Gregory D. Kirk
Johns Hopkins University
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Publications 261
#1Martin Tibaukuu (Mount Sinai St. Luke's and Mount Sinai Roosevelt)
#2Caroline Jjingo (NIH: National Institutes of Health)
Last. Christopher Kenneth Opio (MUK: Makerere University)H-Index: 7
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Liverfibrosismay beassessed non-invasively with transient electrography (TE). Data on the performance of TE for detecting liver fibrosis in sub-Saharan Africa are limited.We evaluated the diagnostic accuracy of TE by performing liver biopsies on persons with liver fibrosis indicated by TE. We enrolled HIV-infected and HIV-uninfected participants with TE scores consistent with at least minimal disease (liver stiffness measurement [LSM]>/=7.1kPa). Biopsieswere performed and staged using the Ishak ...
#1Damani Arnold Piggott (Johns Hopkins University)H-Index: 8
#2Karen Bandeen-RocheH-Index: 65
Last. Gregory D. KirkH-Index: 49
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OBJECTIVE: Frailty is a critical aging-related syndrome marked by diminished physiologic reserve and heightened vulnerability to stress, predictive of major adverse clinical outcomes in HIV-infected and uninfected adults. Frailty is a dynamic state, yet little data exist on predictors and consequences of frailty transitions. DESIGN/METHODS: Frailty was assessed semiannually among HIV-infected and uninfected persons with prior injection drug use (PWID) using the 5 Fried phenotype domains. An infl...
#1Bisrat J Debebe (Imperial College London)H-Index: 1
#2Lies Boelen (Imperial College London)H-Index: 13
Last. James J. GoedertH-Index: 98
view all 11 authors...
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms in the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8(+) T cell responses which are restricted by the host HLA class I allotype. However, given the diverse receptors which are bound by HLA cl...
1 CitationsSource
#1Kassem Bourgi (IU: Indiana University)
#1Kassem Bourgi (VUMC: Vanderbilt University Medical Center)H-Index: 3
Last. Michael A. Horberg (KP: Kaiser Permanente)H-Index: 40
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INTRODUCTION: Weight gain following antiretroviral therapy (ART) initiation is common, potentially predisposing some persons with HIV (PWH) to cardio-metabolic disease. We assessed relationships between ART drug class and weight change among treatment-naive PWH initiating ART in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). METHODS: Adult, treatment-naive PWH in NA-ACCORD initiating integrase strand transfer inhibitor (INSTI), protease inhibitor (PI) or non-nuc...
2 CitationsSource
#1Denali Boon (Johns Hopkins University)H-Index: 5
#2Veronica Bruce (UNM: University of New Mexico)H-Index: 1
Last. Gregory D. Kirk (Johns Hopkins University)H-Index: 49
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BACKGROUND & AIMS: Accurate hepatitis C virus (HCV) incidence estimates are critical for monitoring progress towards HCV elimination goals, including an 80% reduction in HCV incidence by 2030. Moreover, incidence estimates can help guide prevention and treatment programming, particularly in the context of the US opioid epidemic. METHODS: An inexpensive, Genedia-based HCV IgG antibody avidity assay was evaluated as a platform to estimate cross-sectional, population-level primary HCV incidence usi...
#1Megan E. Buresh (Johns Hopkins University)H-Index: 1
#2Rachel E. Gicquelais (Johns Hopkins University)H-Index: 2
Last. Becky Genberg (Johns Hopkins University)H-Index: 20
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Introduction Overdose is a leading cause of death in the United States, especially among people who inject drugs (PWID). Improving naloxone access and carrying among PWID may offset recent increases in overdose mortality associated with the influx of synthetic opioids in the drug market. This study characterized prevalence and correlates of several naloxone outcomes among PWID. Methods During 2018, a survey to assess experience with naloxone was administered to 915 participants in the AIDS Linke...
#1Gregory D. KirkH-Index: 49
#2Hemali MehtaH-Index: 55
Last. David L. ThomasH-Index: 90
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It has been postulated that HIV infection accelerates hepatitis C virus (HCV)–related liver disease. This cohort study followed persons with HCV infection prospectively to compare the progression o...
#1Bohdan Nosyk (SFU: Simon Fraser University)H-Index: 24
#2Xiao Zang (SFU: Simon Fraser University)H-Index: 4
Last. Matthew R. Golden (UW: University of Washington)H-Index: 41
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Summary Background The HIV epidemic in the USA is a collection of diverse local microepidemics. We aimed to identify optimal combination implementation strategies of evidence-based interventions to reach 90% reduction of incidence in 10 years, in six US cities that comprise 24·1% of people living with HIV in the USA. Methods In this economic modelling study, we used a dynamic HIV transmission model calibrated with the best available evidence on epidemiological and structural conditions for six U...
1 CitationsSource
#1Raúl U. Hernández-Ramírez (Yale University)H-Index: 14
#2Li Qin (Yale University)H-Index: 3
Last. Sally CoburnH-Index: 2
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BACKGROUND: People living with human immunodeficiency virus (HIV; PLWH) have a markedly elevated anal cancer risk, largely due to loss of immunoregulatory control of oncogenic human papillomavirus infection. To better understand anal cancer development and prevention, we determined whether recent, past, cumulative, or nadir/peak CD4+ T-cell count (CD4) and/or HIV-1 RNA level (HIV RNA) best predict anal cancer risk. METHODS: We studied 102 777 PLWH during 1996-2014 from 21 cohorts participating i...
3 CitationsSource
#1Bisrat J Debebe (Imperial College London)H-Index: 1
#2Lies Boelen (Imperial College London)H-Index: 13
Last. Mubiana Inambao (Emory University)H-Index: 11
view all 26 authors...