Elin S. Gray
Edith Cowan University
Publications 85
#1Lucy Barrett (UWA: University of Western Australia)H-Index: 3
#2Jason Waithman (UWA: University of Western Australia)H-Index: 11
Last.James W. Wells (UQ: University of Queensland)H-Index: 17
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Anti-programmed cell death (PD)-1/PD-ligand 1 (L1) therapies have significantly improved the outcomes for non-small cell lung cancer (NSCLC) patients in recent years. These therapies work by reactivating the immune system and enabling it to target cancer cells once more. There is a general agreement that expression of PD-L1 on tumour cells predicts the therapeutic response to PD-1/PD-L1 inhibitors in NSCLC. Hence, immunohistochemical staining of tumour tissue biopsies from NSCLC patients with PD...
#1Jesse Armitage (UWA: University of Western Australia)H-Index: 1
#2Dino B.A. Tan (UWA: University of Western Australia)H-Index: 6
Last.Yuben Moodley (UWA: University of Western Australia)H-Index: 19
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Abstract Flow cytometry provides robust, multi-parametric and quantitative information on single cells which also exhibits enormous potential as a tool for small particle characterisation. Small extracellular vesicle (sEV) detection by flow cytometry remains compromised due to the high prevalence of swarm detection, which is defined by the simultaneous illumination of more than one sEV, recorded as a single event. Detection of sEVs by imaging flow cytometry presents a major advantage by having t...
#1Elin S. Gray (ECU: Edith Cowan University)H-Index: 29
#2Tom WitkowskiH-Index: 2
Last.Athena Hatzimihalis (Peter MacCallum Cancer Centre)H-Index: 1
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The analysis of circulating tumor DNA provides a minimally invasive molecular interrogation that has the potential to guide treatment selection and disease monitoring. Here, the authors evaluated a custom UltraSEEK melanoma panel for the MassARRAY system, probing for 61 mutations over 13 genes. The analytical sensitivity and clinical accuracy of the UltraSEEK melanoma panel was compared with droplet digital PCR. The blinded analysis of 68 mutations detected in 48 plasma samples from stage IV mel...
#2Elin S. GrayH-Index: 29
Last.Mel ZimanH-Index: 11
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Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic-captured by targeting either the melanoma-associated marker, MCSP, or the melanoma-initiating marker, ABCB5. Firstly, the expression of a subset of melanoma genes was investigated by RT-PCR in MCSP-enriched and ABCB5-enriched CTCs isolated from a total of 59 blood draws from 39 melanoma cases. Of these, 6 MCSP- and 6 ABCB5-enric...
#1Ashleigh C. McEvoy (ECU: Edith Cowan University)H-Index: 4
#2Lydia Warburton (SCGH: Sir Charles Gairdner Hospital)H-Index: 2
Last.Melanie Ziman (ECU: Edith Cowan University)H-Index: 24
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Background Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metastatic disease. Therefore, there is a need to understand the correlation between ctDNA levels and the patients’ overall metabolic tumour burden (MTB).
#1Muhammad A. Khattak (Fiona Stanley Hospital)H-Index: 6
#2Elin S. Gray (ECU: Edith Cowan University)H-Index: 29
Last.Melanie Ziman (ECU: Edith Cowan University)H-Index: 24
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