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Jessica R. Castle
Oregon Health & Science University
EndocrinologyInsulinType 1 diabetesDiabetes mellitusMedicine
60Publications
18H-index
1,009Citations
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Publications 61
Newest
#1Leah M. Wilson (OHSU: Oregon Health & Science University)H-Index: 2
#2Peter G. Jacobs (OHSU: Oregon Health & Science University)H-Index: 13
Last. Jessica R. Castle (OHSU: Oregon Health & Science University)H-Index: 18
view all 3 authors...
Treatment of type 1 diabetes with exogenous insulin often results in unpredictable daily glucose variability and hypoglycemia, which can be dangerous. Automated insulin delivery systems can improve glucose control while reducing burden for people with diabetes. One approach to improve treatment outcomes is to incorporate the counter-regulatory hormone glucagon into the automated delivery system to help prevent the hypoglycemia that can be induced by the slow pharmacodynamics of insulin action. T...
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#1Melanie A. Jackson (OHSU: Oregon Health & Science University)H-Index: 4
#2Jessica R. Castle (OHSU: Oregon Health & Science University)H-Index: 18
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#1Enoch T. Huang (Legacy Emanuel Medical Center)H-Index: 2
Last. Jessica R. Castle (OHSU: Oregon Health & Science University)H-Index: 18
view all 5 authors...
Background: People with diabetes-related ulcers may benefit from hyperbaric oxygen (HBO2) therapy and from continuous glucose monitoring (CGM). Although blood glucose (BG) meters based o...
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#1Navid Resalat (OHSU: Oregon Health & Science University)H-Index: 5
#2Wade Hilts (OHSU: Oregon Health & Science University)
Last. Peter G. Jacobs (OHSU: Oregon Health & Science University)H-Index: 13
view all 6 authors...
Background:People with type 1 diabetes (T1D) have varying sensitivities to insulin and also varying responses to meals and exercise. We introduce a new adaptive run-to-run model predictive control ...
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#1Leah M. Wilson (OHSU: Oregon Health & Science University)H-Index: 2
#2Nichole S. Tyler (OHSU: Oregon Health & Science University)H-Index: 1
Last. Jessica R. Castle (OHSU: Oregon Health & Science University)H-Index: 18
view all 7 authors...
Background:Decision support smartphone applications integrated with continuous glucose monitors may improve glycemic control in type 1 diabetes (T1D). We conducted a survey to understand trends and...
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#1Ravi Reddy (OHSU: Oregon Health & Science University)H-Index: 6
#2Amanda Wittenberg (OHSU: Oregon Health & Science University)H-Index: 1
Last. Peter G. Jacobs (OHSU: Oregon Health & Science University)H-Index: 13
view all 7 authors...
Abstract Objectives Physical exercise is recommended for individuals with type 1 diabetes, yet the effects of exercise on glycemic control are not well established. We evaluated the impact of different modes of exercise on glycemic control in people with type 1 diabetes. Methods In a 3-week randomized crossover trial, 10 adults with type 1 diabetes (4 men and 6 women, aged 33±6 years; duration of diabetes, 18±10 years; glycated hemoglobin level, 7.4%±1%) were assigned to 3 weeks of intervention:...
4 CitationsSource
#1Navid Resalat (OHSU: Oregon Health & Science University)H-Index: 5
#2Joseph El Youssef (OHSU: Oregon Health & Science University)H-Index: 15
Last. Peter G. Jacobs (OHSU: Oregon Health & Science University)H-Index: 13
view all 5 authors...
Abstract Objective We introduce an adaptive learning algorithm to better adjust postprandial basal and pre-meal bolus insulin for reducing postprandial hypoglycemia in a hybrid artificial pancreas (AP). An AP uses a control algorithm and sensed glucose to automate the delivery of insulin to people with type 1 diabetes (T1D). A hybrid AP requires the person to dose insulin in advance of a meal. Insulin sensitivity is dynamic in people with T1D, making it challenging for an AP to maintain euglycem...
2 CitationsSource
#1Navid Resalat (OHSU: Oregon Health & Science University)H-Index: 5
#2Joseph El YoussefH-Index: 15
Last. Peter G. JacobsH-Index: 13
view all 5 authors...
2 CitationsSource
#2Peter G. JacobsH-Index: 13
Last. Joseph El YoussefH-Index: 15
view all 9 authors...
Introduction: Glycemic control during exercise is challenging for people with type 1 diabetes. Better quantification of insulin dynamics at different exercise intensities and across insulin loading conditions is necessary for accurate insulin dosing during exercise. Methods: Twenty seven participants with type 1 diabetes were evaluated during 3 separate 10-hour fasting aerobic exercise studies with low, medium, and high levels of insulin infusion (100%, 150%, and 300% of basal rate) across two e...
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#1Michael C. RiddellH-Index: 44
#2Zoey LiH-Index: 3
Last. Michael R. RickelsH-Index: 30
view all 14 authors...
Structured exercise can help patients with type 1 diabetes (T1D) achieve physical activity targets, however the effects of exercise type on percent time in range (TIR) and glucose variability are unclear. The Type 1 Diabetes Exercise Initiative Pilot Study provided the opportunity to examine glycemic control on structured exercise days compared to sedentary days. Adults with T1D ([mean ± SD] age= 32 ± 14 years; HbA1C= 7.8 ± 1.6%), using a continuous glucose monitor, were assigned to complete twi...
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