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Ulf Smith
University of Gothenburg
393Publications
83H-index
25.6kCitations
Publications 393
Newest
Published on Dec 1, 2019in Nature Communications11.88
Birgit Gustafson19
Estimated H-index: 19
(University of Gothenburg),
Annika Nerstedt10
Estimated H-index: 10
(University of Gothenburg),
Ulf Smith83
Estimated H-index: 83
(University of Gothenburg)
Inappropriate expansion of the adipose cells in the subcutaneous adipose tissue (SAT) is a characteristic of hypertrophic obesity and of individuals with genetic predisposition for T2D (first-degree relatives; FDR). It is associated with insulin resistance, a dysfunctional, adipose tissue and reduced adipogenesis. We examined the regulation of adipogenesis in human SAT precursor cells and found ZNF521 to be a critical regulator of early adipogenic commitment and precursor cells leaving the cell ...
Published on Oct 1, 2019in Diabetologia7.11
Allyson K. Palmer10
Estimated H-index: 10
(Mayo Clinic),
Birgit Gustafson19
Estimated H-index: 19
(Sahlgrenska University Hospital)
+ 1 AuthorsUlf Smith83
Estimated H-index: 83
(Sahlgrenska University Hospital)
Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. Senescent cells have been directly implicated in the generation of insulin resistance. Recently, drugs that preferentially target senescent cells, known as senolytics, have been described and recently entered clinical trials. In this review, we explore the biologica...
Published on Jun 4, 2019
Mario DiGirolamo25
Estimated H-index: 25
,
Ulf Smith83
Estimated H-index: 83
Published on Jun 1, 2019in Diabetes7.20
Jagadish Vangipurapu10
Estimated H-index: 10
(University of Eastern Finland),
Alena Stančáková46
Estimated H-index: 46
(University of Eastern Finland)
+ 2 AuthorsMauri Laakso132
Estimated H-index: 132
(University of Eastern Finland)
Several amino acids have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but none of previous studies has investigated the association of amino acids with insulin secretion in a longitudinal setting. Our study included 5181 participants of the cross-sectional METabolic Syndrome In Men study having metabolomics data on twenty amino acids. A total of 4851 of them had a 4.6-year follow-up visit. Nine amino acids (phenylalanine, tryptophan, tyrosine, alanin...
Published on Dec 1, 2018in Scientific Reports4.01
Ann Hammarstedt26
Estimated H-index: 26
(University of Gothenburg),
Ismail Syed14
Estimated H-index: 14
(Harvard University)
+ 4 AuthorsUlf Smith83
Estimated H-index: 83
(University of Gothenburg)
Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs), was discovered. These have anti-diabetic and anti-inflammatory effects in mice and are reduced in serum and adipose tissue of insulin resistant humans. In the present study, we investigate if adipose tissue dysfunction is associated with reduced PAHSA levels in human subjects and if...
Published on Oct 1, 2018in Physiological Reviews24.25
Ann Hammarstedt26
Estimated H-index: 26
(University of Gothenburg),
Silvia Gogg9
Estimated H-index: 9
(University of Gothenburg)
+ 2 AuthorsUlf Smith83
Estimated H-index: 83
(University of Gothenburg)
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids. However, it has a limited ability to expand by recruiting and/or differentiating available precursor ce...
Published on Oct 1, 2018in Cell Metabolism22.41
Ismail Syed14
Estimated H-index: 14
(BIDMC: Beth Israel Deaconess Medical Center),
Jennifer H. Lee11
Estimated H-index: 11
(BIDMC: Beth Israel Deaconess Medical Center)
+ 8 AuthorsAlan Saghatelian44
Estimated H-index: 44
(Salk Institute for Biological Studies)
Published on Jul 1, 2018in Diabetes7.20
Finnish Diabetic Nephropathy Study1
Estimated H-index: 1
(University of Oxford)
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subje...
Published on Jun 1, 2018in Nature Reviews Gastroenterology & Hepatology23.57
Adil Mardinoglu27
Estimated H-index: 27
(Chalmers University of Technology),
Jan Borén64
Estimated H-index: 64
(Sahlgrenska University Hospital)
+ 2 AuthorsJens Nielsen17
Estimated H-index: 17
(Chalmers University of Technology)
Detailed insights into the biological functions of the liver and an understanding of its crosstalk with other human tissues and the gut microbiota can be used to develop novel strategies for the prevention and treatment of liver-associated diseases, including fatty liver disease, cirrhosis, hepatocellular carcinoma and type 2 diabetes mellitus. Biological network models, including metabolic, transcriptional regulatory, protein–protein interaction, signalling and co-expression networks, can provi...
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