Sarah Bühler
University of Tübingen
9Publications
6H-index
134Citations
Publications 9
Newest
Published on Oct 1, 2015in International Journal of Surgery
Carl Christoph Schneider2
Estimated H-index: 2
(University of Tübingen),
Rami Archid3
Estimated H-index: 3
(University of Tübingen)
+ 9 AuthorsAlfred Königsrainer41
Estimated H-index: 41
(University of Tübingen)
Abstract Background and Objectives It can be assumed that PGK1 is involved in metastatic spread of gastric carcinomas. Furthermore PGK1 has a proven influence on the characteristics of tumor stem cells. The presence of malignant stem cells, regarding treatment resistance and recurrence, is of considerable importance. We hypothesized that inhibition of PGK1 makes these cells more sensitive to chemotherapeutic agents and therefore mediates an overcome of the existing therapy resistance. Methods Al...
3 Citations Source Cite
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 1 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Jul 1, 2013in International Journal of Oncology 3.33
Sufian S. Ahmad2
Estimated H-index: 2
(University of Tübingen),
Jörg Glatzle19
Estimated H-index: 19
(University of Tübingen)
+ 9 AuthorsHinnak Northoff38
Estimated H-index: 38
(University of Tübingen)
Oxidative stress due to intratumoral hypoxia in solid cancer has been shown to be associated with increased mortality. Phosphoglycerate kinase 1 (PGK1) is an enzyme of the glycolytic pathway, which is regulated by hypoxia-induc- ible factor-1α (HIF-1α) and has been described for its role in tumor progression and metastasis in several malignancies. We investigated whether the expression of PGK1 varies between metastatic and non-metastatic colon cancer. We compared PGK1 expression in colon cancer ...
26 Citations Source Cite
Published on Apr 1, 2013in Langenbeck's Archives of Surgery 2.30
Derek Zieker18
Estimated H-index: 18
(University of Tübingen),
Sarah Bühler6
Estimated H-index: 6
(University of Tübingen)
+ 8 AuthorsAlfred Königsrainer41
Estimated H-index: 41
(University of Tübingen)
Purpose Metastases are a frequent finding in gastric cancer and are associated with poor prognosis. A recently discovered link between metabolic changes, differentiation, and therapy resistance due to tumor stem cells could depict a novel approach in cancer research and therapy. Phosphoglycerate kinase 1 (PGK1) is a metabolic enzyme and is known to be involved in enabling gastric cancer cells to be invasive and to disseminate. In this study, we investigated if PGK1 is a promising candidate in in...
15 Citations Source Cite
Published on Jan 1, 2012in Cellular Physiology and Biochemistry 5.50
Carl-Christoph Schneider1
Estimated H-index: 1
,
Atesch Ateschrang10
Estimated H-index: 10
+ 6 AuthorsDerek Zieker18
Estimated H-index: 18
Background/Aims: Wounds, especially non-healing wounds are characterized by elevated tissue lactate concentrations. Lactate is known for being able to stimulate collagen synthesis and vessel growth. Lately it has been shown that lactate, in vivo, plays an important role in homing of stem cells. With this work we aimed to show the influence of lactate on the gene expressionprofile of human mesenchymal stem cells (hMSC). Materials and Methods: hMSCs were obtained from bone marrow and characterized...
2 Citations Source Cite
Published on Jan 1, 2012in Exercise Immunology Review 7.11
Ingmar Königsrainer18
Estimated H-index: 18
,
Markus W. Löffler8
Estimated H-index: 8
+ 9 AuthorsSilvio Nadalin36
Estimated H-index: 36
Subsequent to prolonged exhausting exercise a transient immunosuppression is often observed in athletes. This so-called “open window” results in a reduced resistance of the athletes to viral and bacterial infections after an exhaustive exer cise bout. Concerning the effect of bacterial endotoxin contact after exhausting exercise in transplant recipients, who are innately immunosuppressed by their medication, no data exists at present. After performing 81 km cycling, including ascending more than...
3 Citations
Published on Jan 1, 2010in Exercise Immunology Review 7.11
Ingmar Königsrainer18
Estimated H-index: 18
,
Derek Zieker18
Estimated H-index: 18
(University of Tübingen)
+ 7 AuthorsAlfred Königsrainer41
Estimated H-index: 41
Prolonged exhaustive exercise has a great impact on the immune system of athletes and leads to a transient weakening of the immune system. A host of studies has documented changes of immune parameters in peripheral blood following exercise. Concerning the effect of exhaustive exercise in transplant recipients there is little knowledge at present. We analysed peripheral blood in healthy athletes and transplant recipients who participated in the „Euregio cycling tour 2009“ before and immediately a...
8 Citations
Published on Jan 1, 2010in Cellular Physiology and Biochemistry 5.50
Derek Zieker18
Estimated H-index: 18
(University of Tübingen),
Ingmar Königsrainer18
Estimated H-index: 18
(University of Tübingen)
+ 13 AuthorsHinnak Northoff38
Estimated H-index: 38
(University of Tübingen)
Background/Aims: Tumor dissemination is frequent in gastric cancer and implies a poor prognosis. Cure is only achievable provided an accurate staging is performed at primary diagnosis. In previous studies we were able to show a relevant impact of increased phosphoglycerate kinase 1 expression (PGK1; a glycolytic enzyme) on invasive properties of gastric cancer in-vivo and in-vitro. Thus the aim of the present study was to evaluate the effect of enhanced PGK1 expression in gastric cancer employin...
28 Citations Source Cite
Published on Jan 1, 2010in International Journal of Cancer 7.36
Derek Zieker18
Estimated H-index: 18
(University of Tübingen),
Ingmar Königsrainer18
Estimated H-index: 18
(University of Tübingen)
+ 11 AuthorsJochen Gaedcke23
Estimated H-index: 23
(University of Göttingen)
Peritoneal carcinomatosis is a frequent finding in gastric cancer associated with a poor prognosis. The features that enable gastric tumors to disseminate are poorly understood until now. Previously, we showed elevated mRNA levels of phosphoglycerate kinase 1 (PGK1), an adenosine triphosphate-generating enzyme in the glycolytic pathway, the chemokine receptor 4 (CXCR4), the corresponding chemokine ligand 12 (CXCL12) and β-catenin in specimens from gastric cancer patients with peritoneal carcinom...
41 Citations Source Cite
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