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P. Mohanan
Cochin University of Science and Technology
185Publications
28H-index
2,111Citations
Publications 185
Newest
Published on Jun 27, 2018
Rs Cherian2
Estimated H-index: 2
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S. Syama7
Estimated H-index: 7
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P. Mohanan28
Estimated H-index: 28
Published on Nov 1, 2017in Indian Journal of Medical Research1.25
Madathipat Unnikrishnan , P.R. Umashankar9
Estimated H-index: 9
+ 8 AuthorsP. Mohanan28
Estimated H-index: 28
Background & objectives: Polyethylene terephthalate (PET) graft, designed and developed at our institute for vascular reconstruction, is porous to promote optimal incorporation and neointima formation, requiring pre-clotting or biomodification by sealing the pores before implantation. The objective of this study was to characterize, test and perform preclinical evaluation of hydrogel (alginate dialdehyde cross-linked gelatin) sealed fluoropassivated PET vascular prosthesis in pig model, so as to...
Published on Nov 1, 2017in International Journal of Biological Macromolecules4.78
Neethu Mohan11
Estimated H-index: 11
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P. Mohanan28
Estimated H-index: 28
+ 1 AuthorsD NairPrabha21
Estimated H-index: 21
Abstract The current study investigates the potential of chitosan-hyaluronic acid dialdehyde hydrogels for in vivo cartilage regeneration following two different approaches: Gel alone for cartilage regeneration or combination of chondrocytes and gel for cartilage repair. Critical size osteochondral defects were created in knee joints of Newzealand White rabbits. Allogenic rabbit chondrocytes were encapsulated in hydrogels and gel or gel + cells were implanted in defects aseptically. The regenera...
Published on Sep 25, 2017in Current Drug Metabolism2.28
Veliyath Gopi Reshma1
Estimated H-index: 1
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S. Syama7
Estimated H-index: 7
+ 3 AuthorsP. Mohanan28
Estimated H-index: 28
Published on Jul 1, 2017in Materials Science and Engineering: C4.96
N.S. Remya4
Estimated H-index: 4
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S. Syama7
Estimated H-index: 7
+ 1 AuthorsP. Mohanan28
Estimated H-index: 28
Abstract Although the toxicity/biocompatibility of hydroxyapatite nanoparticles (nano HA), a prospective nano biomaterial is extensively studied, its interaction on biological systems following chronic exposure is less exploited. In the present study, Wistar rats were given various concentrations of nano HA in the diet to determine the chronic toxicity and potential carcinogenicity. Altogether 140 rats were used for the study under various administration dosages along with control. The animals w...
Published on Jul 1, 2017in Biomaterials10.27
S. Syama7
Estimated H-index: 7
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Willi Paul20
Estimated H-index: 20
+ 1 AuthorsP. Mohanan28
Estimated H-index: 28
Abstract Graphene, a 2D carbon material has found vast application in biomedical field because of its exciting physico-chemical properties. The large planar sheet like structure helps graphene to act as an effective carrier of drug or biomolecules in enormous amount. However, limited data available on the biocompatibility of graphene upon interaction with the biological system prompts us to evaluate their toxicity in animal model. In this study organ distribution, clearance and toxicity of PEGyl...
Published on Apr 3, 2017
S. Syama7
Estimated H-index: 7
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C P Aby1
Estimated H-index: 1
(Toyo University)
+ 2 AuthorsP. Mohanan28
Estimated H-index: 28
Graphene, with its unique physico-chemical properties, has found widespread biomedical application. It is used as a carrier for drug or gene delivery, photothermal therapy, bioimaging, in antibacterial agents and for the development of biosensors. Besides this, graphene has the scope to be used for wound healing, tissue engineering and regenerative medicine. In the present study, polyethylene-glycol-(PEG)ylated reduced graphene oxide (PrGO) was synthesized, characterized, and its interaction wit...
Published on Feb 3, 2017in Biomedical Materials3.44
Sony Sandhya1
Estimated H-index: 1
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P. Mohanan28
Estimated H-index: 28
+ 2 AuthorsManoj Komath8
Estimated H-index: 8
A new bioactive calcium sulfate-based formulation (named 'BioCaS') has been developed for bone filler applications. This is a self-setting injectable cement where the preset form comprises bassanite obtained from the uniform submicron-sized precursor crystals of gypsum, modified with hydrogen orthophosphate ions. The results of the safety and efficacy evaluation of BioCaS cement, done as per the International Standards and guidelines, are presented in this paper. The study plan consisted of in v...
Published on Dec 1, 2016in Biointerphases2.01
Sheeja Liza Easo3
Estimated H-index: 3
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P. Mohanan28
Estimated H-index: 28
Iron oxide nanoparticles present an attractive choice for carcinogenic cell destruction via hyperthermia treatment due to its small size and magnetic susceptibility. Dextran stabilized iron oxide nanoparticles (DIONPs) synthesized and characterized for this purpose were used to evaluate its effect on cellular uptake, cytotoxicity, and oxidative stress response in human peripheral blood lymphocytes. In the absence of efficient internalization and perceptible apoptosis, DIONPs were still capable o...
Published on Nov 10, 2016in Current Medicinal Chemistry3.89
Sudhakaran Sruthi2
Estimated H-index: 2
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P. Mohanan28
Estimated H-index: 28
Zinc oxide nanoparticles (ZnO NPs) are one of the widely used nanoparticles with spectrum of application, in the areas like daily care products, sensors, antibacterial agents, and biomedical sector. With extensive application the risk of exposure at occupational and consumer level also increases. Huge amount of data are available on the biointeraction of ZnO NPs. Though the toxicity of ZnO NPs is attributed to particle dissolution inside the cellular compartments and their ability to generate th...
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