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Fang-Cheng Yeh
University of Pittsburgh
77Publications
23H-index
2,122Citations
Publications 77
Newest
Published on Aug 1, 2018in Pediatrics and Neonatology 1.50
Hsiao Lan Sharon Wang1
Estimated H-index: 1
(NTNU: National Taiwan Normal University),
Hsiao-Lan Sharon Wang (NTNU: National Taiwan Normal University)+ 0 AuthorsFang-Cheng Yeh (University of Pittsburgh)
Background Lexical tone identification has a unique role in the perceptual processes of Chinese readers. Reduced lexical tone awareness, along with poor word-decoding abilities, is frequently observed in Chinese-speaking children with developmental dyslexia. However, whether this deficit is linked to reduced auditory processing and interrupted structural connectivity in the brain requires further investigation. This study therefore explores the white matter pathways associated with Chinese chara...
Published on May 1, 2019in Magnetic Resonance Imaging 2.11
Kurt G. Schilling7
Estimated H-index: 7
(Vandy: Vanderbilt University),
Fang-Cheng Yeh1
Estimated H-index: 1
(University of Pittsburgh)
+ 5 AuthorsBennett A. Landman28
Estimated H-index: 28
(Vandy: Vanderbilt University)
Abstract Purpose The diffusion MRI “b-vector” table describing the diffusion sensitization direction can be flipped and permuted in dimension due to different orientation conventions used in scanners and incorrect or improperly utilized file formats. This can lead to incorrect fiber orientation estimates and subsequent tractography failure. Here, we present an automated quality control procedure to detect when the b-table is flipped and/or permuted incorrectly. Methods We define a “fiber coheren...
Sandip S. Panesar4
Estimated H-index: 4
(Stanford University),
Rhett N. D'Souza (University of Pittsburgh)+ -3 AuthorsJuan C. Fernandez-Miranda33
Estimated H-index: 33
(Stanford University)
Background Machine learning (ML) is the application of specialized algorithms to datasets for trend delineation, categorization, or prediction. ML techniques have been traditionally applied to large, highly dimensional databases. Gliomas are a heterogeneous group of primary brain tumors, traditionally graded using histopathologic features. Recently, the World Health Organization proposed a novel grading system for gliomas incorporating molecular characteristics. We aimed to study whether ML coul...
Published on Mar 12, 2019in bioRxiv
Fang-Cheng Yeh23
Estimated H-index: 23
(University of Pittsburgh),
Islam Zaydan1
Estimated H-index: 1
(University of Pittsburgh)
+ 4 AuthorsJessica Barrios-Martinez (University of Pittsburgh)
Diffusion MRI tractography has been used to map the axonal structure of human brain, but its ability to detect neurodegeneration is yet to be explored. Here we report differential tractography, a new type of tractography that utilizes a novel tracking strategy to map the exact segment of fiber pathways with neurodegeneration. It utilizes voxel-wise differences from repeat scans and aggregates them as track-based biomarkers for neurodegeneration. We examined differential tractography on multiple ...
Published on Mar 1, 2019in Brain Structure & Function 3.62
Sandip S. Panesar4
Estimated H-index: 4
(Stanford University),
Joao Tiago A. Belo (University of Pittsburgh)+ 1 AuthorsJuan C. Fernandez-Miranda33
Estimated H-index: 33
(Stanford University)
We previously proposed a bipartite ‘dorsal–ventral’ model of human arcuate fasciculus (AF) morphology. This model does not, however, account for the ‘vertical,’ temporo-parietal subdivision of the AF described in earlier dissection and tractographic studies. In an effort to address the absence of the vertical AF (VAF) within ‘dorsal–ventral’ nomenclature, we conducted a dedicated tractographic and white-matter dissection study of this tract and another short, vertical, posterior-hemispheric fasc...
Published on Jan 1, 2019in Neurotherapeutics 5.55
Sandip S. Panesar4
Estimated H-index: 4
(Stanford University),
Kumar Abhinav8
Estimated H-index: 8
(Stanford University)
+ 3 AuthorsJuan C. Fernandez-Miranda33
Estimated H-index: 33
(Stanford University)
Magnetic resonance imaging tractography permits in vivo visualization of white matter structures. Aside from its academic value, tractography has been proven particularly useful to neurosurgeons for preoperative planning. Preoperative tractography permits both qualitative and quantitative analyses of tumor effects upon surrounding white matter, allowing the surgeon to specifically tailor their operative approach. Despite its benefits, there is controversy pertaining to methodology, implementatio...
Published on Jan 1, 2019in NeuroImage: Clinical 3.94
Francesco Sammartino9
Estimated H-index: 9
(OSU: Ohio State University),
Fang-Cheng Yeh23
Estimated H-index: 23
(University of Pittsburgh),
Vibhor Krishna11
Estimated H-index: 11
(OSU: Ohio State University)
Abstract Objective Focused ultrasound thalamotomy is an emerging treatment for essential tremor, and it is ideal for studying reorganization in the human brain after acute injury because it creates a controlled thalamic ablation without breaching the cortex. However, there is not yet a metric capable of detecting microstructural changes in the presence of acute phase edema with good sensitivity in the chronic phase, when the lesion boundaries become inconspicuous. Methods We prospectively studie...
Published on Jan 1, 2019in Neurotherapeutics 5.55
Fang-Cheng Yeh23
Estimated H-index: 23
(University of Pittsburgh),
Sandip S. Panesar4
Estimated H-index: 4
(University of Pittsburgh)
+ 4 AuthorsJuan C. Fernandez-Miranda33
Estimated H-index: 33
(Stanford University)
Diffusion MRI fiber tracking provides a non-invasive method for mapping the trajectories of human brain connections, but its false connection problem has been a major challenge. This study introduces topology-informed pruning (TIP), a method that automatically identifies singular tracts and eliminates them to improve the tracking accuracy. The accuracy of the tractography with and without TIP was evaluated by a team of 6 neuroanatomists in a blinded setting to examine whether TIP could improve t...
Published on Jan 1, 2019in NeuroImage 5.81
Andreas Horn15
Estimated H-index: 15
(Charité),
Ningfei Li4
Estimated H-index: 4
(Charité)
+ 16 AuthorsWolf-Julian Neumann11
Estimated H-index: 11
(Charité)
Abstract Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders and a growing number of other indications are investigated in clinical trials. To ensure optimal treatment outcome, exact electrode placement is required. Moreover, to analyze the relationship between electrode location and clinical results, a precise reconstruction of electrode placement is required, posing specific challenges to the field of neuroimaging. Since 2014 the open source toolbox Lea...
Published on Sep 1, 2018in NeuroImage 5.81
Fang-Cheng Yeh23
Estimated H-index: 23
(University of Pittsburgh),
Sandip S. Panesar4
Estimated H-index: 4
(University of Pittsburgh)
+ 5 AuthorsTimothy D. Verstynen29
Estimated H-index: 29
(CMU: Carnegie Mellon University)
Abstract A comprehensive map of the structural connectome in the human brain has been a coveted resource for understanding macroscopic brain networks. Here we report an expert-vetted, population-averaged atlas of the structural connectome derived from diffusion MRI data (N = 842). This was achieved by creating a high-resolution template of diffusion patterns averaged across individual subjects and using tractography to generate 550,000 trajectories of representative white matter fascicles annota...
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