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Shawna E. Wicks
Pennington Biomedical Research Center
EndocrinologyInsulin resistanceInsulinSkeletal muscleBiology
13Publications
8H-index
193Citations
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Publications 13
Newest
#1Sujoy Ghosh (Pennington Biomedical Research Center)H-Index: 30
#2Shawna E. Wicks (Pennington Biomedical Research Center)H-Index: 8
Last. Robert C. Noland (Pennington Biomedical Research Center)H-Index: 19
view all 10 authors...
2 CitationsSource
#1Jaycob D. Warfel (LSU: Louisiana State University)H-Index: 4
#2Bolormaa Vandanmagsar (LSU: Louisiana State University)H-Index: 10
Last. Randall L. Mynatt (LSU: Louisiana State University)H-Index: 30
view all 6 authors...
Inhibiting fatty acid oxidation is one approach to lowering glucose levels in diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout mice (Cpt1bm-/-) comprise a model of impaired fat oxidation; and have decreased fat mass and enhanced glucose disposal and muscle oxidative capacity compared to controls. However, unfavorable effects occur relative to controls when Cpt1bm-/- mice are fed a 25% fat diet, including decreased activity and fat free mass and increased intramuscula...
4 CitationsSource
#1Bolormaa Vandanmagsar (LSU: Louisiana State University)H-Index: 10
#2Jaycob D. Warfel (LSU: Louisiana State University)H-Index: 4
Last. Randall L. Mynatt (LSU: Louisiana State University)H-Index: 30
view all 11 authors...
Summary Fatty acids are the primary fuel source for skeletal muscle during most of our daily activities, and impaired fatty acid oxidation (FAO) is associated with insulin resistance. We have developed a mouse model of impaired FAO by deleting carnitine palmitoyltransferase-1b specifically in skeletal muscle ( Cpt1b m−/− ). Cpt1b m−/− mice have increased glucose utilization and are resistant to diet-induced obesity. Here, we show that inhibition of mitochondrial FAO induces FGF21 expression spec...
30 CitationsSource
#1Shawna E. Wicks (Pennington Biomedical Research Center)H-Index: 8
#2Trang-Tiffany Nguyen (Pennington Biomedical Research Center)H-Index: 1
Last. Krisztian Stadler (Pennington Biomedical Research Center)H-Index: 21
view all 5 authors...
Abstract Obesity and metabolic syndrome are independent risk factors for chronic kidney disease, even without diabetes or hyperglycemia. Here, we compare two mouse models that are susceptible to diet-induced obesity: the relatively renal injury resistant C57BL/6J strain and the DBA2/J strain which is more sensitive to renal injury. Our studies focused on characterizing the effects of high fat diet feeding on renal oxidative stress, albuminuria, fibrosis and podocyte loss/insulin resistance. Whil...
16 CitationsSource
#1Sujoy Ghosh (Pennington Biomedical Research Center)H-Index: 30
#2Claudia Kruger (Pennington Biomedical Research Center)H-Index: 10
Last. Brenda K. Richards (Pennington Biomedical Research Center)H-Index: 7
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Background The liver is an important site of fat oxidation, which participates in the metabolic regulation of food intake. We showed previously that mice with genetically inactivated Acads, encoding short-chain acyl-CoA dehydrogenase (SCAD), shift food consumption away from fat and toward carbohydrate when tested in a macronutrient choice paradigm. This phenotypic eating behavior suggests a link between fat oxidation and nutrient choice which may involve an energy sensing mechanism. To identify ...
3 CitationsSource
#1Shawna E. Wicks (Pennington Biomedical Research Center)H-Index: 8
#2Bolormaa Vandanmagsar (Pennington Biomedical Research Center)H-Index: 10
Last. Randall L. Mynatt (Pennington Biomedical Research Center)H-Index: 30
view all 11 authors...
The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle insulin signaling. Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged and severe mitochondrial FAO inhibition results in increased carbohydrate utilization, along with reduced physical activity; increased circulating nonest...
42 CitationsSource
#1Carrie Waterman (RU: Rutgers University)H-Index: 8
#2Patricio Rojas-Silva (RU: Rutgers University)H-Index: 9
Last. Ilya Raskin (RU: Rutgers University)H-Index: 75
view all 11 authors...
Scope Moringa oleifera (moringa) is tropical plant traditionally used as an antidiabetic food. It produces structurally unique and chemically stable moringa isothiocyanates (MICs) that were evaluated for their therapeutic use in vivo.
40 CitationsSource
#1Kimberly R. Haynie (Pennington Biomedical Research Center)H-Index: 3
#2Bolormaa Vandanmagsar (Pennington Biomedical Research Center)H-Index: 10
Last. Randall L. Mynatt (Pennington Biomedical Research Center)H-Index: 30
view all 5 authors...
Recent reports suggest that short-term pharmacological carnitine palmitoyltransferase 1 (Cpt1) inhibition improves skeletal muscle glucose tolerance and insulin sensitivity. Although this appears promising for the treatment of diabetes, these Cpt1 inhibitors are not specific to skeletal muscle and target multiple Cpt1 isoforms. To assess the effects of inhibiting the Cpt1b isoform we generated mice with a heart- and skeletal muscle-specific deletion of the Cpt1b, Cpt1bHM−/−. These mice seem to d...
22 CitationsSource
#1Bolormaa Vandanmagsar (Pennington Biomedical Research Center)H-Index: 10
#2Kimberly R. Haynie (Pennington Biomedical Research Center)H-Index: 3
Last. Randall L. Mynatt (Pennington Biomedical Research Center)H-Index: 30
view all 8 authors...
Aims Bioactives of Artemisia dracunculus L. (termed PMI 5011) have been shown to improve insulin action by increasing insulin signalling in skeletal muscle. However, it has not known if PMI 5011’s effects are retained during an inflammatory condition. We examined the attenuation of insulin action and whether PMI 5011 enhances insulin signalling in the inflammatory environment with elevated cytokines.
10 CitationsSource
#1Shawna E. Wicks (Pennington Biomedical Research Center)H-Index: 8
#2Christopher M. Taylor (LSU: Louisiana State University)H-Index: 14
Last. David A. Welsh (LSU: Louisiana State University)H-Index: 21
view all 8 authors...
Abstract Objective The gut microbiome has been implicated in obesity and metabolic syndrome; however, most studies have focused on fecal or colonic samples. Several species of Artemisia have been reported to ameliorate insulin signaling both in vitro and in vivo. The aim of this study was to characterize the mucosal and luminal bacterial populations in the terminal ileum with or without supplementation with Artemisia extracts. Methods Following 4 wk of supplementation with different Artemisia ex...
6 CitationsSource
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