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Yoosik Yoon
Chung-Ang University
AdipogenesisEndocrinologyWnt signaling pathwayBiochemistryBiology
85Publications
21H-index
1,096Citations
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Publications 84
Newest
#1Taehyun Bae (CAU: Chung-Ang University)H-Index: 1
#2Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
Last. Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 9 authors...
Abstract Ethnopharmacological relevance The dried root of Paeonia lactiflora Pall. (Radix Paeoniae) has been traditionally used to treat various inflammatory diseases in many Asian countries. Aim of the study Cancer cachexia is a catabolic syndrome driven by inflammation and characterised by a loss of skeletal muscle. This study aimed to assess the effects of an ethanolic extract of Radix Paeoniae (RP) on cancer cachexia and elucidate its mechanism of action. Material and methods The anti-cachex...
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#1Seong Yeon Choi (Kangwon National University)H-Index: 2
#2Birang Jeong (Kangwon National University)H-Index: 2
Last. Heejung Yang (Kangwon National University)H-Index: 11
view all 8 authors...
Source
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last. Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
AbstractAim: In this study, we report the anti-inflammatory activity of XAV939, a modulator of the Wnt/β-catenin pathway.Methods: WNT/β-catenin pathway and NF-κB signaling pathway were examined in LPS-stimulated human bronchial epithelial cells and effects of XAV939 on these pathways were analyzed. The effect of XAV939 was confirmed in human umbilical vein endothelial cells.Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-α, IL-1β, MCP-1, MMP-9, iNOS and COX-2 were sign...
2 CitationsSource
#1Birang Jeong (Kangwon National University)H-Index: 2
#2Jong Seong Roh (Dong-eui University)H-Index: 2
Last. Heejung Yang (Kangwon National University)H-Index: 11
view all 8 authors...
Background:DF formula is a herbal preparation comprised three medicinal herbs, namely, Ephedra intermedia, Rheum palmatum, and Lithospermum erythrorhizon, which is being used for the treatment of obesity and liver fibrosis in Korean local clinics. Objective: Since the abovementioned three herbs exist with different proportions in DF formula and their chemical markers have different physiochemical properties; it is quite challenging to develop an analytical methodology for the determination of th...
1 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last. Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
Abstract Ethnopharmacological relevance Gangjihwan (DF) which is composed of Ephedra intermedia , Lithospermum erythrorhizon , and Rheum palmatum has been used for the treatment of obesity in traditional medical clinics in Korea. Aim of the study This study was conducted to standardize DF and elucidate its mechanism of action for inhibiting fat accumulation in adipocytes and adipose tissues. Materials and methods The herbal ingredients of DF were extracted in water, 30% ethanol or 70% ethanol an...
3 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
Last. Dong-Jin OhH-Index: 1
view all 3 authors...
Fractalkine (CX3CL1) is a chemokine with a unique CX3C motif and is produced by endothelial cells stimulated with lipopolysaccharide (LPS), tumor necrosis factor (TNF)-α, interleukin (IL)-1, and interferon-γ. There have been several reports that the caspase/calpain system is activated in endotoxemia, which leads to cellular apoptosis and acute inflammatory processes. We aimed to determine the role of the caspase/calpain system in cell viability and regulation of fractalkine production in LPS-tre...
1 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last. Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 8 authors...
11 CitationsSource
#2Hye Rim LeeH-Index: 2
Last. Soon Shik ShinH-Index: 9
view all 8 authors...
Source
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last. Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 6 authors...
Abstract In this study, TNF-α was found to activate the WNT/β-catenin pathway in BEAS-2B human bronchial epithelial cells. Levels of phospho-LRP6, Dvl-2, and phospho-GSK-3β were elevated, while that of Axin was reduced by TNF-α treatment. Nuclear translocation of β-catenin and the reporter activity of a β-catenin-responsive promoter were increased by TNF-α treatment. Under the same experimental conditions, TNF-α activated the NF-κB signaling, which includes the phosphorylation and degradation of...
7 CitationsSource
#1Jaewoong Jang (CAU: Chung-Ang University)H-Index: 6
#2Yoonju Jung (CAU: Chung-Ang University)H-Index: 3
Last. Yoosik Yoon (CAU: Chung-Ang University)H-Index: 21
view all 5 authors...
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein endothelial cell (HUVEC)s were found to be prevented by Dickkopf-1 (DKK-1), a secreted Wnt antagonist, and LGK974, a small molecular inhibitor of the Wnt secretion. LPS-induced IκB degradation and NF-κB nuclear translocation as well as the expressions of pro-inflammatory genes including IL-6, IL-8, TNF- α, IL-1β, MCP-1, MMP-9, COX-2 and iNOS, were all suppressed by DKK-1 and LGK...
20 CitationsSource
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