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Annette Schenck
Radboud University Nijmegen
GeneDrosophila melanogasterGeneticsIntellectual disabilityBiology
79Publications
31H-index
4,630Citations
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Publications 82
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Objective:Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with intellectual disability, and shared overlapping genetics...
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#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Marieke Klein (Radboud University Nijmegen)H-Index: 1
Last. Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 8 authors...
1 CitationsSource
#1Marieke KleinH-Index: 10
#2Euginia L. SinggihH-Index: 1
Last. Barbara FrankeH-Index: 76
view all 12 authors...
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#1Benjamin Harich (Radboud University Nijmegen)H-Index: 4
#2Monique van der Voet (Radboud University Nijmegen)H-Index: 12
Last. Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 7 authors...
Aim: Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable psychiatric disorder. The objective of this study was to define ADHD-associated candidate genes, and their associated molecular modules and biological themes, based on the analysis of rare genetic variants. Methods: We combined data from 11 published copy number variation (CNV) studies in 6176 individuals with ADHD and 25026 controls and prioritized genes by applying an integrative strategy based on criteria including rec...
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#1Michaela Fenckova (Radboud University Nijmegen)H-Index: 10
#2Laura E.R. Blok (Radboud University Nijmegen)H-Index: 1
Last. Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 14 authors...
Abstract Background Although habituation is one of the most ancient and fundamental forms of learning, its regulators and its relevance for human disease are poorly understood. Methods We manipulated the orthologs of 286 genes implicated in intellectual disability (ID) with or without comorbid autism spectrum disorder (ASD) specifically in Drosophila neurons, and we tested these models in light-off jump habituation. We dissected neuronal substrates underlying the identified habituation deficits ...
1 CitationsSource
#1Marieke Klein (Radboud University Nijmegen)H-Index: 10
#2Euginia L. Singgih (Radboud University Nijmegen)H-Index: 1
Last. Barbara Franke (Radboud University Nijmegen)H-Index: 76
view all 13 authors...
Objective: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with Intellectual Disability (ID), and shared overlapping genetics have been suggested. This study aimed to identify novel ADHD genes by investigating whether genes carrying rare mutations linked to ID contribute to ADHD risk through common genetic variants. Validation and characterization of candidates were performed using Drosophila melanogaster. Method: Comm...
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#1Mireia Coll-Tané (Radboud University Nijmegen)H-Index: 1
#2Alina Krebbers (Radboud University Nijmegen)H-Index: 1
Last. Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 5 authors...
ABSTRACT Intellectual disability (ID) and autism spectrum disorders (ASD) are frequently co-occurring neurodevelopmental disorders and affect 2-3% of the population. Rapid advances in exome and genome sequencing have increased the number of known implicated genes by threefold, to more than a thousand. The main challenges in the field are now to understand the various pathomechanisms associated with this bewildering number of genetic disorders, to identify new genes and to establish causality of ...
1 CitationsSource
#1Ilse Eidhof (Radboud University Nijmegen)H-Index: 3
#2B.P.C. van de Warrenburg (Radboud University Nijmegen)H-Index: 48
Last. Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 3 authors...
Background Genetic forms of ataxia are a heterogenous group of degenerative diseases of the cerebellum. Many causative genes have been identified. We aimed to systematically investigate these genes to better understand ataxia pathophysiology. Methods A manually curated catalogue of 71 genes involved in disorders with progressive ataxias as a major clinical feature was subjected to an integrated gene ontology, protein network and brain gene expression profiling analysis. Results We found that gen...
Source
#1Michaela Fenckova (Radboud University Nijmegen)H-Index: 10
#2Laura E.R. Blok (Radboud University Nijmegen)H-Index: 1
Last. Annette Schenck (Radboud University Nijmegen)H-Index: 31
view all 14 authors...
Abstract Background Although habituation is one of the most ancient and fundamental forms of learning, its regulators and relevance for human disease are poorly understood. Methods We manipulated the orthologs of 286 genes implicated in intellectual disability (ID) with or without comorbid autism spectrum disorder (ASD) specifically in Drosophila neurons, and tested these models in light-off jump habituation. We dissected neuronal substrates underlying the identified habituation deficits and int...
1 CitationsSource
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