(VUMC: Vanderbilt University Medical Center), Xiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)+ 8 AuthorsYu-Tang Gao27
Estimated H-index: 27
(SJTU: Shanghai Jiao Tong University)
Background Trimethylamine‐N‐oxide (TMAO), a diet‐derived, gut microbial–host cometabolite, has been associated with adverse cardiovascular outcomes in patient populations; however, evidence is lacking from prospective studies conducted in general populations and non‐Western populations. Methods and Results We evaluated urinary levels of TMAO and its precursor metabolites (ie, choline, betaine, and carnitine) in relation to risk of coronary heart disease (CHD) among Chinese adults in a nested cas...
(VUMC: Vanderbilt University Medical Center)+ 8 AuthorsWei Zheng110
Estimated H-index: 110
(VUMC: Vanderbilt University Medical Center)
Epidemiologic evidence on dietary carbohydrates and stroke risk remains controversial. Very few prospective cohort studies have been conducted in Asian populations, who usually consume a high-carbohydrate diet and have a high burden of stroke.We examined dietary glycemic index (GI), glycemic load (GL), and intakes of refined and total carbohydrates in relation to risks of total, ischemic, and hemorrhagic stroke and stroke mortality.This study included 64,328 Chinese women, aged 40-70 y, with no ...
Metabolomic studies have identified several metabolites associated with type 2 diabetes (T2D) in populations of European ancestry. East Asians, a population of particular susceptibility to T2D, were generally not included in previous studies. We examined the associations of plasma metabolites with risk and prevalence of T2D in 976 Chinese men and women (40–74 years of age) who were participants of two prospective cohort studies and had no cardiovascular disease or cancer at baseline. Sixty-eight...
Asians have high prevalence of central obesity despite the low prevalence of general obesity. We evaluated associations between the central obesity measure, waist-hip ratio (WHR) with total and cause-specific mortality in middle-aged and elderly Chinese participants. Data arise from two prospective population-based cohort studies: the Shanghai Men’s Health Study involves 53,425 men (participation rate = 74.0%), age 40–74 at baseline, and the Shanghai Women’s Health Study involves 63,017 women (p...
Background: Hormone therapy has been shown to increase risk of ischemic stroke in women. Plant-derived estrogens, particularly soy isoflavones, are known to have some estrogenic effects and have been marketed as natural alternatives to hormone therapy. Concerns have been raised about whether high isoflavone exposure may be related to ischemic stroke risk as well. Objective: We examined the dietary intake of isoflavones and the urinary excretion of isoflavonoids in relation to risk of ischemic st...
Background A healthy diet, as defined by the US Dietary Guidelines for Americans (DGA), has been associated with lower morbidity and mortality from major chronic diseases in studies conducted in predominantly non-Hispanic white individuals. It is unknown whether this association can be extrapolated to African-Americans and low-income populations.
(University of Texas Health Science Center at San Antonio), Xiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)+ 11 AuthorsMark P. Purdue7
Estimated H-index: 7
(OICR: Ontario Institute for Cancer Research)
AbstractObjective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokine...
(CDC: Centers for Disease Control and Prevention)+ 7 AuthorsXiao-Ou Shu96
Estimated H-index: 96
(Vandy: Vanderbilt University)
Purpose Low bone mineral density (BMD) is common among breast cancer survivors due to acute estrogen deprivation. Soy food is a rich source of phytoestrogens, namely isoflavones, known to have both estrogenic and anti-estrogenic effects. The objective of the study was to assess the association between soy consumption and BMD in breast cancer survivors, which has not previously been evaluated.
Background: Noncommunicable diseases (NCDs) have emerged as a top threat to public health and economic growth worldwide, particularly in developing countries. Adopting healthy dietary patterns is one of the most important modifiable factors for NCD prevention. Objective: To examine whether higher adherence to the Dietary Guidelines for Chinese is associated with lower risk of developing major NCDs, including coronary heart disease (CHD), stroke, and type 2 diabetes. Design: A longitudinal analys...