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Valentin Borshchevskiy
Moscow Institute of Physics and Technology
64Publications
11H-index
463Citations
Publications 64
Newest
#1Dmitry Bratanov (Forschungszentrum Jülich)H-Index: 2
#2K. KovalevH-Index: 5
Last.Valentin I. GordeliyH-Index: 23
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Recently, two groups of rhodopsin genes were identified in large double-stranded DNA viruses. The structure and function of viral rhodopsins are unknown. We present functional characterization and high-resolution structure of an Organic Lake Phycodnavirus rhodopsin II (OLPVRII) of group 2. It forms a pentamer, with a symmetrical, bottle-like central channel with the narrow vestibule in the cytoplasmic part covered by a ring of 5 arginines, whereas 5 phenylalanines form a hydrophobic barrier in i...
1 CitationsSource
#2Anastasiia GusachH-Index: 1
Last.Vadim CherezovH-Index: 61
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#2Anastasiia GusachH-Index: 1
Last.Vadim CherezovH-Index: 61
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#1Aleksandra Luginina (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
Last.Vadim Cherezov (SC: University of Southern California)H-Index: 61
view all 26 authors...
The G protein–coupled cysteinyl leukotriene receptor CysLT1R mediates inflammatory processes and plays a major role in numerous disorders, including asthma, allergic rhinitis, cardiovascular disease, and cancer. Selective CysLT1R antagonists are widely prescribed as antiasthmatic drugs; however, these drugs demonstrate low effectiveness in some patients and exhibit a variety of side effects. To gain deeper understanding into the functional mechanisms of CysLTRs, we determined the crystal structu...
1 CitationsSource
#1K. KovalevH-Index: 5
#2Dmytro Volkov (Forschungszentrum Jülich)
Last.Valentin I. GordeliyH-Index: 23
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Abstract Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins, heliorhodopsins (HeRs), was recently discovered. In opposite to the known rhodopsins their N-termini face the cytoplasm. HeRs structure and function remain unknown. We present structures of two HeR-48C12 states at 1.5 A showing its remarkable difference from all known rhodopsins. Its internal extracellular part is completely hydrophobic, while the cytoplasmic part comprises a cavity (’active site’), ...
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#1Alexey Mishin (MIPT: Moscow Institute of Physics and Technology)H-Index: 6
#2Anastasiia Gusach (MIPT: Moscow Institute of Physics and Technology)H-Index: 1
Last.Vadim Cherezov (SC: University of Southern California)H-Index: 61
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ABSTRACTIntroduction: X-ray crystallography has made important contributions to modern drug development but its application to many important drug targets has been extremely challenging. The recent...
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