Yu-Show Fu
National Yang-Ming University
Publications 25
#1Pei-Jiun Tsai (NYMU: National Yang-Ming University)H-Index: 3
#2Pei-Jiun Tsai (NYMU: National Yang-Ming University)
Last.Yu-Show Fu (NYMU: National Yang-Ming University)H-Index: 13
view all 11 authors...
Background Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by the expansion of CAG repeats in ATXN1 gene resulting in an expansion of polyglutamine repeats in the ATXN1 protein. Unfortunately, there has yet been any effective treatment so far for SCA1. This study investigated the feasibility of transplanting human umbilical mesenchymal stem cells (HUMSCs) into transgenic SCA1 mice containing an expanded uninterrupted allele with 82 repeats in the A...
1 CitationsSource
#1Zikuan Leng (Xi'an Jiaotong University)
#2Dongming Sun (RU: Rutgers University)H-Index: 12
Last.Wise Young (RU: Rutgers University)H-Index: 47
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Multilineage-differentiating stress-enduring (Muse) cells are a population of pluripotent stage-specific embryonic antigen 3 (SSEA3)+ mesenchymal stem cells first described by Mari Dezawa in 2010. ...
#1Kuo-An ChuH-Index: 1
#2Shih-Yao WangH-Index: 1
Last.Yu-Show FuH-Index: 13
view all 10 authors...
Pulmonary fibrosis (PF) is a progressive and irreversible condition with various causes, and no effective treatment has been found to rescue fibrotic lungs. Successful recovery from PF requires inhibiting inflammation, promoting collagen degradation and stimulating alveolar regeneration. Human umbilical mesenchymal stem cells (HUMSCs) not only regulate immune responses but also synthesize and release hyaluronan to improve lung regeneration. This study investigated the feasibility of HUMSC engraf...
1 CitationsSource
#1Yu-Show Fu (NYMU: National Yang-Ming University)H-Index: 13
#2Chia-Hui Lu (NYMU: National Yang-Ming University)H-Index: 1
Last.Cheng-Fong Chen (NYMU: National Yang-Ming University)H-Index: 1
view all 8 authors...
1 CitationsSource
#1Pei-Yu Huang (NYMU: National Yang-Ming University)H-Index: 2
#2Yang-Hsin Shih (TMU: Taipei Medical University)H-Index: 26
Last.Yung-Yang LinH-Index: 25
view all 6 authors...
Abstract We evaluated the effects of intra-hippocampal transplantation of human umbilical mesenchymal stem cells (HUMSCs) on pilocarpine-treated rats. Sprague–Dawley rats were divided into the following three groups: (1) a normal group of rats receiving only PBS, (2) a status epilepticus (SE) group of rats with pilocarpine-induced SE and PBS injected into the hippocampi, and (3) a SE + HUMSC group of SE rats with HUMSC transplantation. Spontaneous recurrent motor seizures (SRMS) were monitored u...
11 CitationsSource
#1Yu-Pei Fan (NYMU: National Yang-Ming University)H-Index: 1
#2Ching-Chih HsiaH-Index: 1
Last.Yu-Show FuH-Index: 13
view all 12 authors...
A major complication in continuous, ambulatory peritoneal dialysis in patients with end-stage renal disease who are undergoing long-term peritoneal dialysis (PD) is peritoneal fibrosis, which can result in peritoneal structural changes and functional ultrafiltration failure. Human umbilical mesenchymal stem cells (HUMSCs) in Wharton's jelly possess stem cell properties and are easily obtained and processed. This study focuses on the effects of HUMSCs on peritoneal fibrosis in in vitro and in viv...
11 CitationsSource
#1Tsui-Ling Ko (NYMU: National Yang-Ming University)H-Index: 5
#2Yu-Yi FuH-Index: 2
Last.Yu-Show Fu (NYMU: National Yang-Ming University)H-Index: 13
view all 10 authors...
The success rate in previous attempts at transforming human umbilical mesenchymal stem cells (HUMSCs) isolated from Wharton's jelly of the umbilical cord into dopaminergic cells was a mere 12.7%. The present study was therefore initiated to establish a more effective procedure for better yield of dopaminergic cells in such transformation for more effective HUMSC-based therapy for parkinsonism. To examine, in vitro, the effects of enhanced Nurr1 expression in HUMSCs on their differentiation, cell...
7 CitationsSource
#1Han-Ying Wang (NTU: National Taiwan University)H-Index: 2
#2Zhao‐Chen Kuo (NTU: National Taiwan University)H-Index: 1
Last.Hsiu-Wen Yang (CSMU: Chung Shan Medical University)H-Index: 12
view all 6 authors...
Key points Noradrenaline (NA)-releasing neurons in the locus coeruleus (LC) provide NA to the forebrain and play important roles in regulating many brain functions. LC neurons are subject to tonic inhibition mediated by GABAB receptors (GABABRs) and that the extent of the effect varies with ambient GABA levels. GABABR-mediated tonic inhibition can effectively tune the spontaneous firing rate (SFR) of LC neurons; it is developmentally regulated and is responsible for maintaining a constant SFR of...
6 CitationsSource
After injury to the CNS, microglia are rapidly activated and concentrated and trigger inflammatory reaction at the sites of injury. Bone marrow mesenchymal stem cells (BMMSC) represent attractive cell sources for treating CNS injury. Although anti-inflammatory and paracrine effects of grafted BMMSC have been shown, direct modulation of BMMSC on microglia in situ remains unclear. The present work employs in vitro transwell assay to characterize the effects of BMMSC on LPS-stimulated microglia. BM...
10 CitationsSource
#1May-Jywan TsaiH-Index: 14
#2Pei-Jou HoH-Index: 1
Last.Henrich ChengH-Index: 29
view all 9 authors...
This work examines whether microglia-conditioned medium (MCM) is beneficial in stressed spinal cord cells or tissues. MCM was separated into two fractions by 50 kDa molecular cut-off centrifugation. MCM not only promoted survival of neuronal and oligodendroglial cells but effectively reduced LPS stimulation in spinal cord cultures. We further utilized the NYU weight-drop device to induce contusive spinal cord injury (SCI) in rats. Immediately after dropping the impactor from a height of 25 mm on...
1 CitationsSource