Match!
Wieneke Dijk
Wageningen University and Research Centre
EndocrinologyWhite adipose tissueAdipose tissueBiologyLipoprotein lipase
21Publications
10H-index
437Citations
What is this?
Publications 23
Newest
#1Xanthe A. M. H. van Dierendonck (Radboud University Nijmegen)H-Index: 2
#2Montserrat A. de la Rosa Rodriguez (WUR: Wageningen University and Research Centre)H-Index: 3
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 10 authors...
Summary Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced adipose-tissue inflammation, using mice with myeloid-specific deficiency of the lipid-inducible HILPDA protein. HILPDA deficiency markedly reduced intracellular lipid levels and accumulation of fluorescently labeled fatty acids. Decreased lipid st...
2 CitationsSource
#1Antwi-Boasiako Oteng (WUR: Wageningen University and Research Centre)H-Index: 2
Last. Sander KerstenH-Index: 67
view all 8 authors...
ANGPTL4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric lymphadenopathy. Here, we studied the role of ANGPTL4 in lipid uptake in macrophages and in the above-mentioned pathologies using Angptl4-hypomorphic and Angptl4-/- mice. Angptl4 expression in peritoneal and bone marrow-derived macrophages was highly induced by lipids. Recombinant ANG...
3 CitationsSource
#1X. A. M. H. van Dierendonck (WUR: Wageningen University and Research Centre)
#2M. A. de la Rosa Rodriguez (WUR: Wageningen University and Research Centre)
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 10 authors...
Obesity leads to a state of chronic low-grade inflammation that features the accumulation of lipid laden macrophages in adipose tissue. Here, we determined the role of lipid accumulation in macrophages in the development of obesity-induced adipose tissue inflammation and associated metabolic disturbances via modulation of the Hilpda gene. Hilpda was identified in a screen for obesity-induced genes in adipose tissue macrophages that are also upregulated by lipid loading. For further studies we us...
Source
#1Wieneke Dijk (WUR: Wageningen University and Research Centre)H-Index: 10
#2Philip M. M. Ruppert (WUR: Wageningen University and Research Centre)H-Index: 3
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 4 authors...
Lipoprotein lipase (LPL) catalyzes the breakdown of circulating triglycerides in muscle and fat. LPL is inhibited by several proteins, including angiopoietin-like 4 (ANGPTL4), and may be cleaved by members of the proprotein convertase subtilisin/kexin (PCSK) family. Here, we aimed to investigate the cleavage of LPL in adipocytes by PCSKs and study the potential involvement of ANGPTL4. A substantial portion of LPL in mouse and human adipose tissue was cleaved into N- and C-terminal fragments. Tre...
9 CitationsSource
#1Aldo GrefhorstH-Index: 20
Last. Jenny A. VisserH-Index: 39
view all 11 authors...
Cold exposure of mice is a common method to stimulate brown adipose tissue (BAT) activity and induce browning of white adipose tissue (WAT) that has beneficial effects on whole-body lipid metabolism, including reduced plasma triglyceride (TG) concentrations. The liver is a key regulatory organ in lipid metabolism as it can take up as well as oxidize fatty acids. The liver can also synthesize, store and secrete TGs in VLDL particles. The effects of cold exposure on murine hepatic lipid metabolism...
Source
#1Wieneke Dijk (WUR: Wageningen University and Research Centre)H-Index: 10
#2Sophie Schutte (WUR: Wageningen University and Research Centre)H-Index: 2
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 6 authors...
Background Elevated plasma triglycerides are increasingly viewed as a causal risk factor for coronary artery disease. One protein that raises plasma triglyceride levels and that has emerged as a modulator of coronary artery disease risk is angiopoietin-like 4 (ANGPTL4). ANGPTL4 raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL), the enzyme that catalyzes the hydrolysis of circulating triglycerides on the capillary endothelium. Objective The objective of the present study wa...
3 CitationsSource
#1Merel Defour (WUR: Wageningen University and Research Centre)H-Index: 1
#2Wieneke Dijk (WUR: Wageningen University and Research Centre)H-Index: 10
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 6 authors...
Abstract Objective Chronic cold exposure causes white adipose tissue (WAT) to adopt features of brown adipose tissue (BAT), a process known as browning. Previous studies have hinted at a possible role for the transcription factor Peroxisome Proliferator-Activated Receptor alpha (PPARα) in cold-induced browning. Here we aimed to investigate the importance of PPARα in driving transcriptional changes during cold-induced browning in mice. Methods Male wildtype and PPARα−/− mice were housed at thermo...
12 CitationsSource
#1Rosa van den Berg (LUMC: Leiden University Medical Center)H-Index: 5
#2Sander Kooijman (University of Oxford)H-Index: 3
Last. Patrick C. N. Rensen (LUMC: Leiden University Medical Center)H-Index: 46
view all 28 authors...
Summary Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression ...
12 CitationsSource
#1Aafke W. F. Janssen (WUR: Wageningen University and Research Centre)H-Index: 7
#2Wieneke Dijk (WUR: Wageningen University and Research Centre)H-Index: 10
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 8 authors...
Angiopoietin-like 4 (ANGPTL4) raises plasma triglyceride levels by inhibiting lipoprotein lipase. A set of compounds that are able to reduce plasma triglyceride levels are bile acids (BA). Because BA have been shown to decrease ANGPTL4 secretion by intestinal cells, we hypothesized that BA lower plasma triglycerides (partly) via ANGPTL4. To test that hypothesis, wild-type and Angptl4(-/-) mice were fed chow supplemented with taurocholic acid (TCA) for seven days. TCA supplementation effectively ...
6 CitationsSource
#1Aafke W. F. Janssen (WUR: Wageningen University and Research Centre)H-Index: 7
#2Tom Houben (UM: Maastricht University)H-Index: 8
Last. Sander Kersten (WUR: Wageningen University and Research Centre)H-Index: 67
view all 17 authors...
Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber guar gum and suppressing the gut bacteria via chronic oral administration of antibiotics. Guar gum feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced ob...
25 CitationsSource
123