phenotyped human cohorts. Gremlin 1 expression was high in adipose tissue, higher in visceral than in subcutaneous tissu...
1 CitationsSource
#1Jenny M. Hoffmann (University of Gothenburg)H-Index: 6
#2John R. Grünberg (University of Gothenburg)H-Index: 2
Last. Ulf Smith (University of Gothenburg)H-Index: 84
view all 12 authors...
Abstract Objective Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT) and enhancing energy expenditure. Here, we examine whether this approach could also reduce established obesity. Methods Dietary-induced obese C57BL6/N mice received AAV8 BMP4 gene therapy at 17–18 weeks of age. They were kept on a high-fat...
1 CitationsSource
#1Marita Westhrin (NTNU: Norwegian University of Science and Technology)H-Index: 5
#2Toril Holien (NTNU: Norwegian University of Science and Technology)H-Index: 15
Last. Therese Standal (NTNU: Norwegian University of Science and Technology)H-Index: 16
view all 16 authors...
Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. Bone morphogenetic protein 4 (BMP4) is important for both pre- and postnatal bone formation and induces growth arrest and apoptosis of myeloma cells. BMP4-treatment of myeloma patients could have the potential to reduce tumor growth and restore bone formation. We therefore explored BM...
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#1Sergio GhioneH-Index: 114
#2Maria I. Bokarewa (University of Gothenburg)H-Index: 34
Last. Ulf Smith (University of Gothenburg)H-Index: 84
view all 13 authors...
Abstract Mannose is a glucose-associated serum metabolite mainly released by the liver. Recent studies have shown several unexpected pleiotropic effects of mannose including increased regulatory T cells (Tregs), prevention of auto-immune disease and ability to reduce growth of human cancer cells. We have previously shown in large cohorts that elevated serum mannose levels are associated with future development of type 2 diabetes (T2D) and cardiovascular disease. However, potential direct effects...
1 CitationsSource
#1Allyson K. Palmer (Mayo Clinic)H-Index: 12
#2Birgit Gustafson (Sahlgrenska University Hospital)H-Index: 19
Last. Ulf Smith (Sahlgrenska University Hospital)H-Index: 84
view all 4 authors...
Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been described and recently entered clinical trials. In this review, we explore the biologica...
1 CitationsSource
#1Birgit Gustafson (University of Gothenburg)H-Index: 19
#2Annika Nerstedt (University of Gothenburg)H-Index: 11
Last. Ulf Smith (University of Gothenburg)H-Index: 84
view all 3 authors...
Inappropriate expansion of the adipose cells in the subcutaneous adipose tissue (SAT) is a characteristic of hypertrophic obesity and of individuals with genetic predisposition for T2D (first-degree relatives; FDR). It is associated with insulin resistance, a dysfunctional, adipose tissue and reduced adipogenesis. We examined the regulation of adipogenesis in human SAT precursor cells and found ZNF521 to be a critical regulator of early adipogenic commitment and precursor cells leaving the cell ...
1 CitationsSource
#1Mario DiGirolamoH-Index: 27
#2Ulf SmithH-Index: 84
Source
#1Jagadish Vangipurapu (University of Eastern Finland)H-Index: 11
#2Alena Stančáková (University of Eastern Finland)H-Index: 49
Last. Mauri Laakso (University of Eastern Finland)H-Index: 139
view all 5 authors...
Several amino acids have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but none of previous studies has investigated the association of amino acids with insulin secretion in a longitudinal setting. Our study included 5181 participants of the cross-sectional METabolic Syndrome In Men study having metabolomics data on twenty amino acids. A total of 4851 of them had a 4.6-year follow-up visit. Nine amino acids (phenylalanine, tryptophan, tyrosine, alanin...
3 CitationsSource
#1Marita Westhrin (NTNU: Norwegian University of Science and Technology)H-Index: 5
#2Toril Holien (NTNU: Norwegian University of Science and Technology)H-Index: 15
Last. Therese Standal (VUmc: VU University Medical Center)H-Index: 16
view all 16 authors...
Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. Bone morphogenetic protein 4 (BMP4) is important for both pre- and postnatal bone formation and induces growth arrest and apoptosis of myeloma cells. BMP4-treatment of myeloma patients could have the potential to reduce tumor growth and restore bone formation. We therefore explored BM...
Source
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