Max Lam
Broad Institute
Publications 62
Abstract Background Converging evidence has indicated that deficits in social cognition may manifest as poor functioning; therefore, social cognition has emerged as an important research area and treatment target. However, few studies have examined the psychometrics of multiple social cognition measures in an Asian population. This study aims to evaluate the psychometrics of measures indexing the four core social cognition domains. Methods Schizophrenia outpatients (n = 116) and healthy controls...
#1Gail Davies (Edin.: University of Edinburgh)H-Index: 52
#2Max LamH-Index: 10
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 222 authors...
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
1 CitationsSource
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have...
2 CitationsSource
#1Max LamH-Index: 10
#2Chia-Yen ChenH-Index: 15
Last.Hailiang HuangH-Index: 31
view all 14 authors...
#1Keane LimH-Index: 2
#2Max LamH-Index: 10
Last.James LeeH-Index: 95
view all 4 authors...
#1Todd LenczH-Index: 68
#2Jin YuH-Index: 16
Last.Itsik Pe'erH-Index: 40
view all 6 authors...
#1Max LamH-Index: 10
#2Swapnil Awasthi (Charité)H-Index: 6
Last.Stephan Ripke (Charité)H-Index: 74
view all 22 authors...
3 CitationsSource
#1Max Lam (Broad Institute)H-Index: 10
#2W. David Hill (Edin.: University of Edinburgh)H-Index: 18
Last.Todd Lencz (Hofstra University)H-Index: 6
view all 68 authors...
Liability to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported between schizophrenia and educational attainment, despite the strong positive genetic correlation between cognitive ability and educational attainment. Here we leverage published GWAS in cognitive ability, education, and schizophrenia to parse biological mechanisms underlying these results...
2 CitationsSource