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Justin Carl Cooley
University of Kansas
Oxidative stressThiobarbituric acidMalondialdehydeLipid peroxidationMicrodialysis
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#1Justin Carl Cooley (KU: University of Kansas)H-Index: 1
#2Craig E. Lunte (KU: University of Kansas)H-Index: 39
Oxidative damage is a naturally occurring process where reactive oxygen species (ROS) attack and disrupt normal cellular function, however, these effects become elevated during a stress event, such as ischemia/reperfusion or seizure. One result of oxidative stress is lipid peroxidation, where ROS attack free unsaturated fatty acids forming lipid hydorperoxides, which then breakdown to form secondary products acrolein, 4-hydroxynonenal, and malondialdehyde (MDA) resulting in irreversible membrane...
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