Andrew J. Fisher
Newcastle University
Intensive care medicineLungLung transplantationTransplantationMedicine
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Publications 353
#1Jenny Gilmour (Newcastle University)
#2C.P. Griffiths (Newcastle University)
Last. Andrew J. Fisher (Newcastle University)H-Index: 34
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PURPOSE OF REVIEW: Lung transplantation offers the only realistic therapeutic option for patients with end-stage lung disease. However, this is impacted by a shortfall in availability of suitable donor-lungs. Normothermic machine perfusion of donor-lungs outside the donor body also known as ex-vivo lung perfusion (EVLP) offers a potential solution through objective assessment, reconditioning and treatment of donor-lungs initially deemed unsuitable for use. This review discusses key advances and ...
Purpose Transplant programmes are increasingly considering extended criteria donors, including previous smokers and older-age donors. In January 2018, the UK lung donor offering criteria was increased to 74 years (74 years and 364 days) for both DBD and DCD lung donors, where the donor was a life-time non-smoker or had not smoked within the last 10 years. Prior to this, the upper age limit was 64 years for DCD donors and 69 years for DBD donors. This study aims to assess the impact of the UK ext...
Purpose The number of potential donors after circulatory death (DCD) in the UK is increasing. DCD lung transplantation commenced in the UK in 2002 and is performed in 5 UK lung transplant centres. The aim of this study is to review the UK experience in lung utilisation and transplantation in DCD lung transplant. Methods Data on all adult lung offers (where at least 1 solid organ was donated) and transplants performed in the UK, between December 2002 and December 2018 were obtained from the UK Do...
#1Delphine Guillotin (UCL: University College London)H-Index: 1
#2Adam Taylor (GSK: GlaxoSmithKline)H-Index: 6
Last. Robert E. Hynds (UCL: University College London)H-Index: 12
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Fibroblastic foci (FF) represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple fibrotic conditions. The aim of this study was to define the major transcriptional programmes involved in fibrogenesis in IPF by profiling un-manipulated myo/fibroblasts within FF in situ by laser capture microdissection. The challenges associate...
#1Andrew J. Peacock (Golden Jubilee National Hospital)H-Index: 45
#1Andrew PeacockH-Index: 21
Last. Karen Sheares (Papworth Hospital)H-Index: 20
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#1Jack LeslieH-Index: 5
#2Ben MillarH-Index: 2
Last. Jack GauldieH-Index: 94
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Neutrophils are the most abundant inflammatory cells at the earliest stages of wound healing and play important roles in wound repair and fibrosis. Formyl peptide receptor 1 (FPR-1) is abundantly expressed on neutrophils and has been shown to regulate their function, yet the importance of FPR-1 in fibrosis remains ill defined. FPR-1-deficient (fpr1-/-) mice were protected from bleomycin-induced pulmonary fibrosis but developed renal and hepatic fibrosis normally. Mechanistically, we observed a f...
1 CitationsSource
#1Chelsea Griffiths (Newcastle University)
#1C.P. Griffiths (Newcastle University)
Last. Andrew J. Fisher (Newcastle University)H-Index: 34
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Currently, there is a shortfall in the number of suitable organs available for transplant resulting in a high number of patients on the active transplant waiting lists worldwide. To address this shortfall and increase the utilisation of donor organs, the acceptance criteria for donor organs is gradually expanding including increased use of organs from donation after circulatory death (DCD). Use of such extended criteria donors and exposure of organs to more prolonged periods of warm or cold isch...
#1Peter S. Cunningham (University of Manchester)H-Index: 4
#2Peter Meijer (University of Manchester)H-Index: 1
Last. John Blaikley (University of Manchester)H-Index: 11
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Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms resulting in a gain of amplitude and lack of synchrony within pulmonary fibrotic tissue. These changes result from an infiltration of mesenchymal cells, an important cell type in the pathogenesis of pulmonary fibrosis. Mutation of the core clock protein REVERBα in these cells e...
1 CitationsSource
#1Stephen O'NeillH-Index: 17
#2Sanket SrinivasaH-Index: 1
Last. Gabriel C. OniscuH-Index: 13
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This review article focuses on current clinical outcomes with novel perfusion strategies in organ transplantation. Broadly, these approaches can be divided into in-situ regional perfusion in the donor and ex-situ machine perfusion of individual organs. In both settings hypothermic and normothermic techniques are in clinical use. Evidence from full text articles, abstracts and data presented at scientific meetings has been considered. Animal studies have been excluded. The review focuses on kidne...
1 CitationsSource
#1Muzamil Majid KhanH-Index: 10
#2Daniel PoeckelH-Index: 5
Last. Rainer PepperkokH-Index: 70
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Fibrosis can affect any organ resulting in the loss of tissue architecture and function with often life-threatening consequences. Pathologically, fibrosis is characterised by expansion of connective tissue due to excessive deposition of extracellular matrix proteins (ECM), including the fibrillar forms of collagen. A significant hurdle for discovering cures for fibrosis is the lack of suitable models and techniques to quantify mature collagen deposition in tissues. Here we have extensively chara...