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Andrew J. Paterson
University of Alabama at Birmingham
TGF alphaEndocrinologyMolecular biologyBiochemistryBiology
73Publications
33H-index
3,570Citations
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Publications 73
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#1Aditi Dhir (UAB: University of Alabama at Birmingham)
#2Andrew J. Paterson (UAB: University of Alabama at Birmingham)H-Index: 33
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
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#1Shaowei Qiu (UAB: University of Alabama at Birmingham)H-Index: 1
#2Chengcheng Yan (UAB: University of Alabama at Birmingham)
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
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#1Nicholas R. Anderson (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
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#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
#2Sajina Gc (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
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Abstract Human growth hormone (GH) binds and activates GH receptor (GHR) and prolactin (PRL) receptor (PRLR). LNCaP human prostate cancer cells express only GHR. A soluble fragment of IGF-1 receptor (IGF-1R) extracellular domain (sol IGF-1R) interacts with GHR and blocks GH signaling. We now explore sol IGF-1R's specificity for inhibiting GH signaling via GHR vs. PRLR and test GHR and PRLR extracellular domain inhibition determinants. Although T47D human breast cancer cells express GHR and PRLR,...
1 CitationsSource
#1Puneet Agarwal (UAB: University of Alabama at Birmingham)H-Index: 9
#2Stephan Isringhausen (UZH: University of Zurich)H-Index: 3
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
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Summary Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs). TKIs do not eliminate disease-propagating leukemic stem cells (LSCs), suggesting a deeper understanding of niche-dependent regulation of CML LSCs is required to eradicate disease. Cxcl12 is expressed in bone marrow niches and controls HSC maintenance, and here, we show that...
18 CitationsSource
#1Puneet Agarwal (UAB: University of Alabama at Birmingham)H-Index: 9
#2Stephan Isringhausen (UZH: University of Zurich)H-Index: 3
Last. César Nombela-Arrieta (UZH: University of Zurich)H-Index: 20
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#1Ajay Abraham (UAB: University of Alabama at Birmingham)H-Index: 9
#2Shaowei Qiu (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
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Despite the success of BCR-ABL tyrosine kinase inhibitors (TKIs) in inducing remission and prolonging survival of CML patients, cures remain elusive because of persistence of primitive leukemia stem cells (LSC). We have reported that SIRT1, a NAD+ dependent deacetylase, is overexpressed in CML LSC and contributes to their maintenance and TKI resistance, related at least in part to increased p53 acetylation and transcriptional activity (Li et.al; Cancer Cell 2012). However, these studies using RN...
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#1Shaowei Qiu (UAB: University of Alabama at Birmingham)H-Index: 1
#2Andrew J. Paterson (UAB: University of Alabama at Birmingham)H-Index: 33
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
view all 11 authors...
The FLT3-ITD mutation occurs in 25-30% of AML patients, and is associated with increased relapse rate and poor survival. FLT3 tyrosine kinase inhibitors (TKI) have shown encouraging results, but responses are not sustained in most patients. Therefore there is considerable interest in understanding mechanism contributing to resistance and preservation of FLT3-ITD AML stem cells after TKI treatment. Autophagy is an important cellular response that maintains cell survival under stress. Here we inve...
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#1Puneet Agarwal (UAB: University of Alabama at Birmingham)H-Index: 9
#2Hui Li (UAB: University of Alabama at Birmingham)H-Index: 3
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
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CXCL12 plays a major role in hematopoietic stem cells (HSC) localization to regulatory niches in the bone marrow microenvironment (BMM). Previous studies indicate that CXCL12 deletion from Prx+ mesenchymal stem cells (MSC) reduces murine HSC numbers, and from Tek+ endothelial cells (EC) modestly reduces their repopulating activity. In contrast, CXCL12 deletion from Ocn+ osteoblasts or Osx+ osteoprogenitors does not affect HSC function (Greenbaum et al. Nature. 2013 Mar 14;495(7440):227-30; Ding ...
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#1Ajay Abraham (UAB: University of Alabama at Birmingham)H-Index: 9
#2Puneet Agarwal (UAB: University of Alabama at Birmingham)H-Index: 9
Last. Ravi Bhatia (UAB: University of Alabama at Birmingham)H-Index: 56
view all 6 authors...
![Graphic][1] Despite the success of tyrosine kinase inhibitors (TKIs) in treatment of CML, cures remain elusive, as primitive leukemia stem cells (LSC) are retained in patients achieving remission. Previous studies from our group have suggested that Sirtuin 1 (SIRT1) inhibition may represent a novel approach for elimination of LSCs in chronic phase CML . SIRT1 was shown to be overexpressed in CML LSCs, and SIRT1 inhibition using shRNA or a small molecule SIRT1 inhibitor selectively eliminated C...
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