Thomas U. Ahearn
National Institutes of Health
Publications 58
#1Haoyu Zhang (Johns Hopkins University)H-Index: 2
#2Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 11
Last.Manjeet K. Bolla (University of Cambridge)H-Index: 27
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Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype. To identify novel loci, we performed a genome-wide association study (GWAS) including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer) of European ancestry, using both standard and novel methodologies that account for underlying tumor heterogeneity by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth fac...
#1Thomas U. Ahearn (NIH: National Institutes of Health)H-Index: 11
#2Haoyu Zhang (Johns Hopkins University)H-Index: 2
Last.Irene L. Andrulis (Lunenfeld-Tanenbaum Research Institute)
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Background: Genome-wide association studies have identified over 170 common breast cancer susceptibility loci, many of them with differential associations by estrogen receptor (ER). How these variants are related to other tumor features is unclear. Methods: Analyses included 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 178 genotyped or imputed single nucleotide polymorphisms (SNPs). We used two-stage polytomous logistic regression models to evaluate ...
#1Dana Hashim (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 6
#2Amparo G. Gonzalez-Feliciano (Harvard University)H-Index: 2
Last.Edward Giovannucci (Harvard University)H-Index: 175
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#1Thomas U. AhearnH-Index: 11
#2Andriy DerkachH-Index: 5
Last.Montserrat Garcia-ClosasH-Index: 79
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Background : Three breast cancer PRSs comprised of 313 single nucleotide polymorphisms (SNPs) have been developed and validated in women of European ancestry for predicting risk for overall, estrogen receptor-positive (ER+), and ER-negative (ER-) disease[1]. We evaluated the associations of these PRSs with breast cancer risk in Ghanaian women Methods: Analyses included 899 cases (296 ER+, 277 ER-, and 326 unknown ER status) diagnosed with invasive (n=888) or in situ (n=11) breast cancer and 1,63...
#1Claire H. Pernar (Harvard University)H-Index: 3
#2Ericka M. Ebot (Harvard University)H-Index: 4
Last.Konrad H. Stopsack (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 7
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Abstract Background Growing evidence shows that clinical and molecular subtypes of prostate cancer (PCa) have specific risk factors. Observational studies suggest that physical activity may lower the risk of aggressive PCa. To our knowledge, the association between physical activity and PCa defined by TMPRSS2:ERG has not been evaluated. Objective To prospectively examine the association between physical activity and risk of PCa defined by clinical features and TMPRSS2:ERG . Design, setting, and ...