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Dennis R. Warner
University of Louisville
58Publications
14H-index
949Citations
Publications 58
Newest
#1Dennis R. WarnerH-Index: 14
#2Jeffrey B. WarnerH-Index: 2
Last.Irina A. KirpichH-Index: 17
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1 CitationsSource
#1Kara H. Zirnheld (University of Louisville)H-Index: 1
#2Dennis R. Warner (University of Louisville)H-Index: 14
Last.Irina A. Kirpich (University of Louisville)H-Index: 17
view all 6 authors...
Abstract Alcoholic liver disease (ALD) comprises a spectrum of liver pathology, including steatosis, steatohepatitis, and cirrhosis. Previous work from our group and others suggests that dietary fat, both the amount and composition, plays a pivotal role in ALD development and progression; however, the impact of specific dietary fatty acids on ALD pathogenesis is not fully elucidated. Preclinical rodent models of ALD revealed the deleterious effects of omega-6 polyunsaturated fatty acids (n-6 PUF...
1 CitationsSource
#1Dennis R. WarnerH-Index: 14
#2Jeffrey B. WarnerH-Index: 2
Last.Irina A. KirpichH-Index: 17
view all 13 authors...
Source
#1Irina A. KirpichH-Index: 17
#2Dennis R. Warner (University of Louisville)H-Index: 14
Last.Kusum K. Kharbanda (UNMC: University of Nebraska Medical Center)H-Index: 28
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Abstract The symposium “Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition” was held at the 19th Congress of International Society for Biomedical Research on Alcoholism on September 13th, 2018 in Kyoto, Japan. The goal of the symposium was to discuss the importance of genetics and nutrition in alcoholic liver disease (ALD) development from mechanistic and therapeutic perspectives. The following is a summary of this session addressing the...
2 CitationsSource
#1Partha Mukhopadhyay (University of Louisville)H-Index: 15
#2Irina A. Smolenkova (University of Louisville)H-Index: 4
Last.Robert M. Greene (University of Louisville)H-Index: 22
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Source
#1Dennis R. Warner (University of Louisville)H-Index: 14
#2Huilin Liu (University of Louisville)H-Index: 3
Last.Irina A. KirpichH-Index: 17
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Alcoholic liver disease (ALD), a significant health problem, progresses through the course of several pathologies including steatosis, steatohepatitis, fibrosis, and cirrhosis. There are no effective FDA-approved medications to prevent or treat any stages of ALD, and the mechanisms involved in ALD pathogenesis are not well understood. Bioactive lipid metabolites play a crucial role in numerous pathological conditions, as well as in the induction and resolution of inflammation. Herein, a hepatic ...
4 CitationsSource
#1Irina A. KirpichH-Index: 17
#2Vatsalya VatsalyaH-Index: 7
Last.Craig J. McClainH-Index: 66
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#1Dennis R. WarnerH-Index: 14
Last.Irina A. KirpichH-Index: 17
view all 5 authors...
Source
#2Dennis R. WarnerH-Index: 14
Last.Irina A. KirpichH-Index: 17
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Source
Background/Objectives Alcohol-induced liver disease (ALD) leads to significant morbidity and mortality and creates an enormous burden on the health care system. There are no effective treatment strategies for any stage of this disease, which range from steatosis, steatohepatitis, fibrosis, to the most severe stage, cirrhosis. Most chronic drinkers will develop early stages of ALD, but only a fraction will proceed to more advanced, life-threatening stages. Therefore, beyond alcohol, other factors...
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