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Fermin Moreno
Instituto de Salud Carlos III
Publications 31
Published on Jun 10, 2019in Journal of Neurology, Neurosurgery, and Psychiatry 8.27
Stefano Gazzina9
Estimated H-index: 9
(University of Brescia),
Mario Grassi29
Estimated H-index: 29
(UNIPV: University of Pavia)
+ 30 AuthorsRaquel Sánchez-Valle33
Estimated H-index: 33
Objective Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods Two-hundred twent...
Published on Apr 1, 2019in NeuroImage 5.81
Enrico Premi17
Estimated H-index: 17
(University of Brescia),
Vince Daniel Calhoun87
Estimated H-index: 87
(UNM: University of New Mexico)
+ 130 AuthorsJohn VanSwieten68
Estimated H-index: 68
(EUR: Erasmus University Rotterdam)
Abstract Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 4...
Published on Nov 28, 2018in Frontiers in Aging Neuroscience 3.63
Gorka Fernández-Eulate , Ainhoa Alberro2
Estimated H-index: 2
+ 19 AuthorsNora Soberón3
Estimated H-index: 3
Many factors may converge in healthy ageing in the oldest old, but their association and predictive power on healthy o functionally impaired ageing has yet to be demonstrated. By detecting healthy ageing and in turn, poor ageing, we could take action to prevent chronic diseases associated with age. We conducted a pilot study comparing results of a set of markers (peripheral blood mononuclear cell telomere length or PBMC, circulating Aβ peptides, anti-Aβ antibodies, and ApoE status) previously as...
Published on Jun 1, 2018in Lancet Neurology 28.75
Cyril Pottier15
Estimated H-index: 15
(Mayo Clinic),
Xiaolai Zhou8
Estimated H-index: 8
(Mayo Clinic)
+ 130 AuthorsAdolfo López de Munain33
Estimated H-index: 33
(UPV/EHU: University of the Basque Country)
Summary Background Loss-of-function mutations in GRN cause frontotemporal lobar degeneration (FTLD). Patients with GRN mutations present with a uniform subtype of TAR DNA-binding protein 43 (TDP-43) pathology at autopsy (FTLD-TDP type A); however, age at onset and clinical presentation are variable, even within families. We aimed to identify potential genetic modifiers of disease onset and disease risk in GRN mutation carriers. Methods The study was done in three stages: a discovery stage, a rep...
Published on Jul 1, 2017in Alzheimers & Dementia 14.42
Katrina M. Dick7
Estimated H-index: 7
John VanSwieten68
Estimated H-index: 68
+ 42 AuthorsDaniela Galimberti54
Estimated H-index: 54
Published on Dec 1, 2016in Molecular Neurodegeneration 8.27
Carolina Alquézar7
Estimated H-index: 7
(CSIC: Spanish National Research Council),
Irene G. Salado4
Estimated H-index: 4
(CSIC: Spanish National Research Council)
+ 6 AuthorsÁngeles Martín-Requero14
Estimated H-index: 14
(CSIC: Spanish National Research Council)
Background Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the protein at Serine 409/410 residues. Casein kinase-1δ (CK-1δ) was reported to phosphorylate TDP-43 directly. Previous works from our laboratory described the presence of CDK6/pRb-dependent cell cycle alterations, and cytosolic accumulation of TDP-43 protein in lymphoblast from FTLD-...
Published on Jul 1, 2016in Journal of Psychiatry & Neuroscience 4.90
Carolina Alquézar7
Estimated H-index: 7
Ana de la Encarnación5
Estimated H-index: 5
+ 2 AuthorsÁngeles Martín-Requero14
Estimated H-index: 14
Loss-of-function progranulin gene (GRN) mutations have been identified as the major cause of frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein 43 (TDP-43) pathology (frontotemporal lobar degeneration [FTLD]-TDP); however, little is known about the association between progranulin (PGRN) deficiency and neuronal loss in individuals with FTLD-TDP. Previously we reported enhanced proliferative activity associated with the activation of WNT5A/CDK6/pRb signalling in ...
Published on Feb 1, 2016in Neurobiology of Aging 4.40
Oriol Dols-Icardo10
Estimated H-index: 10
(Autonomous University of Barcelona),
Oriol Iborra1
Estimated H-index: 1
(Autonomous University of Barcelona)
+ 25 AuthorsAlberto Lleó31
Estimated H-index: 31
(Autonomous University of Barcelona)
Abstract The tubulin alpha 4a ( TUBA4A ) gene has been recently associated with amyotrophic lateral sclerosis. Interestingly, some of the mutation carriers were also diagnosed with frontotemporal degeneration (FTD) or mild cognitive impairment. With the aim to investigate the role of TUBA4A in FTD, we screened TUBA4A in a series of 814 FTD patients from Spain. Our data did not disclose any nonsense or missense variant in the cohort, thus suggesting that TUBA4A mutations are not associated with F...