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Wieneke Dijk
Wageningen University and Research Centre
20Publications
9H-index
373Citations
Publications 20
Newest
Published on Mar 5, 2019in bioRxiv
X. A. M. H. van Dierendonck (WUR: Wageningen University and Research Centre), M. A. de la Rosa Rodriguez (WUR: Wageningen University and Research Centre)+ 7 AuthorsSander Kersten65
Estimated H-index: 65
(WUR: Wageningen University and Research Centre)
Obesity leads to a state of chronic low-grade inflammation that features the accumulation of lipid laden macrophages in adipose tissue. Here, we determined the role of lipid accumulation in macrophages in the development of obesity-induced adipose tissue inflammation and associated metabolic disturbances via modulation of the Hilpda gene. Hilpda was identified in a screen for obesity-induced genes in adipose tissue macrophages that are also upregulated by lipid loading. For further studies we us...
Published on Sep 7, 2018in Journal of Biological Chemistry
Wieneke Dijk9
Estimated H-index: 9
(WUR: Wageningen University and Research Centre),
Philip Ruppert3
Estimated H-index: 3
(WUR: Wageningen University and Research Centre)
+ 1 AuthorsSander Kersten65
Estimated H-index: 65
(WUR: Wageningen University and Research Centre)
Lipoprotein lipase (LPL) catalyzes the breakdown of circulating triglycerides in muscle and fat. LPL is inhibited by several proteins, including angiopoietin-like 4 (ANGPTL4), and may be cleaved by members of the proprotein convertase subtilisin/kexin (PCSK) family. Here, we aimed to investigate the cleavage of LPL in adipocytes by PCSKs and study the potential involvement of ANGPTL4. A substantial portion of LPL in mouse and human adipose tissue was cleaved into N- and C-terminal fragments. Tre...
Published on Aug 1, 2018in Journal of Endocrinology4.38
Aldo Grefhorst20
Estimated H-index: 20
,
Johanna C. van den Beukel2
Estimated H-index: 2
+ 8 AuthorsAxel P. N. Themmen58
Estimated H-index: 58
Cold exposure of mice is a common method to stimulate brown adipose tissue (BAT) activity and induce browning of white adipose tissue (WAT) that has beneficial effects on whole-body lipid metabolism, including reduced plasma triglyceride (TG) concentrations. The liver is a key regulatory organ in lipid metabolism as it can take up as well as oxidize fatty acids. The liver can also synthesize, store and secrete TGs in VLDL particles. The effects of cold exposure on murine hepatic lipid metabolism...
Published on Mar 1, 2018in Cell Reports7.82
Rosa van den Berg5
Estimated H-index: 5
(LUMC: Leiden University Medical Center),
Sander Kooijman1
Estimated H-index: 1
(University of Oxford)
+ 25 AuthorsBarbara Kramar2
Estimated H-index: 2
(UCPH: University of Copenhagen)
Summary Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression ...
Published on Feb 1, 2018in Journal of Clinical Lipidology3.58
Wieneke Dijk9
Estimated H-index: 9
(WUR: Wageningen University and Research Centre),
Sophie Schutte1
Estimated H-index: 1
(WUR: Wageningen University and Research Centre)
+ 3 AuthorsSander Kersten65
Estimated H-index: 65
(WUR: Wageningen University and Research Centre)
Background Elevated plasma triglycerides are increasingly viewed as a causal risk factor for coronary artery disease. One protein that raises plasma triglyceride levels and that has emerged as a modulator of coronary artery disease risk is angiopoietin-like 4 (ANGPTL4). ANGPTL4 raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL), the enzyme that catalyzes the hydrolysis of circulating triglycerides on the capillary endothelium. Objective The objective of the present study wa...
Published on Feb 1, 2018in Molecular metabolism6.18
Merel Defour1
Estimated H-index: 1
(WUR: Wageningen University and Research Centre),
Wieneke Dijk9
Estimated H-index: 9
(WUR: Wageningen University and Research Centre)
+ 3 AuthorsSander Kersten65
Estimated H-index: 65
(WUR: Wageningen University and Research Centre)
Objective: Chronic cold exposure causes white adipose tissue (WAT) to adopt features of brown adipose tissue (BAT), a process known as browning. Previous studies have hinted at a possible role for the transcription factor Peroxisome Proliferator-Activated Receptor alpha (PPARα) in cold-induced browning. Here we aimed to investigate the importance of PPARα in driving transcriptional changes during cold-induced browning in mice. Methods: Male wildtype and PPARα-/- mice were housed at thermoneutral...
Published on Oct 1, 2017in Biochimica et Biophysica Acta3.79
Aafke W. F. Janssen6
Estimated H-index: 6
(WUR: Wageningen University and Research Centre),
Wieneke Dijk9
Estimated H-index: 9
(WUR: Wageningen University and Research Centre)
+ 5 AuthorsSander Kersten65
Estimated H-index: 65
(WUR: Wageningen University and Research Centre)
Abstract Angiopoietin-like 4 (ANGPTL4) raises plasma triglyceride levels by inhibiting lipoprotein lipase. A set of compounds that are able to reduce plasma triglyceride levels are bile acids (BA). Because BA have been shown to decrease ANGPTL4 secretion by intestinal cells, we hypothesized that BA lower plasma triglycerides (partly) via ANGPTL4. To test that hypothesis, wild-type and Angptl4 −/− mice were fed chow supplemented with taurocholic acid (TCA) for seven days. TCA supplementation effe...
Published on Jul 1, 2017in Journal of Lipid Research4.74
Aafke W. F. Janssen6
Estimated H-index: 6
(WUR: Wageningen University and Research Centre),
Tom Houben7
Estimated H-index: 7
(UM: Maastricht University)
+ 14 AuthorsStéphane Mandard17
Estimated H-index: 17
(CNRS: Centre national de la recherche scientifique)
Non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber guar gum and suppressing the gut bacteria via chronic oral administration of antibiotics. Guar gum feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced ob...
Published on May 1, 2017in Endocrinology3.80
Wieneke Dijk9
Estimated H-index: 9
(WUR: Wageningen University and Research Centre),
Frits Mattijssen10
Estimated H-index: 10
(WUR: Wageningen University and Research Centre)
+ 7 AuthorsSander Kersten65
Estimated H-index: 65
(UM: University of Michigan)
Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, the protein hypoxia-inducible lipid droplet-associated (HILPDA) was localized to lipid droplets and was suggested to inhibit triglyceride lipolysis in hepatocytes. We confirm the partial localization of HILPDA to lipid droplets and show that HILPDA is highly abundant in adipose tissue, where its expressi...
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