Tamara Grodzicky
Université de Montréal
Publications 20
#1Marvin J. Fritzler (U of C: University of Calgary)H-Index: 57
#2Marie Hudson (McGill University)H-Index: 39
Last.M. J. FritzlerH-Index: 7
view all 32 authors...
Abstract We studied the clinical correlations and epitopes of autoantibodies directed to a novel autoantigen, Bicaudal D (BICD2), in systemic sclerosis (SSc) and reviewed its relationship to centromere protein A (CENP-A). 451 SSc sera were tested for anti-BICD2 using a paramagnetic bead immunoassay and then univariate and multivariate logistic regression was used to study the association between anti-BICD2 and demographic and clinical parameters as well as other SSc-related autoantibodies. Epito...
4 CitationsSource
#1Murray Baron (McGill University)H-Index: 44
#2Janet E. Pope (UWO: University of Western Ontario)H-Index: 58
Last.Marie Hudson (McGill University)H-Index: 39
view all 24 authors...
13 CitationsSource
#1Mélanie Racine (UWO: University of Western Ontario)H-Index: 12
#2Marie Hudson (McGill University)H-Index: 39
Last.Maggie LarchéH-Index: 19
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Abstract Context Pain and itch are common symptoms reported by patients with systemic sclerosis (SSc; scleroderma), which can markedly diminish function and health-related quality of life (HRQL). Objectives The aim of this exploratory study was to examine the impact that pain, itch, and the interaction of both have on function (depressive symptoms, overall disability, fatigue, sleep disturbance) and HRQL in patients with SSc. Methods A total of 964 patients from the Canadian Scleroderma Reserch ...
11 CitationsSource
#1Hebah Alhajeri (JGH: Jewish General Hospital)H-Index: 1
#2Marie Hudson (JGH: Jewish General Hospital)H-Index: 24
Last.Murray Baron (JGH: Jewish General Hospital)H-Index: 44
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Objective The goal of this study was to determine the sensitivity of the new 2013 classification criteria for systemic sclerosis (SSc; scleroderma) in an independent cohort of SSc subjects and to assess the contribution of individual items of the criteria to the overall sensitivity. Methods SSc subjects from the Canadian Scleroderma Research Group cohort were assessed. Sensitivity was determined in several subgroups of patients. In patients without the criterion of skin thickening proximal to th...
40 CitationsSource
#1Yves TroyanovH-Index: 7
#2Ira N. TargoffH-Index: 36
Last.Jean-Luc SenécalH-Index: 29
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Dermatomyositis (DM) is a major clinical subset of autoimmune myositis (AIM). The characteristic DM rash (Gottron papules, heliotrope rash) and perifascicular atrophy at skeletal muscle biopsy are regarded as specific features for this diagnosis. However, new concepts are challenging the current definition of DM. A modified Bohan and Peter classification of AIM was proposed in which the core concept was the inclusion of the diagnostic significance of overlap connective tissue disease features. I...
35 CitationsSource
#1L Miller (UdeM: Université de Montréal)H-Index: 1
#2S Chartrand (UdeM: Université de Montréal)H-Index: 2
Last.Tamara Grodzicky (UdeM: Université de Montréal)H-Index: 12
view all 10 authors...
Objectives: Pulmonary hypertension (PH) causes mortality in systemic sclerosis (SSc). Pulmonary arterial hypertension (PAH) and left heart disease (LHD) are frequent causes of PH. Therefore, we studied PAH and LHD in early PH.Method: A total of 432 French Canadian SSc patients were studied retrospectively. All underwent screening for PH. We analysed clinical, serological, and radiographic data from 26 patients with early PH diagnosed by right heart catheterization (RHC). SSc patients with (n = 2...
7 CitationsSource
#1Stéphane Chabaud (Laval University)H-Index: 11
#2Marie-Pier Corriveau (Laval University)H-Index: 2
Last.Véronique Moulin (Laval University)H-Index: 19
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Our hypothesis is that the development of lesional areas of skin in patients with systemic sclerosis (SSc) originates from the selection of profibrotic cell subpopulations within their non-lesional skin areas, due to their greater resistance to apoptosis. Sensitivity to apoptosis of early-stage or late-stage SSc fibroblasts as well as of healthy cells was compared using extrinsic or intrinsic apoptotic pathway-inducers. Subpopulations of non-lesional SSc cells and healthy cells obtained after re...
11 CitationsSource
#2Ines BoufaiedH-Index: 1
Last.Véronique Moulin (Laval University)H-Index: 19
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We set out to examine the pathophysiological mechanisms of fibrosis in diffuse systemic sclerosis (SSc) using a tissue engineering approach. Skin fibroblasts were isolated from lesional skin of SSc patients with a disease duration of less than 1 year (early-stage SSc) or more than 10 years (late-stage SSc). Fibroblasts were also isolated from non-lesional skin and compared with normal fibroblasts isolated from healthy adults. Cells were cultured using a tissue engineering method to reconstruct a...
25 CitationsSource
#1Martial Koenig (UdeM: Université de Montréal)H-Index: 9
#2Marvin J. Fritzler (U of C: University of Calgary)H-Index: 57
Last.Jean-Luc Senécal (UdeM: Université de Montréal)H-Index: 29
view all 10 authors...
Objective To identify in patients with Raynaud's phenomenon (RP) independent markers that predict progression to definite systemic sclerosis (SSc) and to determine in patients with progression to SSc the type and sequence of microvascular damage and its relationship to SSc-specific autoantibodies. Methods Consecutive patients referred for evaluation of RP who had no definite connective tissue disease were evaluated for microvascular damage by nailfold capillary microscopy (NCM) and for anticentr...
338 CitationsSource
#2Ines BoufaiedH-Index: 1
Last.Véronique MoulinH-Index: 19
view all 7 authors...