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Xihong Lin
Harvard University
311Publications
53H-index
14.1kCitations
Publications 311
Newest
AbstractStudying the effects of groups of single nucleotide polymorphisms (SNPs), as in a gene, genetic pathway, or network, can provide novel insight into complex diseases like breast cancer, unco...
#1Zhonghua Liu (HKU: University of Hong Kong)H-Index: 3
#2Xihong Lin (Harvard University)H-Index: 53
ABSTRACTJoint analysis of multiple phenotypes can increase statistical power in genetic association studies. Principal component analysis, as a popular dimension reduction method, especially when t...
#1Tianle Hu (Eli Lilly and Company)H-Index: 2
#2Bin Nan (UCI: University of California, Irvine)
Last.Xihong Lin (Harvard University)H-Index: 53
view all 3 authors...
Cross-ratio is an important local measure of the strength of dependence among correlated failure times. If a covariate is available, it may be of scientific interest to understand how the cross-ratio varies with the covariate as well as time components. Motivated by the Tremin study, where the dependence between age at a marker event reflecting early lengthening of menstrual cycles and age at menopause may be affected by age at menarche, we propose a proportional cross-ratio model through a base...
#1Miao Xu (Harvard University)
#2Youyuan Yao (SYSU: Sun Yat-sen University)H-Index: 1
Last.Tong Xiang (SYSU: Sun Yat-sen University)H-Index: 2
view all 31 authors...
Epstein–Barr virus (EBV) infection is ubiquitous worldwide and is associated with multiple cancers, including nasopharyngeal carcinoma (NPC). The importance of EBV viral genomic variation in NPC development and its striking epidemic in southern China has been poorly explored. Through large-scale genome sequencing of 270 EBV isolates and two-stage association study of EBV isolates from China, we identify two non-synonymous EBV variants within BALF2 that are strongly associated with the risk of NP...
#1Brian E. Cade (Brigham and Women's Hospital)H-Index: 19
#2Jiwon Lee (Brigham and Women's Hospital)
Last.Jacqueline M Lane (Brigham and Women's Hospital)
view all 38 authors...
Sleep-disordered breathing (SDB) is a common disorder associated with significant morbidity. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program we report the first whole-genome sequence analysis of SDB. We identified 4 rare gene-based associations with SDB traits in 7,988 individuals of diverse ancestry and 4 replicated common variant associations with inclusion of additional samples (n=13,257). We identified a multi-ethnic set-based rare-variant association (p = 3.48 x 10-8) ...
#1Cheng Peng (Brigham and Women's Hospital)H-Index: 3
#2Andres Cardenas (Harvard University)H-Index: 17
Last.Juan C. Celedón (University of Pittsburgh)H-Index: 57
view all 14 authors...
Background Epigenetic clocks have been suggested to capture one feature of the complexity between aging and the epigenome. However, little is known about the epigenetic clock in childhood allergy and asthma. Objective We sought to examine associations of DNA methylation age (DNAmAge) and epigenetic age acceleration with childhood allergy and asthma. Methods We calculated DNAmAge and age acceleration at birth, early childhood, and midchildhood based on the IlluminaHumanMethylation450BeadChip in P...
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