Jean S. Fleming
University of Otago
Publications 30
#1Kim Brown (University of Otago)H-Index: 3
#2Kerry Shephard (University of Otago)H-Index: 21
Last.Jean S. Fleming (University of Otago)H-Index: 12
view all 5 authors...
ABSTRACTHigher education institutions are seeking greater community engagement through academic, social and civic activity. In response, researcher attention has turned to impacts on students’ education, and benefits to both university and community partners. This phenomenographic study examines how a diverse group of teachers, researchers and administrators at one New Zealand university conceptualised their involvement in community-engaged learning and teaching. We identified an outcome space w...
8 CitationsSource
#1Gregory J. Crowther (UW: University of Washington)H-Index: 19
#2Tom McFadden (University of Otago)H-Index: 1
Last.Katie Davis (UW: University of Washington)H-Index: 14
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ABSTRACTWe assessed the impact of music videos with science-based lyrics on content knowledge and attitudes in a three-part experimental research study of over 1000 participants (mostly K-12 students). In Study A, 13 of 15 music videos were followed by statistically significant improvements on questions about material covered in the videos, while performance on ‘bonus questions’ not covered by the videos did not improve. Video-specific improvement was observed in both basic knowledge and genuine...
8 CitationsSource
BRCA1 mutation carriers have an increased lifetime risk of serous epithelial ovarian cancer (EOC), as well as breast cancer, but reasons for this increased risk remain elusive. We hypothesized that the reported relationship between cytochrome P450 aromatase (CYP19a1) and BRCA1 expression might be used to elucidate this pathway to EOC in women with BRCA1 mutations. Expression of BRCA1, CYP19a1 and steroid receptors was measured by qRT-PCR and immunoblotting in immortalized cell lines from the ova...
#1Olivier J. Becherel (UQ: University of Queensland)H-Index: 18
#2Abrey J. Yeo (UQ: University of Queensland)H-Index: 7
Last.Martin F. Lavin (UQ: University of Queensland)H-Index: 69
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Senataxin, mutated in the human genetic disorder ataxia with oculomotor apraxia type 2 (AOA2), plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA damage response. We demonstrate that senataxin is essential for spermatogenesis and that it functions at two stages in meiosis during crossing-over in homologous recombination and in meiotic sex chromosome inactivation (MSCI). Disruption of the Setx gene caused persistence of DNA doubl...
67 CitationsSource
#1Neil A. Youngson (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 16
#2Nicola Vickaryous (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
Last.Emma Whitelaw (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 37
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An N-ethyl-N-nitrosourea random mutation screen was used to identify recessive modifiers of gene silencing in the mouse using an epigenetically sensitive reporter transgene. One of the mutant lines, MommeR1, was identified as a suppressor of variegation and it showed female-specific age-associated infertility in homozygotes. Linkage analysis identified a region on chromosome 10, containing the Foxo3a gene, previously shown to play a critical role in female gametogenesis. Foxo3a is a transcriptio...
20 CitationsSource
#1Jean S. FlemingH-Index: 12
#2Rosemary GibsonH-Index: 6
Last.Philippa H. GanderH-Index: 31
view all 9 authors...
#1Jean S. Fleming (University of Otago)H-Index: 12
#2H. James McQuillanH-Index: 8
Last.Grant C SellarH-Index: 1
view all 4 authors...
Opioid binding protein/cell adhesion molecule-like gene (OPCML) is frequently inactivated in epithelial ovarian cancer, but the role of this membrane protein in normal reproductive function is unclear. The ovarian surface epithelium (OSE) is thought to be the cell of origin of most epithelial ovarian cancers, some of which arise after transformation of OSE cells lining ovarian inclusion cysts, formed during ovulation. We used immunohistochemistry immunoblotting and quantitative RT-PCR (qRT-PCR) ...
1 CitationsSource
#1Jean S. FlemingH-Index: 12
#1Robin M. McDonaldH-Index: 4
#2John F. SmithH-Index: 8
Last.N.R. CoxH-Index: 1
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Human male fertility is in decline and one reason given for this is the increased incidence of sperm showing chromosomal or DNA damage. Previous work in laboratory and farm animals as well as humans has shown that elevated testicular temperatures increases the incidence of sperm with DNA damage. As part of a study into the effect of temperature on mutation rate in spermatozoa using rams as a model, measurements of sperm DNA damage were also recorded. Twelve mature Dorset x Romney rams, were trai...
1 Citations