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Guilherme L. Sassaki
Federal University of Paraná
PolysaccharideOrganic chemistryChemistryBiochemistryBiology
202Publications
36H-index
4,169Citations
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Publications 202
Newest
#1Andressa Flores (UFPR: Federal University of Paraná)
#2Elberth M. Schiefer (UFPR: Federal University of Paraná)H-Index: 1
Last. Wesley Souza (UFPR: Federal University of Paraná)H-Index: 3
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#1Jefferson da Silva Barbosa (UFRN: Federal University of Rio Grande do Norte)H-Index: 1
#2Diego Araujo Sabry (UFRN: Federal University of Rio Grande do Norte)H-Index: 8
Last. Hugo Alexandre Oliveira Rocha (UFRN: Federal University of Rio Grande do Norte)H-Index: 27
view all 7 authors...
Sulfated polysaccharides (SPs) obtained from green seaweeds are structurally heterogeneous molecules with multifunctional bioactivities. In this work, two sulfated and pyruvated galactans were purified from Caulerpa cupressoides var. flabellata (named SP1 and SP2), and their immunostimulatory effect was evaluated using cultured murine macrophage cells. Both SPs equally increased the production of nitric oxide, reactive oxygen species, and the proinflammatory cytokines TNF-α and IL-6. NMR spectro...
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#1Gabriel Azevedo de Brito Damasceno (UFRN: Federal University of Rio Grande do Norte)H-Index: 2
#2Stella Maria Andrade Gomes Barreto (UFRN: Federal University of Rio Grande do Norte)H-Index: 2
Last. Márcio Ferrari (UFRN: Federal University of Rio Grande do Norte)H-Index: 7
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Abstract Prosopis juliflora is an invasive plant distributed throughout the world and presents metabolites of interest for cosmetology. The aim of this work was to develop a new polysaccharide-based ingredient from P. juliflora and analyze its application in a solid core formulation that upon contact with water instantly forms a gel to improve moisturizing and anti-aging skin properties. Purified extracts by gel chromatography were characterized by NMR and LC-DAD-MS-MS. The in vitro and in vivo ...
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Unravelling new environmentally friendly antifouling (AF) agents is one of the major quests currently facing marine biotechnology. Marine macroalgae represent a rich source of new compounds with promising biological properties, including AF activity, but most of the macroalgal compounds studied to date are terpenoids or polyphenolics. The aim of this work was to investigate the possible AF role played by a usually neglected class of marine natural products: glycolipids (monogalactosyldiacylglyce...
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#1Andressa Amado Martin (UFPR: Federal University of Paraná)H-Index: 2
#2Guilherme L. Sassaki (UFPR: Federal University of Paraná)H-Index: 36
Last. Maria Rita Sierakowski (UFPR: Federal University of Paraná)H-Index: 25
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Abstract Hyaluronic acid (HA) and galactomannans (such as guar gum - GG and locust bean gum - LBG) are biomacromolecules with various applications due to their physicochemical characteristics in solution, especially their ability to form films or hydrogels in some conditions. Some of these applications are possible because they are nontoxic and biocompatible. Mixtures of HA and GG or LBG, at pH 7.4, were prepared at 25 g·L−1 of HA:LBG or HA:GG with percentages of 50:50, 60:40, 70:30 and 80:20 (w...
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#1Thaisa Carvalho Volpe Balbinoti (UFPR: Federal University of Paraná)H-Index: 3
#2Ana Paula Stafussa (UFPR: Federal University of Paraná)H-Index: 4
Last. Regina Maria Matos Jorge (UFPR: Federal University of Paraná)H-Index: 10
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#2Diego Araujo SabryH-Index: 8
Last. Leandro Silva CostaH-Index: 14
view all 5 authors...
A novel derivative of dextran, dextran–gallic acid (Dex–Gal), obtained from simple conjugation with gallic acid, was synthesized by an efficient free radical-mediated method. To verify the synthesis of Dex–Gal, 1H-nuclear magnetic resonance (1H-NMR), Fourier transform infrared (FTIR) spectrometry, and high-performance size-exclusion chromatography (HPSEC) were employed. The results revealed the conjugation of gallic acid with the 15.5 kDa dextran from Leuconostoc mesenteroides. Dex–Gal had a mol...
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#1Aline MendesH-Index: 11
Last. Helena B. NaderH-Index: 48
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Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated chondroitin sulfate (OSCS) were observed in preparations of pharmaceutical porcine heparin, which led to the death of patients, causing a global public health crisis. However, it has not been clarified whether OSCS has been added to the purified hepar...
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#1Marília Locatelli Corrêa-Ferreira (UFPR: Federal University of Paraná)H-Index: 4
Last. Carmen Lúcia de Oliveira Petkowicz (UFPR: Federal University of Paraná)H-Index: 20
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Abstract Artemisia annua is cultivated mainly for isolation of artemisinin, a potent antimalarial compound. Moderate salt stress has been proved to increase the artemisinin synthesis by the plant. The aim of this study was to evaluate the influence of salt stress on physiological parameters and cell wall polysaccharides of A. annua. Plants subjected to salt stress displayed reduction in the biomass and length and showed high damage of cellular membranes. Cell wall polysaccharides extracted from ...
1 CitationsSource
#1Diego Araujo Sabry (UFRN: Federal University of Rio Grande do Norte)H-Index: 8
#2Sara Lima CordeiroH-Index: 11
Last. Hugo Alexandre Oliveira Rocha (UFRN: Federal University of Rio Grande do Norte)H-Index: 27
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Abstract Two sulfated polysaccharides (SPs), F2 and F3, isolated from Codium isthmocladum were found to contain galactose, sulfate, and pyruvate. The apparent molecular weights of F2 and F3 were determined to be 62 and 61 kDa, respectively. NMR spectroscopy combined with chemical analysis showed that F2 and F3 have the same structural features. However, F3 showed higher sulfate/sugar ratio (1/2.6) than F2 (1/4). F2 and F3 are essentially (1→3)-β-D-galactans with some branching at C6. Pyruvylatio...
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