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Shaik Nyamathulla
University of Malaya
ChemistrySwellingChromatographyGranulationPharmacology
21Publications
4H-index
61Citations
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Publications 21
Newest
#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 6 authors...
Abstract We previously reported that insulin-entrapped chitosan complexed carboxymethylated iota-carrageenan (CS/CMCi) particles exhibit pH-responsive swelling behavior. However, the particles’ stability in the enzymatic gastrointestinal environment, their drug permeability mechanism, and related in vivo studies have not been discussed to date. In this study, we investigated the stability, muco-adhesiveness, transport mechanism and in vivo assessment of the particles. The particles retained thei...
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#1Nur Amanina Syariff Tan (UM: University of Malaya)H-Index: 1
#2Nelli Giribabu (UM: University of Malaya)H-Index: 10
Last. Naguib Salleh (UM: University of Malaya)H-Index: 14
view all 5 authors...
Abstract Ethnopharmacological relevance Marantodes pumilum (MP) (Kacip Fatimah) is used to maintain the well-being of post-menopausal women. However, its role in ameliorating post menopause-related vaginal atrophy (VA) is unknown. Aims To investigate the ability of intravaginal MP gel treatment to ameliorate VA in sex-steroid deficient condition, mimicking post-menopause. Methods Ovariectomized female Sprague-Dawley rats received MP (100 μg/ml, 250 μg/ml and 500 μg/ml) and estriol (E) gels intra...
1 CitationsSource
#1Yasir Osman Ali Abdalla (UM: University of Malaya)H-Index: 1
#2Shaik Nyamathulla (UM: University of Malaya)H-Index: 4
Last. Noor Hasima Nagoor (UM: University of Malaya)H-Index: 10
view all 7 authors...
Abstract 1′-S-1′-acetoxychavicol acetate (ACA) has been previously reported to reduce tumor volume in nude mice, at an effective dose of 1.56 mg/kg body weight. However, the detailed toxicological profile for ACA has not yet been performed. Herein, we investigated the toxicity of intravenous administration of ACA in male and female Sprague-Dawley rats, both acutely (with single doses of 2.00, 4.00 and 6.66 mg/kg body weight, for 14 days), and sub-acutely (with weekly injections of 0.66, 1.33, an...
3 CitationsSource
1 CitationsSource
#1Elham Bagheri (UM: University of Malaya)H-Index: 3
#2Fatemeh Hajiaghaalipour (UM: University of Malaya)H-Index: 7
Last. N. A. Salehen (UM: University of Malaya)H-Index: 1
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Brucea javanica (L.) Merr. is a well-known plant in Chinese System of Medicine. Its fruits and seeds have been reported to possess curative properties against various ailments. The chemical constituents and biological activity of this plant have been an interesting area in plant and chemistry medicine. The aim of this study is to evaluate the antiproliferative effects of the B. javanica extract against a colon cancer cell line and identification of the chemical components derived from the extrac...
3 CitationsSource
#1Pratyusa Sahoo (UM: University of Malaya)H-Index: 1
#2Kok Hoong Leong (UM: University of Malaya)H-Index: 10
Last. Lip Yong Chung (UM: University of Malaya)H-Index: 19
view all 6 authors...
Abstract In designing an oral delivery method for insulin, we previously reported that pH-responsive carboxymethylated kappa -carrageenan-based microparticles protected insulin from acid degradation during transport through the gastrointestinal tract. However, the low surface-to-volume ratio of these microparticles and the presence of only one sulfate group in each kappa -carrageenan subunit for insulin stabilization may lead to a suboptimal delivery efficiency. To improve the delivery efficienc...
4 CitationsSource
#1Mohd. Shakrie Palan Abdullah (UM: University of Malaya)H-Index: 2
#2Mohamed Ibrahim Noordin (UM: University of Malaya)H-Index: 12
Last. Ahmad Fuad ShamsuddinH-Index: 4
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Growing needs, inadequate supply along with health and religious issues are reasons for the increase in the demand for an alternative source of gelatine in the food and pharmaceutical industries. This study was conducted to optimize the process for producing halal-compliant gelatine from chicken waste; chicken shank and toes (CST). Double extraction process employed produced gelatine which was vitreous, lightweight and gossamer in appearance. Gelatine yield was 9.52%(w/w) with a pH of 3.85, mois...
2 Citations
The present research was aimed at formulating a metformin HCl sustained-release formulation from a combination of polymers, using the wet granulation technique. A total of 16 formulations (F1–F16) were produced using different combinations of the gel-forming polymers: tamarind kernel powder, salep (palmate tubers of Orchis morio), and xanthan. Post-compression studies showed that there were no interactions between the active drug and the polymers. Results of in vitro drug-release studies indicat...
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The purpose of this study is to evaluate the in vitro and in vivo performance of gastro-retentive matrix tablets having Metformin HCl as model drug and combination of natural polymers. A total of 16 formulations were prepared by a wet granulation method using xanthan, tamarind seed powder, tamarind kernel powder and salep as the gel-forming agents and sodium bicarbonate as a gas-forming agent. All the formulations were evaluated for compendial and non-compendial tests and in vitro study was carr...
3 CitationsSource
#1Mahboubeh RazaviH-Index: 6
#2Shaik NyamathullaH-Index: 4
Last. Mohamed Ibrahim NoordinH-Index: 12
view all 5 authors...
The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for ...
4 CitationsSource
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