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Hung Fan
University of California, Irvine
114Publications
29H-index
2,683Citations
Publications 114
Newest
#1Robert J. Gifford (Glas.: University of Glasgow)H-Index: 28
#2Jonas Blomberg (Uppsala University)H-Index: 39
Last.Welkin E. Johnson (BC: Boston College)H-Index: 27
view all 9 authors...
Retroviral integration into germline DNA can result in the formation of a vertically inherited proviral sequence called an endogenous retrovirus (ERV). Over the course of their evolution, vertebrate genomes have accumulated many thousands of ERV loci. These sequences provide useful retrospective information about ancient retroviruses, and have also played an important role in shaping the evolution of vertebrate genomes. There is an immediate need for a unified system of nomenclature for ERV loci...
11 CitationsSource
#1Mart Krupovic (Pasteur Institute)H-Index: 40
#2Jonas Blomberg (Uppsala University)H-Index: 39
Last.Jens H. Kuhn (NIH: National Institutes of Health)H-Index: 44
view all 30 authors...
Reverse-transcribing viruses, which synthesize a copy of genomic DNA from an RNA template, are widespread in animals, plants, algae and fungi (1, 2).….
18 CitationsSource
#1Mart KrupovicH-Index: 40
#2Jonas BlombergH-Index: 39
Last.Jens H. KuhnH-Index: 44
view all 30 authors...
#1Alvaro E. Galvis (UCI: University of California, Irvine)H-Index: 2
#2Hugh E. Fisher (UCI: University of California, Irvine)H-Index: 2
Last.David Camerini (UCI: University of California, Irvine)H-Index: 13
view all 4 authors...
3 CitationsSource
#1Mart KrupovicH-Index: 40
#2Balázs HarrachH-Index: 30
Last.Livia StavoloneH-Index: 10
view all 29 authors...
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#1Ignacio A. Rodriguez-Brenes (UCI: University of California, Irvine)H-Index: 9
#2Andrew Hofacre (UCI: University of California, Irvine)H-Index: 6
Last.Dominik Wodarz (UCI: University of California, Irvine)H-Index: 39
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While virus growth dynamics have been well-characterized in several infections, data are typically collected once the virus population becomes easily detectable. Earlier dynamics, however, remain less understood. We recently reported unusual early dynamics in an experimental system using adenovirus infection of human embryonic kidney (293) cells. Under identical experimental conditions, inoculation at low infection multiplicities resulted in either robust spread, or in limited spread that eventu...
6 CitationsSource
In 1970 the independent and simultaneous discovery of reverse transcriptase in retroviruses (then RNA tumor viruses) by David Baltimore and Howard Temin revolutionized molecular biology and laid the foundations for retrovirology and cancer biology. In this historical review we describe the formulation of the controversial provirus hypothesis by Temin, which ultimately was proven by his discovery of reverse transcriptase in Rous sarcoma virus virions. Baltimore arrived at the same discovery throu...
6 CitationsSource
#1TakayukiNitta (Savannah State University)H-Index: 12
#2Dat Ha (UCI: University of California, Irvine)H-Index: 2
Last.Hung Fan (UCI: University of California, Irvine)H-Index: 29
view all 5 authors...
Background Koala retrovirus (KoRV) is an endogenous and exogenous retrovirus of koalas that may cause lymphoma. As for many other gammaretroviruses, the KoRV genome can potentially encode an alternate form of Gag protein, glyco-gag.
2 CitationsSource
#1Tom Hsu (UCI: University of California, Irvine)H-Index: 1
#2An Phung (UCI: University of California, Irvine)H-Index: 1
Last.Hung Fan (UCI: University of California, Irvine)H-Index: 29
view all 5 authors...
ABSTRACT The native envelope gene ( env ) of Jaagsiekte sheep retrovirus (JSRV) also acts as an oncogene. To investigate the mechanism of transformation, we performed yeast 2-hybrid screening for cellular proteins that interact with Env. Among several candidates, we identified mouse or rat zinc finger protein 111 ( zfp111 ). The interaction between Env and Zfp111 was confirmed through in vivo coimmunoprecipitation assays. Knockdown of endogenous Zfp111 caused a decrease in cell transformation by...
3 CitationsSource
#1TakayukiNittaH-Index: 12
#2Dat HaH-Index: 2
Last.Hung FanH-Index: 29
view all 5 authors...
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