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Muriel Mari
University Medical Center Groningen
VacuoleEndosomeAutophagyBiologyCell biology
58Publications
29H-index
4,778Citations
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Publications 89
Newest
#1Jingyue Jia (UNM: University of New Mexico)H-Index: 5
#2Aurore Claude-Taupin (UNM: University of New Mexico)H-Index: 4
Last. Keith A. Lidke (UNM: University of New Mexico)H-Index: 25
view all 15 authors...
Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a ce...
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#1Jingyue Jia (UNM: University of New Mexico)H-Index: 5
Last. Vojo Deretic (UNM: University of New Mexico)H-Index: 85
view all 15 authors...
Summary Endomembrane damage elicits homeostatic responses including ESCRT-dependent membrane repair and autophagic removal of damaged organelles. Previous studies have suggested that these systems may act separately. Here, we show that galectin-3 (Gal3), a β-galactoside-binding cytosolic lectin, unifies and coordinates ESCRT and autophagy responses to lysosomal damage. Gal3 and its capacity to recognize damage-exposed glycans were required for efficient recruitment of the ESCRT component ALIX du...
1 CitationsSource
#1Alessia Landi (University of Freiburg)H-Index: 1
#2Muriel Mari (UG: University of Groningen)H-Index: 29
Last. Winfried Römer (University of Freiburg)H-Index: 23
view all 13 authors...
Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa, which has developed diverse strategies to impair tissue repair processes and promote infection. Here, we analyse the effect of the P. aeruginosa fucose-binding lectin LecB on human keratinocytes and demonstrate that it trigg...
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#1Antonio Daniel Barbosa (University of Cambridge)H-Index: 9
#2Koini Lim (Medical Research Council)H-Index: 4
Last. Symeon Siniossoglou (University of Cambridge)H-Index: 23
view all 13 authors...
Summary Cells dynamically adjust organelle organization in response to growth and environmental cues. This requires regulation of synthesis of phospholipids, the building blocks of organelle membranes, or remodeling of their fatty-acyl (FA) composition. FAs are also the main components of triacyglycerols (TGs), which enable energy storage in lipid droplets. How cells coordinate FA metabolism with organelle biogenesis during cell growth remains unclear. Here, we show that Lro1, an acyltransferase...
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#1Liangde Zheng (WHU: Wuhan University)H-Index: 1
#2Wen-Jie Shu (WHU: Wuhan University)H-Index: 1
Last. Hai-Ning Du (WHU: Wuhan University)H-Index: 10
view all 14 authors...
ABSTRACTMitophagy is a critical process that safeguards mitochondrial quality control in order to maintain proper cellular homeostasis. Although the mitochondrial-anchored receptor Atg32-mediated c...
1 CitationsSource
#1Martijn R. Molenaar (UU: Utrecht University)H-Index: 6
#2Tsjerk A. Wassenaar (UG: University of Groningen)H-Index: 18
Last. J.B. Helms (UU: Utrecht University)H-Index: 3
view all 15 authors...
Lipid droplets are unique and nearly ubiquitous organelles that store neutral lipids in a hydrophobic core, surrounded by a monolayer of phospholipids. The primary neutral lipids are triacylglycerols and steryl esters. It is not known whether other classes of neutral lipids can form lipid droplets by themselves. Here we show that production of retinyl esters by lecithin:retinol acyl transferase (LRAT) in yeast cells, incapable of producing triacylglycerols and steryl esters, causes the formation...
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#1Yixian Cui (UCSD: University of California, San Diego)H-Index: 2
#2Smriti Parashar (UCSD: University of California, San Diego)H-Index: 2
Last. Susan Ferro-Novick (UCSD: University of California, San Diego)H-Index: 50
view all 12 authors...
INTRODUCTION The unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum (ER) through a variety of mechanisms, including ER-associated degradation (ERAD). ERAD recognizes terminally misfolded or unassembled proteins and retrotranslocates them across the ER membrane into the cytosol, where they are degraded by the proteasome. Certain disease-associated, aggregation-prone proteins, however, cannot be cleared by ERAD and are disposed of by other pathways. Aggregation-pron...
12 CitationsSource
#1Alessia Landi (University of Freiburg)H-Index: 1
#2M. Mari (UG: University of Groningen)
Last. W. Roemer (University of Freiburg)
view all 13 authors...
Abstract Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria employ lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aeruginosa, which has developed diverse strategies to impair tissue repair processes and promote infection. Here, we analyse the effect of the P. aeruginosa fucose-binding lectin LecB on human keratinocytes and demonstrate t...
Source
#1M. Di Rienzo (University of Rome Tor Vergata)H-Index: 3
#2Manuela AntonioliH-Index: 6
Last. Gian Maria Fimia (University of Salento)H-Index: 48
view all 23 authors...
Optimal autophagic activity is crucial to maintain muscle integrity, with either reduced or excessive levels leading to specific myopathies. LGMD2H is a muscle dystrophy caused by mutations in the ubiquitin ligase TRIM32, whose function in muscles remains not fully understood. Here, we show that TRIM32 is required for the induction of muscle autophagy in atrophic conditions using both in vitro and in vivo mouse models. Trim32 inhibition results in a defective autophagy response to muscle atrophy...
5 CitationsSource
#1David M. Hollenstein (University of Vienna)H-Index: 1
#2Rubén Gómez-Sánchez (UMCG: University Medical Center Groningen)H-Index: 14
Last. Claudine Kraft (University of Freiburg)H-Index: 28
view all 9 authors...
Autophagy is initiated by the formation of phagophore assembly sites (PAS), the precursors of autophagosomes. In mammals, PAS form throughout the cytosol in specialized subdomains of the endoplasmic reticulum (ER). In yeast, the PAS is also generated close to the ER, but always in the vicinity of the vacuole. How the PAS is anchored to the vacuole and the functional significance of this localization are unknown. Here, we investigated the role of the PAS-vacuole connection for bulk autophagy in y...
1 CitationsSource
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