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Patrick Mathieu
Laval University
351Publications
46H-index
8,015Citations
Publications 351
Newest
Published on May 29, 2019in JAMA Cardiology
Nicolas Perrot2
Estimated H-index: 2
(Laval University),
Sébastien Thériault11
Estimated H-index: 11
(Laval University)
+ 23 AuthorsThierry Le Tourneau31
Estimated H-index: 31
(French Institute of Health and Medical Research)
Importance Genetic variants at the LPA locus are associated with both calcific aortic valve stenosis (CAVS) and coronary artery disease (CAD). Whether these variants are associated with CAVS in patients with CAD vs those without CAD is unknown. Objective To study the associations of LPA variants with CAVS in a cohort of patients undergoing heart surgery and LPA with CAVS in patients with CAD vs those without CAD and to determine whether first-degree relatives of patients with CAVS and high lipop...
Published on Jun 28, 2019in Nucleic Acids Research 11.15
Deborah Argaud2
Estimated H-index: 2
(Laval University),
Marie-Chloé Boulanger17
Estimated H-index: 17
(Laval University)
+ 2 AuthorsPatrick Mathieu46
Estimated H-index: 46
(Laval University)
Published on Apr 1, 2019
Audrey-Anne Després (Laval University), Nicolas Perrot2
Estimated H-index: 2
(Laval University)
+ 20 AuthorsJean Guimond5
Estimated H-index: 5
Abstract Background Lipoprotein(a) (Lp[a]) is the preferential lipoprotein carrier of oxidized phospholipids (OxPLs) and a well-established genetic risk factor for calcific aortic valve stenosis (CAVS). Whether Lp(a) predicts aortic valve microcalcification in individuals without CAVS is unknown. Our objective was to estimate the prevalence of elevated Lp(a) and OxPL levels in patients with CAVS and to determine if individuals with elevated Lp(a) but without CAVS have higher aortic valve microca...
Published on May 1, 2019in European Heart Journal 23.24
Rihab Bouchareb11
Estimated H-index: 11
(Laval University),
Marie-Chloé Boulanger17
Estimated H-index: 17
(Laval University)
+ 10 AuthorsPhilippe Pibarot74
Estimated H-index: 74
(Laval University)
Published on Apr 29, 2019in bioRxiv
Benoit J. Arsenault34
Estimated H-index: 34
(Laval University),
William Pelletier (Laval University)+ 10 AuthorsErik S.G. Stroes69
Estimated H-index: 69
(UvA: University of Amsterdam)
BackgroundElevated Lipoprotein(a) (Lp[a]) levels are associated with a broad range of atherosclerotic cardiovascular diseases (CVD). The impact of high Lp(a) levels on human longevity is however controversial. Our objectives were to determine whether genetically-determined Lp(a) levels are associated with parental lifespan and to assess the association between measured and genetically-determined Lp(a) levels and long-term all-cause and cardiovascular mortality.nnMethodsWe determined the associat...
Published on Apr 18, 2019in JCI insight
Kanta Chechi7
Estimated H-index: 7
,
Jinchu Vijay + 5 AuthorsDenis Richard56
Estimated H-index: 56
R. Mickael , Marie-Chloé Boulanger17
Estimated H-index: 17
+ 9 AuthorsSébastien Thériault11
Estimated H-index: 11
Introduction Calcific aortic valve stenosis (CAVS) is the most common heart valve disorder. Genome and transcriptome-wide association studies identified risk variant rs6702619 at the PALMD locus as casually associated with CAVS and with lower PALMD expression. Objective To map and fine-grain molecular analyses to probe the regulation and function of PALMD. Methods Regulation of the PALMD risk locus and its impact on valve interstitial cells (VICs) were evaluated. Reporter assays, DNA-binding ass...
Published on Mar 1, 2019in bioRxiv
Nicolas Perrot2
Estimated H-index: 2
,
Donato Moschetta2
Estimated H-index: 2
+ 18 AuthorsChristian Dina31
Estimated H-index: 31
(University of Nantes)
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition reduces plasma concentrations of low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB) and lipoprotein(a) [Lp(a)]. Atherogenic lipoprotein levels have been linked with calcific aortic valve stenosis (CAVS). Our objectives were to determine the association between variants in PCSK9 and lipoprotein-lipid levels, coronary artery disease (CAD) and CAVS, and to evaluate if PCSK9 could be implicated in aortic v...
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