Ahmad R. Hariri
Duke University
Developmental psychologyPsychologyNeuroscienceAmygdalaBiology
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Publications 368
#1Maxwell L. Elliott (Duke University)H-Index: 5
#2Annchen R. Knodt (Duke University)H-Index: 12
Last. Ahmad R. Hariri (Duke University)H-Index: 74
view all 10 authors...
Identifying brain biomarkers of disease risk is a growing priority in neuroscience. The ability to identify meaningful biomarkers is limited by measurement reliability; unreliable measures are unsu...
#1Peter J. Gianaros (CMU: Carnegie Mellon University)H-Index: 43
#2Thomas E. Kraynak (CMU: Carnegie Mellon University)H-Index: 6
Last. Timothy D. Verstynen (CMU: Carnegie Mellon University)H-Index: 31
view all 9 authors...
This study tested whether brain activity patterns evoked by affective stimuli relate to individual differences in an indicator of preclinical atherosclerosis: carotid artery intima-media thickness (CA-IMT). Adults (aged 30-54 years) completed functional magnetic resonance imaging (fMRI) tasks that involved viewing three sets of affective stimuli. Two sets included facial expressions of emotion, and one set included neutral and unpleasant images from the International Affective Picture System (IA...
#1David A.A. Baranger (WashU: Washington University in St. Louis)H-Index: 8
#2Catherine H. Demers (WashU: Washington University in St. Louis)H-Index: 7
Last. Ryan Bogdan (WashU: Washington University in St. Louis)H-Index: 17
view all 14 authors...
ABSTRACT Background Alcohol use has been reliably associated with smaller subcortical and cortical regional gray matter volumes (GMVs). Whether these associations reflect shared predisposing risk factors and/or causal consequences of alcohol use remains poorly understood. Methods Data came from 3 neuroimaging samples (total n=2,423), spanning childhood/adolescence to middle age, with prospective or family-based data. First, we identified replicable GMV correlates of alcohol use. Next, we used fa...
#1Avshalom CaspiH-Index: 150
#1Avshalom CaspiH-Index: 8
Last. Sandhya Ramrakha (University of Otago)H-Index: 18
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Importance: Mental health professionals typically encounter patients at 1 point in patients' lives. This cross-sectional window understandably fosters focus on the current presenting diagnosis. Research programs, treatment protocols, specialist clinics, and specialist journals are oriented to presenting diagnoses, on the assumption that diagnosis informs about causes and prognosis. This study tests an alternative hypothesis: people with mental disorders experience many different kinds of disorde...
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)H-Index: 1
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INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
13 CitationsSource
#1Reut Avinun (Duke University)H-Index: 7
#2Adam Nevo (Duke University)H-Index: 2
Last. Ahmad R. Hariri (Duke University)H-Index: 74
view all 5 authors...
A recent study reported a negative association between a putatively functional dopamine (DA) polygenic score, indexing higher levels of DA signaling, and depressive symptoms. We attempted to replicate this association using data from the Duke Neurogenetics Study. Our replication attempt was made in a subsample of 520 non-Hispanic Caucasian volunteers (277 women, mean age 19.78 ± 1.24 years). The DA polygenic score was based on the following five loci: rs27072 (SLC6A3/DAT1), rs4532 (DRD1), rs1800...
#1Christina O. Carlisi (UCL: University College London)H-Index: 11
#2Terrie E. MoffittH-Index: 161
Last. Ahmad R. Hariri (Duke University)H-Index: 74
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Summary Background Studies with behavioural and neuropsychological tests have supported the developmental taxonomy theory of antisocial behaviour, which specifies abnormal brain development as a fundamental aspect of life-course-persistent antisocial behaviour, but no study has characterised features of brain structure associated with life-course-persistent versus adolescence-limited trajectories, as defined by prospective data. We aimed to determine whether life-course-persistent antisocial beh...
2 CitationsSource
#1David A.A. Baranger (University of Pittsburgh)
#2Lauren R. Few (WashU: Washington University in St. Louis)H-Index: 21
Last. Ryan Bogdan (WashU: Washington University in St. Louis)H-Index: 17
view all 9 authors...
Abstract Background Borderline personality disorder (BPD) is associated with severe psychiatric presentations and has been linked to variability in brain structure. Dimensional models of borderline personality traits (BPT) have grown influential; however, associations between BPT and brain structure remain poorly understood. Methods We tested whether BPT are associated with regional cortical thickness, cortical surface area, and subcortical volumes (n=152 brain structure metrics) in the Duke Neu...
#1Max LamH-Index: 10
#2Chen Chia-Yen (Harvard University)
Last. Laura M. Huckins (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 13
view all 69 authors...
Background: Cognitive traits demonstrate significant genetic correlations with many psychiatric disorders and other health-related traits, and many neuropsychiatric and neurodegenerative disorders are marked by cognitive deficits. Therefore, genome-wide association studies (GWAS) of general cognitive ability might suggest potential targets for nootropic drug repurposing. Our previous effort to identify "druggable genes" (i.e., GWAS-identified genes that produce proteins targeted by known small m...
#1Allison Detloff (UW: University of Wisconsin-Madison)H-Index: 1
#2Ahmad R. Hariri (Duke University)H-Index: 74
Last. Timothy J. Strauman (Duke University)H-Index: 33
view all 3 authors...
Regulatory focus theory (RFT) postulates two cognitive-motivational systems for personal goal pursuit: the promotion system, which is associated with ideal goals (an individual’s hopes, dreams, and aspirations), and the prevention system, which is associated with ought goals (an individual’s duties, responsibilities, and obligations). The two systems have been studied extensively in behavioral research with reference to differences between promotion and prevention goal pursuit as well as the con...