Bhaskar Kallakury
MedStar Georgetown University Hospital
CancerImmunologyCancer researchMedicineBiology
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Publications 209
#1A. KimH-Index: 2
#2G. LynskeyH-Index: 1
Last. E. CohenH-Index: 2
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Last. Pamela L. TumaH-Index: 19
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Recent studies report that the polarity gene myelin and lymphocyte protein 2 (MAL2), is overexpressed in multiple human carcinomas largely at the transcript level. Because chromosome 8q24 amplification (where MAL2 resides) is associated with hepatocellular- and cholangio-carcinomas, we examined MAL2 protein expression in these human carcinoma lesions and adjacent benign tissue using immunohistochemistry. For comparison, we analyzed renal cell carcinomas that are not associated with chromosome 8q...
#1A. Kim (MedStar Georgetown University Hospital)H-Index: 2
#2Joseph H Yacoub (MedStar Georgetown University Hospital)H-Index: 1
Last. Stephan Menne (GUMC: Georgetown University Medical Center)H-Index: 21
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#1Shubhankar Suman (Georgetown University)H-Index: 14
#2Igor Shuryak (Columbia University)H-Index: 19
Last. Kamal Datta (Georgetown University)H-Index: 16
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Abstract Purpose Exposure to ionizing radiation increases risk of breast cancer. Although proton radiation is encountered in outer space and in medicine, we do not fully understand breast cancer risks from protons due to limited in vivo data. The purpose of this study was to comparatively assess the effects of γ-rays and protons on mammary tumorigenesis in APCMin/+ mice. Methods and Materials Female APCMin/+ mice were exposed to 1 GeV protons (1.88 or 4.71 Gy) and 137Cs γ-rays (2 or 5 Gy). Mice ...
#1Jipei Liao (UMB: University of Maryland, Baltimore)H-Index: 7
#2Zejia Yang (UMB: University of Maryland, Baltimore)H-Index: 1
Last. Hancai Dan (UMB: University of Maryland, Baltimore)
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We explored the role of the transcription factor, NF-κB, and its upstream kinase IKKβ in regulation of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma (HNSCC). We showed that cisplatin-resistant HNSCC cells have a stronger ability to migrate and invade, as well as display higher IKKβ/NF-κB activity compared to their parental partners. Importantly, we found that knockdown of IKKβ, but not NF-κB, dramatically impaired cell migration and invasion in ...
#1Mingjun Tan (GUMC: Georgetown University Medical Center)H-Index: 1
#2Rami Mosaoa (KAU: King Abdulaziz University)
Last. Maria Laura Avantaggiati (GUMC: Georgetown University Medical Center)H-Index: 31
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Nonalcoholic fatty liver disease (NAFLD) and its evolution to inflammatory steatohepatitis (NASH) are the most common causes of chronic liver damage and transplantation that are reaching epidemic proportions due to the upraising incidence of metabolic syndrome, obesity, and diabetes. Currently, there is no approved treatment for NASH. The mitochondrial citrate carrier, Slc25a1, has been proposed to play an important role in lipid metabolism, suggesting a potential role for this protein in the pa...
#1Robin D. Tucker (Georgetown University)H-Index: 2
#2Victor Ciofoaia (Georgetown University)
Last. Jill P. Smith (Georgetown University)H-Index: 27
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Background and Aims Nonalcoholic steatohepatitis (NASH) is a common inflammatory liver condition that may lead to cirrhosis and hepatocellular carcinoma (HCC). Risk factors for NASH include a saturated fat diet, altered lipid metabolism, and genetic and epigenetic factors, including microRNAs. Serum levels of cholecystokinin (CCK) are elevated in mice and humans that consume a high-saturated fat diet. CCK receptors (CCK-Rs) have been reported on fibroblasts which when activated can induce fibros...
#1Manasa Suresh (GUMC: Georgetown University Medical Center)H-Index: 3
#2S. Czerwinski (GUMC: Georgetown University Medical Center)H-Index: 1
Last. Stephan Menne (GUMC: Georgetown University Medical Center)H-Index: 21
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Viral and/or host factors that are directly responsible for the acute versus chronic outcome of hepatitis B virus (HBV) infection have not been identified yet. Information on immune response during the early stages of HBV infection in humans is mainly derived from blood samples of patients with acute hepatitis B (AHB), which are usually obtained after the onset of clinical symptoms. Features of intrahepatic immune response in these patients are less studied due to the difficulty of obtaining mul...
#1David S. Goerlitz (Georgetown University)H-Index: 6
#1David Goerlitz (Georgetown University)H-Index: 11
Last. Christopher A. Loffredo (Georgetown University)H-Index: 31
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Liver cancer is associated with genetic mutations caused by environmental exposures, including occupational exposure to alpha radiation emitted by plutonium. We used whole exome sequencing (WES) to characterize somatic mutations in 3 histologically distinct primary liver tumors (angiosarcoma of the liver (ASL), cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC)) from Mayak worker subjects occupationally exposed to ionizing radiation (IR) to investigate the contribution of IR to the muta...
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