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Dong Nyoung Heo
Kyung Hee University
Self-healing hydrogelsComposite materialMaterials scienceBone tissueNanofiber
59Publications
18H-index
1,255Citations
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Publications 67
Newest
#1Sang Jin Lee (Kyung Hee University)H-Index: 17
#2Haram Nah (Kyung Hee University)H-Index: 2
Last. Seong Young An (Kyung Hee University)
view all 17 authors...
Abstract Graphene oxide (GO) incorporated hydrogels have received great attention and have shown excellent potential for use in the field of bone tissue engineering due to their unique osteogenic functionalities. However, current hydrogel systems are limited in their ability to provide an appropriate amount of GO to the lesion area. To overcome this issue, we designed a GO incorporated glycol chitosan (gC)-hyaluronic acid (HA) injectable hydrogel system via a simple oxidation technique. Through ...
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#1Dong Nyoung Heo (Kyung Hee University)H-Index: 18
Last. Ibrahim T. OzbolatH-Index: 25
view all 8 authors...
Extrusion-based bioprinting of hydrogels in a granular secondary gel enables the fabrication of cell-laden three-dimensional (3D) constructs in an anatomically accurate manner, which is challenging using conventional extrusion-based bioprinting processes. In this study, carbohydrazide-modified gelatin (Gel-CDH) was synthesized and deposited into a new multi-functional support bath consisting of gelatin microparticles suspended in oxidized alginate (OAlg) solution. During extrusion, Gel-CDH and O...
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#1Bugra Ayan (PSU: Pennsylvania State University)H-Index: 5
#2Dong Nyoung Heo (Kyung Hee University)H-Index: 18
Last. Ibrahim T. OzbolatH-Index: 25
view all 7 authors...
Three-dimensional (3D) bioprinting is an appealing approach for building tissues; however, bioprinting of mini-tissue blocks (i.e., spheroids) with precise control on their positioning in 3D space has been a major obstacle. Here, we unveil “aspiration-assisted bioprinting (AAB),” which enables picking and bioprinting biologics in 3D through harnessing the power of aspiration forces, and when coupled with microvalve bioprinting, it facilitated different biofabrication schemes including scaffold-b...
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#1Dong Nyoung Heo (Kyung Hee University)H-Index: 18
#2Han-Jun Kim (Konkuk University)H-Index: 6
Last. Sun Hee Do (Konkuk University)H-Index: 14
view all 8 authors...
Abstract Articular cartilage exhibits reduced self-healing following degeneration. This research evaluated the effects of hydrogels derived from various polysaccharides—gellan gum (GG), alginate, and agarose—on cartilage regeneration compared with that of hyaluronic acid (HA), which is commonly used in cartilage tissue engineering. Chondrocytes were isolated from the articular cartilage of New Zealand White (NZW) rabbits and stimulated with IL-1β followed by incubation with polysaccharides. The ...
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#1Yeonhee LeeH-Index: 16
#1Yeon-Hee Lee (Kyung Hee University)H-Index: 3
Last. Il Keun KwonH-Index: 38
view all 9 authors...
Exosomes are nanosized vesicles (30–140 nm) of endocytic origin that play important roles in regenerative medicine. They are derived from cell membranes during endocytic internalization and stabilize in biological fluids such as blood and synovia. Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, which, in addition to chronic pain, is characterized by progressive cartilage breakdown, condylar bone remodeling, and synovitis. However, traditional clinical treatments have l...
1 CitationsSource
Abstract Osseointegration is important in osteopenia and osteoporosis patients due to their low bone densities. Gold nanoparticles (GNPs) are greatly beneficial materials as osteogenic agents. The aim of this study is to investigate osseointegration between bones and double layers of GNP-immobilized titanium (Ti) implants. The physicochemical properties of the Ti surface were evaluated by scanning electron microscopy, by atomic force microscopy, by means of the contact angle using water drops, a...
1 CitationsSource
#1Haram Nah (Kyung Hee University)H-Index: 2
#2Dong Hyun Lee (Kyung Hee University)H-Index: 27
Last. Il Keun Kwon (Kyung Hee University)H-Index: 38
view all 12 authors...
ABSTRACTIn an aging society, bone disorders such as osteopenia, osteoporosis, and degenerative arthritis cause serious public health problems. In order to solve these problems, researchers continue...
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#1Kazim K. Moncal (PSU: Pennsylvania State University)H-Index: 6
#2R. Seda Tigli Aydin (Zonguldak Karaelmas University)H-Index: 1
Last. Ibrahim T. OzbolatH-Index: 25
view all 9 authors...
Abstract Differentiation of progenitors in a controlled environment improves the repair of critical-sized calvarial bone defects; however, integrating micro RNA (miRNA) therapy with 3D printed scaffolds still remains a challenge for craniofacial reconstruction. In this study, we aimed to engineer three-dimensional (3D) printed hybrid scaffolds as a new ex situ miR-148b expressing delivery system for osteogenic induction of rat bone marrow stem cells (rBMSCs) in vitro, and also in vivo in critica...
2 CitationsSource
#1Jae Seo Lee (Kyung Hee University)H-Index: 2
#2Sang Jin Lee (Kyung Hee University)H-Index: 17
Last. Il Keun Kwon (Kyung Hee University)H-Index: 38
view all 11 authors...
Abstract Titanium implants (Ti) have been widely used in several medical fields. In clinical practice, Ti can become contaminated with bacteria through a variety of mechanisms. This contamination can lead to implant failure and serious infections. In this study, we aimed to develop a new, hybrid Ti with good biocompatibility and antibacterial properties by immobilizing ceftazidime (CFT) onto the Ti surface through polydopamine (PDA) and polyethyleneimine (PEI) chemistry. Hybrid Ti was confirmed ...
2 CitationsSource
#1Seong Jun KimH-Index: 2
#2Wan-Kyu KoH-Index: 12
Last. Seil SohnH-Index: 10
view all 9 authors...
Abstract Spinal cord injury (SCI) causes permanent nerve damage by disturbing axon regeneration from pro-inflammations and still remains a serious worldwide problem. Ursodeoxycholic acid (UDCA) has been reported that it can serve as an anti-neuroinflammatory drug such as Methylprednisolone (MP). However, the therapeutic effect of UDCA is limited due to its hydrophobic property. In this study, we aimed to investigate the anti-neuroinflammatory effects of gold nanoparticles (GNPs) loading UDCA (GN...
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