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Sonja Ilić
University of Niš
NephrotoxicityGentamicinKidneyBiochemistryPharmacology
19Publications
4H-index
51Citations
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Publications 19
Newest
#2Niko S. Radulović (University of Niš)H-Index: 26
Last. Sonja IlićH-Index: 4
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In this work we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens, 4-(alkylamino)-3-nitrocoumarins, as antianxiety agents, using a battery of in vivo experiments. Three chosen coumarin derivatives, differing in the substituent (sec-butylamino, hexadecylamino, or benzylamino) at position 4, at the doses of 25, 50 and 100 mg kg-1, were evaluated in light/dark, open-field, horizontal wire and diazepam-induced sleep model...
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#1Nenad Stojiljković (University of Niš)H-Index: 11
#2Sonja Ilić (University of Niš)H-Index: 4
Last. Milan Stoiljkovic (University of Niš)H-Index: 8
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Lycopene is one of the most potent antioxidants among carotenoids due to its ability to quench singlet oxygen and react with free radicals to reduce DNA damage. Methotrexate is widely used in the t...
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#1Sonja Ilić (University of Niš)H-Index: 4
#2Nenad Stojiljković (University of Niš)H-Index: 11
Last. Nikola M. Stojanović (University of Niš)H-Index: 11
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Since cisplatin-induced nephrotoxicity has very important clinical consequences, the purpose of this study was to determine the potential protective effect of aminoguanidine on the acute kidney inj...
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#1Pavle J. Randjelović (University of Niš)H-Index: 12
#2Nenad Stojiljković (University of Niš)H-Index: 11
Last. Sonja Ilić (University of Niš)H-Index: 4
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ABSTRACTAbout a third of adults have sleep problems, while in the student population this number is much higher due to a specific lifestyle. It has been shown that the use of devices with light-emi...
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#1Nikola M. Stojanović (University of Niš)H-Index: 11
#2Pavle J. Randjelović (University of Niš)H-Index: 12
Last. Niko S. Radulović (University of Niš)H-Index: 26
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Abstract Despite being renowned for its volatiles, the data on the toxicity of the essential oil of lemon balm (Melissa officinalis L., Lamiaceae) is rather limited compared to its solvent/water-soluble extractibles. In this study, the aerial parts essential oil of M. officinalis, with over 130 constituents identified herein, 26 of which detected for the first time, was investigated for acute oral toxicity in BALB/c mice. The oil, composed of predominantly monoterpene aldehydes, citronellal (21....
1 CitationsSource
#1Nenad Stojiljković (University of Niš)H-Index: 11
#2Sonja Ilić (University of Niš)H-Index: 4
Last. Milan Petković (University of Niš)
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In this study, we aimed to evaluate whether the encapsulation of ellagic acid (EA) into nanoliposomes would improve its potential in preventing cyclophosphamide-induced liver damage. Stability and antioxidative potential of free and encapsulated EA were determined. Experimental study conducted in vivo included ten groups of rats treated with cyclophosphamide and ellagic acid in its free and encapsulated form during 5 days. The protective effect of EA in its free and encapsulated form was determi...
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Background and objectives: Dysregulation of TGF-β signaling plays multiple roles in cancer development and progression. In the canonical TGF-β pathway, TGF-β regulates the expression of hundreds of target genes via interaction with Smads, signal transducers and transcriptional modulators. We evaluated the association of TGF-β1, Smad2, and Smad4, the key components of canonical TGFβ pathway, with clinicopathologic characteristics of urothelial bladder cancer, and assessed their prognostic value i...
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#1Nikola M. Stojanović (University of Niš)H-Index: 11
#2Pavle J. Randjelović (University of Niš)H-Index: 12
Last. Niko S. Radulović (University of Niš)H-Index: 26
view all 7 authors...
Anxiety disorders are among the most frequent psychiatric diseases, with around ¼ of the World population suffering from these disorders during their lifetimes. Besides psyche-related symptoms, these patients can have a large number of somatic symptoms as well. Although the treatment of these disorders is mainly focused on resolving its mental component, one cannot neglect the need for the treatment of accompanying somatic symptoms. Melissa officinalis L. (lemon balm), in various formulations, h...
#1Nenad Stojiljković (University of Niš)H-Index: 11
#2Sonja Ilić (University of Niš)H-Index: 4
Last. Gordana Kocic (University of Niš)H-Index: 16
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Methotrexate is an antimetabolic drug with a myriad of serious side effects including nephrotoxicity, which presumably occurs due to oxidative tissue damage. Here, we evaluated the potential protective effect of lycopene, a potent antioxidant carotenoid, given in two different pharmaceutical forms in methotrexate-induced kidney damage in rats. Serum biochemical (urea and creatinine) and tissue oxidative damage markers and histopathological kidney changes were evaluated after systemic administrat...
3 CitationsSource
#1Nenad StojiljkovićH-Index: 11
#2Sonja IlićH-Index: 4
Last. Marko Z. Mladenović (University of Niš)H-Index: 6
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We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by thi...
2 CitationsSource
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