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Yu-Show Fu
National Yang-Ming University
23Publications
13H-index
2,354Citations
Publications 23
Newest
Published on Apr 18, 2019in Cell Transplantation 3.48
Zikuan Leng (Xi'an Jiaotong University), Dongming Sun12
Estimated H-index: 12
(RU: Rutgers University)
+ 9 AuthorsMari Dezawa40
Estimated H-index: 40
(Tohoku University)
Published on Jan 1, 2018in Cell Transplantation 3.48
Yu-Show Fu13
Estimated H-index: 13
(NYMU: National Yang-Ming University),
Chia-Hui Lu1
Estimated H-index: 1
(NYMU: National Yang-Ming University)
+ 5 AuthorsCheng-Fong Chen1
Estimated H-index: 1
(NYMU: National Yang-Ming University)
Published on May 1, 2016in Brain Behavior and Immunity 6.17
Pei-Yu Huang2
Estimated H-index: 2
(NYMU: National Yang-Ming University),
Yang-Hsin Shih25
Estimated H-index: 25
(TMU: Taipei Medical University)
+ 3 AuthorsYung-Yang Lin24
Estimated H-index: 24
Abstract We evaluated the effects of intra-hippocampal transplantation of human umbilical mesenchymal stem cells (HUMSCs) on pilocarpine-treated rats. Sprague–Dawley rats were divided into the following three groups: (1) a normal group of rats receiving only PBS, (2) a status epilepticus (SE) group of rats with pilocarpine-induced SE and PBS injected into the hippocampi, and (3) a SE + HUMSC group of SE rats with HUMSC transplantation. Spontaneous recurrent motor seizures (SRMS) were monitored u...
Published on Feb 1, 2016in Stem Cells Translational Medicine 5.96
Yu-Pei Fan1
Estimated H-index: 1
(NYMU: National Yang-Ming University),
Ching-Chih Hsia1
Estimated H-index: 1
+ 9 AuthorsYi-Chia Chiang1
Estimated H-index: 1
A major complication in continuous, ambulatory peritoneal dialysis in patients with end-stage renal disease who are undergoing long-term peritoneal dialysis (PD) is peritoneal fibrosis, which can result in peritoneal structural changes and functional ultrafiltration failure. Human umbilical mesenchymal stem cells (HUMSCs) in Wharton's jelly possess stem cell properties and are easily obtained and processed. This study focuses on the effects of HUMSCs on peritoneal fibrosis in in vitro and in viv...
Published on Nov 1, 2015in Cell Transplantation 3.48
Tsui-Ling Ko5
Estimated H-index: 5
(NYMU: National Yang-Ming University),
Yu-Yi Fu2
Estimated H-index: 2
+ 7 AuthorsYu-Show Fu13
Estimated H-index: 13
(NYMU: National Yang-Ming University)
The success rate in previous attempts at transforming human umbilical mesenchymal stem cells (HUMSCs) isolated from Wharton's jelly of the umbilical cord into dopaminergic cells was a mere 12.7%. The present study was therefore initiated to establish a more effective procedure for better yield of dopaminergic cells in such transformation for more effective HUMSC-based therapy for parkinsonism. To examine, in vitro, the effects of enhanced Nurr1 expression in HUMSCs on their differentiation, cell...
Published on Jan 1, 2015in The Journal of Physiology
Han‐Ying Wang2
Estimated H-index: 2
(NTU: National Taiwan University),
Zhao‐Chen Kuo1
Estimated H-index: 1
(NTU: National Taiwan University)
+ 3 AuthorsHsiu-Wen Yang12
Estimated H-index: 12
(CSMU: Chung Shan Medical University)
Key points Noradrenaline (NA)-releasing neurons in the locus coeruleus (LC) provide NA to the forebrain and play important roles in regulating many brain functions. LC neurons are subject to tonic inhibition mediated by GABAB receptors (GABABRs) and that the extent of the effect varies with ambient GABA levels. GABABR-mediated tonic inhibition can effectively tune the spontaneous firing rate (SFR) of LC neurons; it is developmentally regulated and is responsible for maintaining a constant SFR of...
Published on Jan 1, 2013in Oxidative Medicine and Cellular Longevity 4.87
Fan-Wei Tseng1
Estimated H-index: 1
,
May-Jywan Tsai15
Estimated H-index: 15
+ 3 AuthorsHenrich Cheng28
Estimated H-index: 28
After injury to the CNS, microglia are rapidly activated and concentrated and trigger inflammatory reaction at the sites of injury. Bone marrow mesenchymal stem cells (BMMSC) represent attractive cell sources for treating CNS injury. Although anti-inflammatory and paracrine effects of grafted BMMSC have been shown, direct modulation of BMMSC on microglia in situ remains unclear. The present work employs in vitro transwell assay to characterize the effects of BMMSC on LPS-stimulated microglia. BM...
Published on Jan 1, 2012in Advances in Bioscience and Biotechnology
May-Jywan Tsai15
Estimated H-index: 15
,
Pei-Jou Ho1
Estimated H-index: 1
+ 6 AuthorsHenrich Cheng1
Estimated H-index: 1
This work examines whether microglia-conditioned medium (MCM) is beneficial in stressed spinal cord cells or tissues. MCM was separated into two fractions by 50 kDa molecular cut-off centrifugation. MCM not only promoted survival of neuronal and oligodendroglial cells but effectively reduced LPS stimulation in spinal cord cultures. We further utilized the NYU weight-drop device to induce contusive spinal cord injury (SCI) in rats. Immediately after dropping the impactor from a height of 25 mm on...
Published on Jul 1, 2011in Stroke 6.05
Yu Ching Lin1
Estimated H-index: 1
(NYMU: National Yang-Ming University),
Tsui Ling Ko1
Estimated H-index: 1
+ 5 AuthorsYu-Show Fu13
Estimated H-index: 13
(NYMU: National Yang-Ming University)
Background and Purpose—Stroke is a cerebrovascular defect that leads to many adverse neurological complications. Current pharmacological treatments for stroke remain unclear in their effectiveness, whereas stem cell transplantation shows considerable promise. Previously, we have shown that human umbilical mesenchymal stem cells (HUMSCs) can differentiate into neurons in neuronal-conditioned medium. Here we evaluate the therapeutic potential of HUMSC transplantation for ischemic stroke in rats. M...
Published on Dec 1, 2010in Stem Cells and Development 3.15
Jui Yu Hsieh3
Estimated H-index: 3
(NYMU: National Yang-Ming University),
Yu-Show Fu13
Estimated H-index: 13
+ 2 AuthorsHsei-Wei Wang32
Estimated H-index: 32
(NYMU: National Yang-Ming University)
Mesenchymal stem cells (MSCs) found in bone marrow (BM)-MSCs are an attractive source for the regeneration of damaged tissues. Alternative postnatal, perinatal, and fetal sources of MSCs are also under intensive investigation. MSCs from the Wharton's jelly matrix of umbilical cord (WJ)-MSCs have higher pancreatic and endothelial differentiation potentials than BM-MSCs, but the underlying mechanisms are poorly understood. We compared the gene expression profiles, enriched canonical pathways, and ...
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