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Amy Switzer
National Institutes of Health
ImmunologyAllergenEscherichia coliMedicineBiology
12Publications
3H-index
60Citations
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Publications 13
Newest
#1Josh McQuail (Imperial College London)
#2Amy Switzer (Imperial College London)H-Index: 3
Last. Ramesh Wigneshweraraj (Imperial College London)H-Index: 1
view all 4 authors...
Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has, amongst many, a key role in RNA metabolism. We reveal that Hfq is required by Escherichia coli to adapt to nitrogen (N) starvation. By using single molecule tracking photoactivated localisation microscopy imaging of individual Hfq molecules in live E. coli cells, we have uncovered an unusual behaviour of Hfq: We demonstrate that Hfq forms a distinct and reversible focus-like structure specifically in long-term N ...
Source
#1Mohamed H. Shamji (KI: Karolinska Institutet)H-Index: 24
#2Irene Thomsen (MHH: Hannover Medical School)H-Index: 2
Last. Claus Bachert (KI: Karolinska Institutet)H-Index: 87
view all 10 authors...
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by local production of polyclonal IgE idiotypes. Although tissue IgE concentrations can be in the range of several thousand kilounits per liter, the regulatory mechanisms by which IgE-mediated inflammation is controlled in patients with nasal polyps are not well understood. Objective We sought to determine whether locally induced IgG antibodies in patients with nasal polyps can inhibit an IgE-mediated proallergic...
Source
#1Josh McQuail (Imperial College London)
#2Amy Switzer (Imperial College London)H-Index: 3
Last. Ramesh Wigneshweraraj (Imperial College London)H-Index: 1
view all 3 authors...
Source
#1Mohamed H. Shamji (NIH: National Institutes of Health)H-Index: 24
#2Jasper Kappen (NIH: National Institutes of Health)H-Index: 3
Last. Stephen R. Durham (NIH: National Institutes of Health)H-Index: 96
view all 14 authors...
Background Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG4-associated inhibitory antibodies that prevent IgE-facilitated allergen binding to B cells. Objective We sought to determine whether SCIT induces nasal allergen-specific IgG4 antibodies with inhibitory activity that correlates closely with clinical response. Methods In a cross-sectional controlled study, nasal fluid and sera were collected during the grass pollen season from 10 SCIT-treated patien...
2 CitationsSource
#1Amy Switzer (Imperial College London)H-Index: 3
#2Daniel R. Brown (Imperial College London)H-Index: 7
Last. Sivaramesh Wigneshweraraj (Imperial College London)H-Index: 17
view all 3 authors...
Bacterial adaptive responses to biotic and abiotic stresses often involve large-scale reprogramming of the transcriptome. Since nitrogen is an essential component of the bacterial cell, the transcriptional basis of the adaptive response to nitrogen starvation has been well studied. The adaptive response to N starvation in Escherichia coli is primarily a ‘scavenging response’, which results in the transcription of genes required for the transport and catabolism of nitrogenous compounds. However, ...
2 CitationsSource
#1Amy Switzer (Imperial College London)H-Index: 3
#2Dimitrios Evangelopoulos (Francis Crick Institute)H-Index: 2
Last. Sivaramesh Wigneshweraraj (Imperial College London)H-Index: 17
view all 6 authors...
The initial adaptive transcriptional response to nitrogen (N) starvation in Escherichia coli involves large-scale alterations to the transcriptome mediated by the transcriptional activator, NtrC. One of these NtrC-activated genes is yeaG, which encodes a conserved bacterial kinase. Although it is known that YeaG is required for optimal survival under sustained N starvation, the molecular basis by which YeaG benefits N starved E. coli remains elusive. By combining transcriptomics with targeted me...
3 CitationsSource
#1Amy Switzer (Imperial College London)H-Index: 3
#2Dimitrios Evangelopoulos (Francis Crick Institute)H-Index: 2
Last. Sivaramesh Wigneshweraraj (Imperial College London)H-Index: 17
view all 6 authors...
The initial adaptive transcriptional response to nitrogen (N) starvation in Escherichia coli involves large-scale alterations to the transcriptome mediated by the transcription activator, NtrC. One of the NtrC-activated genes is yeaG, which encodes a conserved bacterial kinase. Although it is known that YeaG is required for optimal survival under sustained N starvation, the molecular basis by which YeaG benefits N starved E. coli remains elusive. By combining transcriptomics with targeted metabo...
Source
#1Paramita Sarkar (Imperial College London)H-Index: 1
#2Amy Switzer (Imperial College London)H-Index: 3
Last. Sivaramesh Wigneshweraraj (Imperial College London)H-Index: 17
view all 5 authors...
5 CitationsSource
#1Mohamed H. Shamji (NIH: National Institutes of Health)H-Index: 24
#2Jeff N. Temblay (Imperial College London)H-Index: 2
Last. Philip G. Ashton-Rickardt (Imperial College London)H-Index: 13
view all 11 authors...
Background The mechanisms that regulate maintenance of persistent T H 2 cells and potentiate allergic inflammation are not well understood. Objective The function of serine protease inhibitor 2A (Spi2A) was studied in mouse T H 2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 genes were studied in T H 2 cells from patients with grass pollen allergy. Methods Spi2A-deficient T H 2 cells were studied in in vitro culture or in vivo after challenge of Spi2A knockout mice with ova...
2 CitationsSource
#1Guy W. Scadding (NIH: National Institutes of Health)H-Index: 20
#2Aarif O. Eifan (NIH: National Institutes of Health)H-Index: 13
Last. Stephen R. Durham (NIH: National Institutes of Health)H-Index: 96
view all 12 authors...
Allergic rhinitis is common, troublesome, costly and associated with asthma 1, 2, 3. Specific allergen immunotherapy is an effective treatment 4, particularly for seasonal allergic rhinitis. Clinical trials of allergen immunotherapy face several challenges, including standardization of allergen exposure between individuals, seasons and locations. Additionally, the primary outcome – combined symptom and medication score – may be subject to poor compliance, the result being that large numbers of p...
28 CitationsSource
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