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Yingbo Lin
Karolinska Institutet
Molecular biologyCell cycleCancer researchCell growthBiology
13Publications
6H-index
147Citations
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Publications 14
Newest
#1Yi Chen (KI: Karolinska Institutet)H-Index: 1
#2Asle Hesla (KI: Karolinska Institutet)H-Index: 3
Last. Felix Haglund (KI: Karolinska Institutet)H-Index: 10
view all 10 authors...
Ewing sarcomas (ESs) are aggressive sarcomas driven by EWS fusion genes. We sought to investigate whether whole-transcriptome sequencing (RNA-seq) could be used to detect patterns associated with chemotherapy response or tumor progression after first-line treatment. Transcriptome sequencing (RNA-seq) of 13 ES cases was performed. Among the differentially expressed pathways, we identified IGF2 expression as a potential driver of chemotherapy response and progression. We investigated the effect of...
Source
#1Bushan Xie (Uppsala University)H-Index: 1
#2Xingxing He (NCU: Nanchang University)H-Index: 1
Last. Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
view all 7 authors...
Abstract The use of highly efficient high-throughput screening (HTS) platform has recently gained more attention as a plausible approach to identify de novo therapeutic application potential of conventional anti-tumor drugs for cancer treatments. In this study, we used hepatocellular carcinoma (HCC) cells as models to identify cytotoxic compounds by HTS. To identify cytotoxic compounds for potential HCC treatments, 3271 compounds from three well established small molecule libraries were screened...
2 CitationsSource
#1Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
#2Nelly Seger (KI: Karolinska Institutet)H-Index: 1
Last. Felix Haglund (KI: Karolinska Institutet)H-Index: 10
view all 9 authors...
Chondrosarcomas are malignant skeletal tumors with chondroid differentiation. Prognosis is largely dependent on histological grading, which suffer from significant interobserver variability. Telomerase activity and abundant telomerase reverse transcriptase (hTERT) expression has previously been associated with chondrosarcoma grade and metastasis. We therefore analyzed the hTERT promoter in clinicopathologically well-characterized chondrosarcomas (grade 1–3) from 87 patients. Using Sanger sequenc...
Source
#1Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
#2Hermine A van Duyvenvoorde (Loyola University Medical Center)H-Index: 1
Last. Olle Larsson (KI: Karolinska Institutet)H-Index: 49
view all 10 authors...
3 CitationsSource
#1Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
#2Nelly Seger (KI: Karolinska Institutet)H-Index: 1
Last. Felix HaglundH-Index: 10
view all 11 authors...
Aims Solitary fibrous tumour (SFT) is an infrequently metastasising mesenchymal tumour defined by the NAB2–STAT6 fusion gene. Activating mutations in the telomerase reverse transcriptase ( hTERT ) gene promoter has been reported to associate with adverse patient outcome in SFTs. Methods We analysed the hTERT gene for promoter mutations and copy number alterations in 43 primary extrameningeal SFTs (9 malignant and 34 benign tumours according to WHO 2013 criteria), six local recurrences and three ...
3 CitationsSource
#1Ahmed Waraky (KI: Karolinska Institutet)H-Index: 4
#2Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
Last. Olle Larsson (KI: Karolinska Institutet)H-Index: 49
view all 6 authors...
We have previously shown that the insulin like growth factor 1 receptor (IGF1R) translocates to the cell nucleus, where it binds to enhancer like regions and increases gene transcription. Further studies have demonstrated that nuclear IGF1R (nIGF1R) physically and functionally interacts with some nuclear proteins, i.e. the lymphoid enhancer binding factor 1 (Lef1), histone H3, and Brahma related gene 1 proteins. In the present study, we identified the proliferating cell nuclear antigen (PCNA) as...
6 CitationsSource
#1Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
#2Hongyu LiuH-Index: 2
Last. Olle Larsson (KI: Karolinska Institutet)H-Index: 49
view all 8 authors...
Increasing number of studies have shown nuclear localization of the insulin-like growth factor 1 receptor (nIGF-1R) in tumor cells and its links to adverse clinical outcome in various cancers. Any obvious cell physiological roles of nIGF-1R have, however, still not been disclosed. Previously, we reported that IGF-1R translocates to cell nucleus and modulates gene expression by binding to enhancers, provided that the receptor is SUMOylated. In this study, we constructed stable transfectants of wi...
9 CitationsSource
#1Ahmed Waraky (KI: Karolinska Institutet)H-Index: 4
#2Yingbo Lin (KI: Karolinska Institutet)H-Index: 6
Last. Olle Larsson (KI: Karolinska Institutet)H-Index: 49
view all 4 authors...
Background: The type 1 insulin-like growth factor receptor (IGF-1R) and its signaling components promote cell proliferation, survival, and development of the malignant phenotype. Recently, the IGF-1R has been shown to translocate to the nucleus; however its nuclear functions are not fully elucidated. The proliferating cell nuclear antigen (PCNA) is a nuclear protein that coordinates DNA replication, and is involved in DNA damage repair and in the DNA damage tolerance (DDT) pathways. DDT allows t...
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#1Thomas Strömberg (Uppsala University)H-Index: 11
#2Xiaoying Feng (KI: Karolinska Institutet)H-Index: 2
Last. Gunilla Enblad (Uppsala University)H-Index: 35
view all 10 authors...
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. Although chemotherapy in combination with anti-CD20 antibodies results in a cure rate of 60–70 %, novel treatment approaches are warranted for the remaining patients. The insulin-like growth factor-1 receptor (IGF-1R) and its principal ligands IGF-1 and IGF-2 have been suggested to play pivotal roles in different cancers. However, in DLBCL the importance of this system is less well understood. To assess whether interfer...
7 CitationsSource
#1S. Packham (KI: Karolinska Institutet)H-Index: 1
#2Dudi Warsito (KI: Karolinska Institutet)H-Index: 5
Last. Olle Larsson (KI: Karolinska Institutet)H-Index: 49
view all 7 authors...
Nuclear translocation of IGF-1R via p150 Glued and an importin-β/RanBP2-dependent pathway in cancer cells
17 CitationsSource
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