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Fabiola Sesti
National and Kapodistrian University of Athens
3Publications
2H-index
85Citations
Publications 3
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#1Eirini-Stavroula Komseli (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Fabiola Sesti (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
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The maintenance of biomolecules functionality is essential for the assurance of cellular homeostasis. At the proteome level this is achieved by the action of a modular, yet integrated subcellular compartment-specific system which ensures proteome quality control and it is called the proteostasis network (PN). PN is orchestrated by a plethora of different mechanisms and complex protein machines aiming to respond to stressors, recognize and either rescue (via the action of chaperones) or degrade u...
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#1Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
#2Fabiola Sesti (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 12
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Abstract Organisms are constantly challenged by stressors and thus the maintenance of biomolecules functionality is essential for the assurance of cellular homeostasis. Proteins carry out the vast majority of cellular functions by mostly participating in multimeric protein assemblies that operate as protein machines. Cells have evolved a complex proteome quality control network for the rescue, when possible, or the degradation of damaged polypeptides. Nevertheless, despite these proteostasis ens...
34 CitationsSource
At the cellular level, free radicals are tightly controlled by an inducible antioxidant program, since at low non-hazardous amounts they contribute to physiological signalling and homeostasis. However, high levels of oxidative stress promote the accumulation of damaged biomolecules, the impairment of cell signalling pathways and the increase of oncogenic hits. As the intracellular and extracellular levels of oxidative stress increase during ageing or in various diseases, so does the amount of da...
51 Citations
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