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Kazutaka Aoki
Yokohama City University
51Publications
15H-index
746Citations
Publications 51
Newest
#1Sho Kinguchi (YCU: Yokohama City University)H-Index: 4
#2Hiromichi Wakui (YCU: Yokohama City University)H-Index: 17
Last.Kouichi Tamura (YCU: Yokohama City University)H-Index: 27
view all 29 authors...
The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) and albuminuria. We conducted a prospective, multicenter, single-arm study. Eighty-six patients with T2DM, HbA1c 7.0–10.0%, estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m2, and urine albumin-to-creatinine ratio (UACR) ≥ 30 mg/g creatinine (gCr) were enrolled, and 85 of these patients ...
1 CitationsSource
#1Kazutaka Aoki (YCU: Yokohama City University)H-Index: 15
#2Haruhiro SatoH-Index: 10
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 3 authors...
2 CitationsSource
#1Masayo Kimura (YCU: Yokohama City University)H-Index: 2
#2Yoshinobu Kondo (YCU: Yokohama City University)H-Index: 6
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 8 authors...
Background: Low-carbohydrate diets have been shown to effectively improve the metabolic status of patients with type 2 diabetes mellitus. However, patients may find it challenging to maintain a strict low-carbohydrate diet. The objective of this study was to determine if a one-meal, low-carbohydrate diet is as effective in improving metabolic status as a conventional, energy-restricted diet among patients with type 2 diabetes mellitus. Methods: In this 12-week randomized controlled study, the pr...
3 CitationsSource
#1Kazutaka Aoki (YCU: Yokohama City University)H-Index: 15
#2Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
Abstract Type 2 diabetes is a metabolic disorder that is characterized by an impaired capacity to secrete insulin, insulin resistance, or both. Dehydroepiandrosterone (DHEA), a steroid hormone produced by the adrenal cortex, has been reported to have beneficial effects on diabetes mellitus and obesity in animal models. DHEA and DHEA-sulfate (DHEA-S) have been reported to increase not only insulin secretion of the pancreas but also insulin sensitivity of the liver, adipose tissue, and muscle. We ...
Source
#2Kiyoshi YoshimuraH-Index: 16
Last.Hiroaki NaganoH-Index: 52
view all 22 authors...
Source
#1Kazutaka AokiH-Index: 15
#2Mieko NagakuraH-Index: 2
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 11 authors...
Background: Patients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose dose combination (LDC) regimen to an FDC regimen at equivalent dosage on glycemic control has not been evaluated fully. Therefore, we investigated the effect of switching from LDC to FDC at equivalent dosage for 6 months on glycemic control in Japane...
2 CitationsSource
#1Eriko Shibata (YCU: Yokohama City University)H-Index: 1
#2Kazutaka Aoki (YCU: Yokohama City University)H-Index: 15
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 5 authors...
ABSTRACTObjective: We compared the efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal. Primary efficacy parameter is the area under the curve (AUC) for postprandial plasma glucose.Methods: Miglitol was administered according to three different intake schedules in each subject: intake schedule A, no miglitol; intake schedule B, administration of miglitol (50 mg) just before breakfast; intake schedule C, dissolving miglitol (50 m...
2 CitationsSource
#1Kazutaka Aoki (YCU: Yokohama City University)H-Index: 15
#2Kazuki Tajima (YCU: Yokohama City University)H-Index: 12
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 4 authors...
Abstract We have previously reported that dehydroepiandrosterone (DHEA) suppresses the activity and mRNA expression of the hepatic gluconeogenic enzyme glucose-6-phosphatase (G6Pase), and hepatic glucose production in db/db mice. Tyrosine phosphorylation levels of Insulin receptor substrate (IRS)1 and IRS2 reportedly differ between the liver and muscle tissue and the effect of DHEA on insulin signaling has not been elucidated. Therefore, we examined DHEA’s effect on the liver and muscle tissue o...
5 CitationsSource
#1Hiroshi Kamiyama (YCU: Yokohama City University)H-Index: 6
#2Kazutaka Aoki (YCU: Yokohama City University)H-Index: 15
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 7 authors...
Objective Switching from sulfonylureas to repaglinide in patients with type 2 diabetes improves glycemic control; however, the optimal dosage has not been fully evaluated. We designed to show that repaglinide was equivalent to sulfonylurea in Japanese patients with type 2 diabetes. We herein evaluated whether we could switch from sulfonylureas to repaglinide twice or thrice daily in Japanese adult patients who had been treated with anti-diabetic drugs, including sulfonylureas, and whose conditio...
2 CitationsSource
#1Kazunari Kamiko (YCU: Yokohama City University)H-Index: 4
#2Kazutaka Aoki (YCU: Yokohama City University)H-Index: 15
Last.Yasuo Terauchi (YCU: Yokohama City University)H-Index: 58
view all 5 authors...
Background: A fast eating speed is reportedly associated with obesity, fatty liver, and metabolic syndrome. As a comparison of postprandial glucose levels after eating quickly or slowly has not been previously reported for Japanese patients with type 2 diabetes, we evaluated the impact of the fast or slow ingestion of an enteral formula (liquid meal) on glucose metabolism. Methods: Ten Japanese patients with type 2 diabetes who had been hospitalized at our hospital were enrolled. All the subject...
1 CitationsSource
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