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Lynda J. Brown
University of Southampton
OligonucleotideOrganic chemistryChemistrySinglet statePhotochemistry
65Publications
18H-index
1,180Citations
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Publications 58
Newest
#1Bogdan A. Rodin (NSU: Novosibirsk State University)H-Index: 2
#2Christian Bengs (University of Southampton)H-Index: 7
Last. Malcolm H. Levitt (University of Southampton)H-Index: 67
view all 9 authors...
Algorithmic cooling methods manipulate an open quantum system in order to lower its temperature below that of the environment. We achieve significant cooling of an ensemble of nuclear spin-pair systems by exploiting the long-lived nuclear singlet state, which is an antisymmetric quantum superposition of the "up" and "down" Zeeman states. The effect is demonstrated by nuclear magnetic resonance experiments on a molecular system containing a coupled pair of near-equivalent (13)C nuclei. The popula...
Source
#1Bogdan A. RodinH-Index: 2
#2Christian BengsH-Index: 7
Last. Malcolm H. LevittH-Index: 67
view all 9 authors...
Algorithmic cooling methods manipulate an open quantum system in order to lower its temperature below that of the environment. We show that significant cooling is achieved on an ensemble of spin-pair systems by exploiting the long-lived nuclear singlet state, which is an antisymmetric quantum superposition of the "up" and "down" qubit states. The effect is demonstrated by nuclear magnetic resonance (NMR) experiments on a molecular system containing a coupled pair of near-equivalent 13C nuclei. T...
#1Bogdan A. Rodin (NSU: Novosibirsk State University)H-Index: 2
#1Bogdan A. Rodin (NSU: Novosibirsk State University)H-Index: 2
Last. Konstantin L. Ivanov (NSU: Novosibirsk State University)H-Index: 16
view all 9 authors...
Some nuclear spin systems support long-lived states, which display greatly extended relaxation times relative to the relaxation time of nuclear spin magnetization. In spin-1/2 pairs, such a long-lived state is given by singlet order, representing the difference of the population of the nuclear singlet state and the mean population of the three triplets. In many cases, the experiments with long-lived singlet order are very time-consuming because of the need to wait for singlet order decay before ...
2 CitationsSource
#1Jiafei Mao (Goethe University Frankfurt)H-Index: 5
#2Victoria Aladin (University of Rostock)H-Index: 3
Last. Clemens Glaubitz (Goethe University Frankfurt)H-Index: 33
view all 9 authors...
Although the rapid development of sensitivity-enhanced solid-state NMR (ssNMR) spectroscopy based on dynamic nuclear polarization (DNP) has enabled a broad range of novel applications in material and life sciences, further methodological improvements are needed to unleash the full potential of DNP-ssNMR. Here, a new methyl-based toolkit for exploring protein structures is presented, which combines signal-enhancement by DNP with heteronuclear Overhauser effect (hetNOE), carbon–carbon-spin diffusi...
1 CitationsSource
#1Jagdeep Kaur (Goethe University Frankfurt)H-Index: 4
#2Clara Nassrin Kriebel (Goethe University Frankfurt)H-Index: 2
Last. Clemens Glaubitz (Goethe University Frankfurt)H-Index: 33
view all 12 authors...
Abstract Krokinobacter eikastus rhodopsin 2 (KR2) is a pentameric, light-driven ion pump, which selectively transports sodium or protons. The mechanism of ion selectivity and transfer is unknown. By using conventional as well as dynamic nuclear polarization (DNP)-enhanced solid-state NMR, we were able to analyse the retinal polyene chain between positions C10 and C15 as well as the Schiff base nitrogen in the KR2 resting state. In addition, 50% of the KR2 13C and 15N resonances could be assigned...
9 CitationsSource
#1Stuart J. Elliott (University of Southampton)H-Index: 8
#2Pavel Kadeřávek ('ENS Paris': École Normale Supérieure)H-Index: 7
Last. Malcolm H. Levitt (University of Southampton)H-Index: 67
view all 9 authors...
ABSTRACTA range of nuclear magnetic resonance spectroscopy and imaging applications are limited by the short lifetimes of magnetisation in solution. Long-lived states, which are slowly relaxing configurations of nuclear spins, have been shown to alleviate this limitation. Long-lived states have decay lifetimes significantly exceeding the longitudinal relaxation time , in some cases by an order of magnitude. Here we present an experimental case of a long-lived state for a 15N labelled molecular s...
7 CitationsSource
#1Kirill F. Sheberstov (University of Mainz)H-Index: 4
#1Kirill F. Sheberstov (University of Mainz)H-Index: 2
Last. Konstantin L. Ivanov (NSU: Novosibirsk State University)H-Index: 16
view all 10 authors...
We present approaches for an efficient excitation of singlet–triplet coherences in pairs of nearly-equivalent spins. Standard Nuclear Magnetic Resonance (NMR) pulse sequences do not excite these coherences at all or with very low efficiency. The single quantum singlet–triplet coherences, here termed the outer singlet–triplet coherences, correspond to lines of low intensity in the NMR spectrum of a strongly-coupled spin pair (they are sometimes referred to as “forbidden transitions”), whereas the...
7 CitationsSource
#1Stuart J. Elliott (University of Southampton)H-Index: 8
#2Christian Bengs (University of Southampton)H-Index: 7
Last. Malcolm H. Levitt (University of Southampton)H-Index: 67
view all 7 authors...
The singlet state of nuclear spin-1/2 pairs is protected against many common relaxation mechanisms. Singlet order, which is defined as the population difference between the nuclear singlet and triplet states, usually decays more slowly than the nuclear magnetization. Nevertheless, some decay mechanisms for nuclear singlet order persist. One such mechanism is called scalar relaxation of the second kind (SR2K) and involves the relaxation of additional nuclei (“third spins”) which have scalar coupl...
6 CitationsSource
#1Bogdan A. Rodin (NSU: Novosibirsk State University)H-Index: 2
#1Bogdan A. Rodin (NSU: Novosibirsk State University)H-Index: 2
Last. Konstantin L. Ivanov (NSU: Novosibirsk State University)H-Index: 16
view all 11 authors...
A method is implemented to perform "fast" adiabatic variation of the spin Hamiltonian by imposing the constant adiabaticity condition. The method is applied to improve the performance of singlet-state Nuclear Magnetic Resonance (NMR) experiments, specifically, for efficient generation and readout of the singlet spin order in coupled spin pairs by applying adiabatically ramped RF-fields. Test experiments have been performed on a specially designed molecule having two strongly coupled C-13 spins a...
8 CitationsSource
#1Alexander J. Leeder (University of Southampton)H-Index: 3
#2Lynda J. Brown (University of Southampton)H-Index: 18
Last. Richard C. D. Brown (University of Southampton)H-Index: 32
view all 6 authors...
Three all-trans retinals containing multiple 13 C labels have been synthesized to enable dynamic nuclear polarization enhanced solid-state magic angle spinning NMR studies of novel microbial retinylidene membrane proteins including proteorhodpsin and channelrhodopsin. The synthetic approaches allowed specific introduction of 13 C labels in ring substituents and at different positions in the polyene chain to probe structural features such as ring orientation and interaction of the chromophore wit...
3 CitationsSource
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