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Patrick Mathieu
Laval University
361Publications
48H-index
8,468Citations
Publications 360
Newest
#1Mickael Rosa (Laval University)H-Index: 2
#2Arnaud Chignon (Laval University)
Last.Patrick Mathieu (Laval University)H-Index: 48
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Growing evidence suggests that inflammation is a significant contributor to different cardiovascular diseases (CVDs). Mendelian randomization (MR) was performed to assess the causal inference between plasma soluble IL6 receptor (sIL6R), a negative regulator of IL6 signaling, and different cardiovascular and immune-related disorders. Cis-MR with multiple instrumental variables showed an inverse association of sIL6R with rheumatoid arthritis, atrial fibrillation, stroke, coronary artery disease, a...
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#1Dimitri ArangalageH-Index: 5
#2T S Simon (French Institute of Health and Medical Research)
Last.J. Laschet (French Institute of Health and Medical Research)H-Index: 1
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#1Nicolas PerrotH-Index: 3
#2Donato MoschettaH-Index: 2
Last.Benoit J. ArsenaultH-Index: 30
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#1Sébastien Thériault (Laval University)H-Index: 12
#2Christian Dina (University of Nantes)H-Index: 15
Last.Jean-Jacques Schott (University of Nantes)H-Index: 43
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Background: Calcific aortic valve stenosis (CAVS) is a frequent and life-threatening cardiovascular disease for which there is currently no medical treatment available. To date, only 2 genes, LPA a...
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#1Nicolas PerrotH-Index: 3
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#1Nicolas Perrot (Laval University)H-Index: 3
#2Sébastien Thériault (Laval University)H-Index: 12
Last.Benoit J. Arsenault (Laval University)H-Index: 30
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Importance Genetic variants at theLPAlocus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. Objective To study the associations ofLPAvariants with CAVS in a cohort of patients undergoing heart surgery andLPAwith CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipoprotein...
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#1Deborah Argaud (Laval University)H-Index: 2
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
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#1Audrey-Anne Després (Laval University)
#2Nicolas Perrot (Laval University)H-Index: 3
Last.Benoit J. Arsenault (Laval University)H-Index: 30
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Abstract Background Lipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was to estimate the prevalence of elevated Lp(a) and OxPL levels in patients with CAVS and to determine if individuals with elevated Lp(a) but without CAVS have higher aortic valve microca...
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#1Rihab Bouchareb (Laval University)H-Index: 11
#2Marie-Chloé Boulanger (Laval University)H-Index: 17
Last.Patrick Mathieu (Laval University)H-Index: 48
view all 13 authors...
7 CitationsSource
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