Dong Nyoung Heo
Kyung Hee University
Publications 61
Abstract Osseointegration is important in osteopenia and osteoporosis patients due to their low bone densities. Gold nanoparticles (GNPs) are greatly beneficial materials as osteogenic agents. The aim of this study is to investigate osseointegration between bones and double layers of GNP-immobilized titanium (Ti) implants. The physicochemical properties of the Ti surface were evaluated by scanning electron microscopy, by atomic force microscopy, by means of the contact angle using water drops, a...
#1Haram Nah (Kyung Hee University)H-Index: 2
#2Dong Hyun Lee (Kyung Hee University)H-Index: 27
Last.Il Keun Kwon (Kyung Hee University)H-Index: 38
view all 12 authors...
ABSTRACTIn an aging society, bone disorders such as osteopenia, osteoporosis, and degenerative arthritis cause serious public health problems. In order to solve these problems, researchers continue...
#1Jae Seo Lee (Kyung Hee University)H-Index: 2
#2Sang Jin Lee (Kyung Hee University)H-Index: 17
Last.Il Keun Kwon (Kyung Hee University)H-Index: 38
view all 11 authors...
Abstract Titanium implants (Ti) have been widely used in several medical fields. In clinical practice, Ti can become contaminated with bacteria through a variety of mechanisms. This contamination can lead to implant failure and serious infections. In this study, we aimed to develop a new, hybrid Ti with good biocompatibility and antibacterial properties by immobilizing ceftazidime (CFT) onto the Ti surface through polydopamine (PDA) and polyethyleneimine (PEI) chemistry. Hybrid Ti was confirmed ...
2 CitationsSource
#1Kazim K. Moncal (PSU: Pennsylvania State University)H-Index: 6
#2R. Seda Tigli Aydin (Zonguldak Karaelmas University)H-Index: 1
Last.Ibrahim T. OzbolatH-Index: 25
view all 9 authors...
Abstract Differentiation of progenitors in a controlled environment improves the repair of critical-sized calvarial bone defects; however, integrating micro RNA (miRNA) therapy with 3D printed scaffolds still remains a challenge for craniofacial reconstruction. In this study, we aimed to engineer three-dimensional (3D) printed hybrid scaffolds as a new ex situ miR-148b expressing delivery system for osteogenic induction of rat bone marrow stem cells (rBMSCs) in vitro, and also in vivo in critica...
2 CitationsSource
#1Dong Nyoung Heo (Kyung Hee University)H-Index: 18
#2Han-Jun Kim (Konkuk University)
Last.Sun Hee Do (Konkuk University)H-Index: 14
view all 8 authors...
Abstract Articular cartilage exhibits reduced self-healing following degeneration. This research evaluated the effects of hydrogels derived from various polysaccharides—gellan gum (GG), alginate, and agarose—on cartilage regeneration compared with that of hyaluronic acid (HA), which is commonly used in cartilage tissue engineering. Chondrocytes were isolated from the articular cartilage of New Zealand White (NZW) rabbits and stimulated with IL-1β followed by incubation with polysaccharides. The ...
#1Seong Jun KimH-Index: 2
#2Wan-Kyu KoH-Index: 12
Last.Seil SohnH-Index: 10
view all 9 authors...
Abstract Spinal cord injury (SCI) causes permanent nerve damage by disturbing axon regeneration from pro-inflammations and still remains a serious worldwide problem. Ursodeoxycholic acid (UDCA) has been reported that it can serve as an anti-neuroinflammatory drug such as Methylprednisolone (MP). However, the therapeutic effect of UDCA is limited due to its hydrophobic property. In this study, we aimed to investigate the anti-neuroinflammatory effects of gold nanoparticles (GNPs) loading UDCA (GN...
#1Dong Nyoung Heo (PSU: Pennsylvania State University)H-Index: 18
#2Monika Hospodiuk (PSU: Pennsylvania State University)H-Index: 5
Last.Ibrahim T. OzbolatH-Index: 25
view all 3 authors...
Abstract Stem cell encapsulation in hydrogels has been widely employed in tissue engineering, regenerative medicine, organ-on-a-chip devices and gene delivery; however, fabrication of native-like bone tissue using such a strategy has been a challenge, particularly in vitro, due to the limited cell loading densities resulting in weaker cell-cell interactions and lesser extra-cellular matrix deposition. In particular, scalable bone tissue constructs require vascular network to provide enough oxyge...
1 CitationsSource
#1Yun Hee Youn (European Institute)H-Index: 1
#2Sang Jin Lee (Kyung Hee University)H-Index: 17
Last.Il Keun Kwon (Kyung Hee University)H-Index: 38
view all 13 authors...
Abstract Over the past few decades, titanium (Ti) implants have been widely used to repair fractured bones. To promote osteogenesis, immobilization of osteoinductive agents, such as recombinant human bone morphogenic protein-2 (rhBMP2), onto the Ti surface is required. In this study, we prepared rhBMP2 immobilized on glycidyl methacrylate (GMA) deposited Ti surface through initiated chemical vapor deposition (iCVD) technique. After preparation, the bio-functionalized Ti surface was characterized...
1 CitationsSource
#1Dong Nyoung Heo (GW: George Washington University)H-Index: 18
#2Se-Jun Lee (GW: George Washington University)H-Index: 12
Last.ZhangLijie Grace (GW: George Washington University)H-Index: 29
view all 6 authors...
Abstract Bioelectronic devices enable efficient and effective communication between medical devices and human tissue in order to directly treat patients with various neurological disorders. Due to the mechanical similarity to human tissue, hydrogel-based electronic devices are considered to be promising for biological signal recording and stimulation of living tissues. Here, we report the first three-dimensionally (3D) printable conductive hydrogel that can be photocrosslinked while retaining hi...
3 CitationsSource
#1Dong Hyun Lee (Kyung Hee University)H-Index: 27
#2Eun Ji Choi (Konkuk University)H-Index: 1
Last.Il Keun Kwon (Kyung Hee University)H-Index: 38
view all 15 authors...
Abstract Maintaining appropriate mechanical strength and tissue volume is important to provide for sufficient alveolar bone growth. Recently, synthetic bone graft materials (BGM) including hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) have been widely studied for alveolar bone regeneration. Here, we applied gelatin-methacrylate (GelMA) hydrogel into the β-TCP to produce a GelMA/β-TCP composite (GelMA-B). This reinforced the mechanical strength and regulated the absorption period of β...
1 CitationsSource