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Annette Schenck
Radboud University Nijmegen
79Publications
31H-index
4,630Citations
Publications 80
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#1S.H. Merkling (Radboud University Nijmegen)
#2H. Riahi Asl (Radboud University Nijmegen)
Last.R.P. van Rij (Radboud University Nijmegen)H-Index: 3
view all 5 authors...
The fruit fly Drosophila melanogaster is a valuable model organism for the discovery and characterization of innate immune pathways, but host responses to virus infection remain incompletely understood. Here, we describe a novel player in host defense, Sgroppino (Sgp). Genetic depletion of Sgroppino causes hypersensitivity of adult flies to infections with the RNA viruses Drosophila C virus, cricket paralysis virus, and Flock House virus. Canonical antiviral immune pathways are functional in Sgr...
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#1Marieke KleinH-Index: 10
#2Euginia L. SinggihH-Index: 1
Last.Barbara FrankeH-Index: 76
view all 12 authors...
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#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Monique van der Voet (Radboud University Nijmegen)H-Index: 12
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 7 authors...
Aim: Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable psychiatric disorder. The objective of this study was to define ADHD-associated candidate genes, and their associated molecular modules and biological themes, based on the analysis of rare genetic variants. Methods: We combined data from 11 published copy number variation (CNV) studies in 6176 individuals with ADHD and 25026 controls and prioritized genes by applying an integrative strategy based on criteria including rec...
Source
#1Marieke Klein (Radboud University Nijmegen)H-Index: 10
#2Euginia L. Singgih (Radboud University Nijmegen)H-Index: 1
Last.Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 13 authors...
Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with Intellectual Disability (ID), and shared overlapping genetics have been suggested. This study aimed to identify novel ADHD genes by investigating whether genes carrying rare mutations linked to ID contribute to ADHD risk through common genetic variants. Validation and characterization of candidates were performed using Drosophila melanogaster. Method: Comm...
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#1Michaela Fenckova (Radboud University Nijmegen)H-Index: 10
#2Laura E.R. Blok (Radboud University Nijmegen)H-Index: 1
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 14 authors...
Abstract Background Although habituation is one of the most ancient and fundamental forms of learning, its regulators and its relevance for human disease are poorly understood. Methods We manipulated the orthologs of 286 genes implicated in intellectual disability (ID) with or without comorbid autism spectrum disorder (ASD) specifically in Drosophila neurons, and we tested these models in light-off jump habituation. We dissected neuronal substrates underlying the identified habituation deficits ...
1 CitationsSource
#1Mireia Coll-Tané (Radboud University Nijmegen)H-Index: 1
#2Alina Krebbers (Radboud University Nijmegen)H-Index: 1
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 5 authors...
ABSTRACT Intellectual disability (ID) and autism spectrum disorders (ASD) are frequently co-occurring neurodevelopmental disorders and affect 2-3% of the population. Rapid advances in exome and genome sequencing have increased the number of known implicated genes by threefold, to more than a thousand. The main challenges in the field are now to understand the various pathomechanisms associated with this bewildering number of genetic disorders, to identify new genes and to establish causality of ...
1 CitationsSource
#1Michaela Fenckova (Radboud University Nijmegen)H-Index: 10
#2Laura E.R. Blok (Radboud University Nijmegen)H-Index: 1
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 14 authors...
Abstract Background Although habituation is one of the most ancient and fundamental forms of learning, its regulators and relevance for human disease are poorly understood. Methods We manipulated the orthologs of 286 genes implicated in intellectual disability (ID) with or without comorbid autism spectrum disorder (ASD) specifically in Drosophila neurons, and tested these models in light-off jump habituation. We dissected neuronal substrates underlying the identified habituation deficits and int...
1 CitationsSource
#1Sarah Foriel (Radboud University Nijmegen)H-Index: 3
#2G. H. Renkema (Radboud University Nijmegen)H-Index: 1
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 8 authors...
Mitochondrial diseases are a group of rare life-threatening diseases often caused by defects in the oxidative phosphorylation system. No effective treatment is available for these disorders. Therapeutic development is hampered by the high heterogeneity in genetic, biochemical, and clinical spectra of mitochondrial diseases and by limited preclinical resources to screen and identify effective treatment candidates. Alternative models of the pathology are essential to better understand mitochondria...
1 CitationsSource
#1Human Riahi (Radboud University Nijmegen)H-Index: 2
#2Carlijn Brekelmans (Radboud University Nijmegen)H-Index: 1
Last.Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 11 authors...
Stress responses are crucial processes that require activation of genetic programs that protect from the stressor. Stress responses are also energy consuming and can thus be deleterious to the organism. The mechanisms coordinating energy consumption during stress response in multicellular organisms are not well understood. Here, we show that loss of the epigenetic regulator G9a in Drosophila causes a shift in the transcriptional and metabolic responses to oxidative stress (OS) that leads to decr...
3 CitationsSource
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