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Takaaki Shimohata
University of Tokushima
EndocrinologyVibrio parahaemolyticusBiochemistryBiologyMicrobiology
37Publications
9H-index
273Citations
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Publications 35
Newest
#1Anh Quoc NguyenH-Index: 2
#1Anh Quoc Nguyen (NIN: National Institute of Nutrition, Hyderabad)
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 9 authors...
Vibrio parahaemolyticus is a Gram-negative halophilic pathogen that frequently causes acute gastroenteritis and occasional wound infection. V. parahaemolyticus contains several virulence factors, including type III secretion systems (T3SSs) and thermostable direct hemolysin (TDH). In particular, T3SS1 is a potent cytotoxic inducer, and T3SS2 is essential for causing acute gastroenteritis. Although much is known about manipulation of host signaling transductions by the V. parahaemolyticus effecto...
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#1Takashi Uebanso (University of Tokushima)H-Index: 11
#2Ayumi Yoshimoto (University of Tokushima)H-Index: 3
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 8 authors...
Microbes in the human gut play a role in the production of bioactive compounds, including some vitamins. Although several studies attempted to identify definitive markers for certain vitamin deficiencies, the role of gut microbiota in these deficiencies is unclear. To investigate the role of gut microbiota in deficiencies of four vitamins, B2, B6, folate, and B12, we conducted a comprehensive analysis of metabolites in mice treated and untreated with antibiotics. We identified glycolate (GA) as ...
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#1Maria Ulfa (University of Tokushima)
#2Momoyo Azuma (University of Tokushima)H-Index: 13
Last. Takahiro Emoto (University of Tokushima)H-Index: 6
view all 13 authors...
The prevalence of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli is increasing rapidly and spreading worldwide, particularly in Asia, compared to other regions. In the last ten years, in our hospital, in particular, there has been a < 30% increase. To prevent the spread of ESBL in hospitals and the community, the ultraviolet (UV) A-light-emitting diode (LED) irradiation device was used to inactivate ESBL-E. coli in human livestock and the environment. ESBL-E. coli and E. coli ba...
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#1Hiromichi Yumoto (University of Tokushima)H-Index: 24
#2Takashi Uebanso (University of Tokushima)H-Index: 11
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 4 authors...
Purpose of Review The oral cavity is one of the main gateways to the whole body and leads to the gastrointestinal tract. Both oral cavity and gastrointestinal tract have complex ecosystems of microorganisms called microbiota. Recent studies have shown that altered local microbiome in human, such as gut microflora, is associated with various systemic diseases. This review focuses on the association between the microbiota at local sites, such as gut and oral cavity, and the systemic diseases, espe...
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#1Takaaki Shimohata (University of Tokushima)H-Index: 9
#2Kazuaki Mawatari (University of Tokushima)H-Index: 16
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 25 authors...
Chronic care patients undergoing hemodialysis for treatment of end-stage renal failure experience higher rates of bloodstream-associated infection due to the patients' compromised immune system and management of the bloodstream through catheters. Staphylococcus species are a common cause of hemodialysis catheter-related bloodstream infections. We investigated environmental bacterial contamination of dialysis wards and contamination of hemodialysis devices to determine the source of bacteria for ...
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#1Risa Nishisaka-Nonaka (University of Tokushima)H-Index: 1
#2Kazuaki Mawatari (University of Tokushima)H-Index: 16
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 17 authors...
Abstract Influenza A viruses (IAVs) pose a serious global threat to humans and their livestock, especially poultry and pigs. This study aimed to investigate how to inactivate IAVs by using different ultraviolet-light-emitting diodes (UV-LEDs). We developed sterilization equipment with light-emitting diodes (LEDs) those peak wavelengths were 365 nm (UVA-LED), 310 nm (UVB-LED), and 280 nm (UVC-LED). These UV-LED irradiations decreased dose fluence-dependent plaque-forming units of IAV H1N1 subtype...
1 CitationsSource
#1Aya Tentaku (University of Tokushima)H-Index: 2
#2Takaaki Shimohata (University of Tokushima)H-Index: 9
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 12 authors...
Campylobacter jejuni is a major cause of bacterial foodborne illness in humans worldwide. Bacterial entry into a host eukaryotic cell involves the initial steps of adherence and invasion, which generally activate several cell-signaling pathways that induce the activation of innate defense systems, which leads to the release of proinflammatory cytokines and induction of apoptosis. Recent studies have reported that the unfolded protein response (UPR), a system to clear unfolded proteins from the e...
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#1Akari Tsunedomi (University of Tokushima)
#2Katsuyuki Miyawaki (University of Tokushima)H-Index: 21
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 11 authors...
The number of plant factories in which crops are cultivated in an artificial environment has been increasing every year. In cultivation techniques involving hydroponics, plants are supplied with a circulating nutrient solution, which can become contaminated by pathogens that can propagate and spread throughout plant factories. Therefore, strategies to disinfect hydroponic nutrient solutions are needed. In this study, we developed a new disinfection device equipped with an ultraviolet A (UVA) lig...
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#1Ayumi Yoshimoto (University of Tokushima)H-Index: 3
#2Takashi Uebanso (University of Tokushima)H-Index: 11
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 6 authors...
Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns’ health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose...
3 CitationsSource
#1Sho Hatayama (University of Tokushima)H-Index: 2
#2Takaaki Shimohata (University of Tokushima)H-Index: 9
Last. Akira Takahashi (University of Tokushima)H-Index: 33
view all 13 authors...
Campylobacter jejuni invasion is closely related to C. jejuni pathogenicity. The intestinal epithelium contains polarized epithelial cells that form tight junctions (TJs) to provide a physical barrier against bacterial invasion. Previous studies indicated that C. jejuni invasion of non-polarized cells involves several cellular features, including lipid rafts. However, the dynamics of C. jejuni invasion of polarized epithelial cells are not fully understood. Here we investigated the interaction b...
3 CitationsSource
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