Thomas U. Ahearn
National Institutes of Health
CancerOncologyProstate cancerBreast cancerMedicine
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Publications 52
#1Emma H. Allott ('QUB': Queen's University Belfast)H-Index: 15
#2Ericka M. Ebot (Harvard University)H-Index: 5
Last. Lorelei A. Mucci (Harvard University)H-Index: 60
view all 20 authors...
Purpose:Statins are associated with lower risk of aggressive prostate cancer, but lethal prostate cancer is understudied and contributing mechanisms unclear. We prospectively examined statins and lethal prostate cancer risk in the Health Professionals Follow-up Study (HPFS), tested associations with molecular subtypes, and integrated gene expression profiling to identify putative mechanisms. Experimental Design:Our study included 44,126 men cancer-free in 1990, followed for prostate cancer incid...
#1Haoyu Zhang (Johns Hopkins University)H-Index: 3
#2Ni Zhao (Johns Hopkins University)H-Index: 1
Last. Nilanjan Chatterjee (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
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Cancers are routinely classified into subtypes according to various features, including histopathological characteristics and molecular markers. Previous genome-wide association studies have reported heterogeneous associations between loci and cancer subtypes. However, it is not evident what is the optimal modeling strategy for handling correlated tumor features, missing data, and increased degrees-of-freedom in the underlying tests of associations. We propose to test for genetic associations us...
3 CitationsSource
#1Dana Hashim (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
#2Amparo G. Gonzalez-Feliciano (Harvard University)H-Index: 3
Last. Rebecca E. Graff (Harvard University)H-Index: 11
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#1Thomas U. AhearnH-Index: 11
#2Andriy DerkachH-Index: 8
Last. Montserrat Garcia-ClosasH-Index: 82
view all 9 authors...
Background : Three breast cancer PRSs comprised of 313 single nucleotide polymorphisms (SNPs) have been developed and validated in women of European ancestry for predicting risk for overall, estrogen receptor-positive (ER+), and ER-negative (ER-) disease[1]. We evaluated the associations of these PRSs with breast cancer risk in Ghanaian women Methods: Analyses included 899 cases (296 ER+, 277 ER-, and 326 unknown ER status) diagnosed with invasive (n=888) or in situ (n=11) breast cancer and 1,63...
Last. Massimo LodaH-Index: 1
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#1Audrey Y. JungH-Index: 5
#2Thomas U. AhearnH-Index: 11
Last. Jenny Chang-ClaudeH-Index: 92
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#1Claire H. Pernar (Harvard University)H-Index: 4
#2Ericka M. Ebot (Harvard University)H-Index: 5
Last. Lorelei A. Mucci (Harvard University)H-Index: 60
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Abstract Background Growing evidence shows that clinical and molecular subtypes of prostate cancer (PCa) have specific risk factors. Observational studies suggest that physical activity may lower the risk of aggressive PCa. To our knowledge, the association between physical activity and PCa defined by TMPRSS2:ERG has not been evaluated. Objective To prospectively examine the association between physical activity and risk of PCa defined by clinical features and TMPRSS2:ERG. Design, setting, and p...
3 CitationsSource
#2Amber N. WilcoxH-Index: 3
Last. Nilanjan ChatterjeeH-Index: 74
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#1Thomas U. Ahearn (Harvard University)H-Index: 11
#2Sam Peisch (Harvard University)H-Index: 3
Last. Lorelei A. Mucci (Harvard University)H-Index: 60
view all 23 authors...
1 CitationsSource
#1Lauren E. Barber (BU: Boston University)H-Index: 1
#2Travis Gerke (Harvard University)H-Index: 10
Last. Lorelei A. Mucci (Harvard University)H-Index: 60
view all 9 authors...
Purpose: Breast and prostate cancer co-occur in families, and women with a family history of prostate cancer are at increased breast cancer risk. Prostate cancer is among the most heritable cancers, but few studies have investigated its association with familial breast cancer. The objective of this study is to investigate the extent to which familial breast or prostate cancer in first-degree relatives increases prostate cancer risk. Experimental Design: A prospective study of 37,002 U.S. men in ...
5 CitationsSource