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Victor Faundez
Emory University
101Publications
39H-index
4,262Citations
Publications 101
Newest
Published on Aug 1, 2019in Current Opinion in Cell Biology 8.23
Cortnie Hartwig4
Estimated H-index: 4
(Emory University),
Stephanie A. Zlatic11
Estimated H-index: 11
(Emory University)
+ 3 AuthorsVictor Faundez39
Estimated H-index: 39
(Emory University)
Copper is an essential micronutrient required for oxygen-dependent enzymes, yet excess of the metal is a toxicant. The tug-of-war between these copper activities is balanced by chaperones and membrane transporters, which control copper distribution and availability. The P-type ATPase transporters, ATP7A and ATP7B, regulate cytoplasmic copper by pumping copper out of cells or into the endomembrane system. Mutations in ATP7A and ATP7B cause diseases that share neuropsychiatric phenotypes, which ar...
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Published on Jul 3, 2019in Molecular Biology of the Cell 3.90
Cristy Tower-Gilchrist2
Estimated H-index: 2
(Emory University),
Stephanie A. Zlatic11
Estimated H-index: 11
(Emory University)
+ 5 AuthorsPing Helen Chen44
Estimated H-index: 44
(Emory University)
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Published on Oct 31, 2018in The Journal of Neuroscience 6.07
Bettina Winckler18
Estimated H-index: 18
(University of Virginia Health System),
Victor Faundez39
Estimated H-index: 39
(Emory University)
+ 3 AuthorsHuaye Zhang1
Estimated H-index: 1
(RU: Rutgers University)
How do neurons adapt their endolysosomal system to address the particular challenge of membrane transport across their elaborate cellular landscape and to maintain proteostasis for the lifetime of the organism? Here we review recent findings that address this central question. We discuss the cellular and molecular mechanisms of endolysosomal trafficking and the autophagy pathway in neurons, as well as their role in neuronal development and degeneration. These studies highlight the importance of ...
6 Citations Source Cite
Published on Mar 4, 2019in The Journal of Neuroscience 6.07
Avanti Gokhale13
Estimated H-index: 13
(Emory University),
Cortnie Hartwig4
Estimated H-index: 4
(Emory University)
+ 19 AuthorsAmanda J. Crocker1
Estimated H-index: 1
(Middlebury College)
Neurodevelopmental disorders offer insight into synaptic mechanisms. To unbiasedly uncover these mechanisms, we studied the 22q11.2 syndrome, a recurrent copy number variant, which is the highest schizophrenia genetic risk factor. We quantified the proteomes of 22q11.2 mutant human fibroblasts from both sexes and mouse brains carrying a 22q11.2-like defect, Df(16)A+/- . Molecular ontologies defined mitochondrial compartments and pathways as some of top ranked categories. In particular, we identi...
1 Citations Source Cite
Published on Mar 1, 2018in Developmental Neurobiology 2.60
Cortnie Hartwig4
Estimated H-index: 4
,
William J. Monis2
Estimated H-index: 2
+ 3 AuthorsVictor Faundez39
Estimated H-index: 39
The Biogenesis of Lysosome-related Organelles Complex-1 (BLOC-1) and the BLOC-One-Related Complex (BORC) are cytosolic protein complexes required for specialized membrane protein traffic along the endocytic route and for the spatial distribution of endosome-derived compartments, respectively. BLOC-1 and BORC complex subunits and components of their interactomes have been associated with the risk and/or pathomechanisms of neurodevelopmental disorders. Thus, cellular processes requiring BLOC-1 and...
3 Citations Source Cite
Published on Jan 1, 2018in Cell systems 8.64
Stephanie A. Zlatic11
Estimated H-index: 11
(Emory University),
Alysia Vrailas-Mortimer5
Estimated H-index: 5
(ISU: Illinois State University)
+ 11 AuthorsCortnie Hartwig4
Estimated H-index: 4
(Agnes Scott College)
Summary Rare neurological diseases shed light onto universal neurobiological processes. However, molecular mechanisms connecting genetic defects to their disease phenotypes are elusive. Here, we obtain mechanistic information by comparing proteomes of cells from individuals with rare disorders with proteomes from their disease-free consanguineous relatives. We use triple-SILAC mass spectrometry to quantify proteomes from human pedigrees affected by mutations in ATP7A, which cause Menkes disease,...
6 Citations Source Cite
Published on Oct 2, 2017in Cellular logistics
Gopal P. Sarma1
Estimated H-index: 1
,
Victor Faundez39
Estimated H-index: 39
Integrative biological simulations have a varied and controversial history in the biological sciences. From computational models of organelles, cells, and simple organisms, to physiological models of tissues, organ systems, and ecosystems, a diverse array of biological systems have been the target of large-scale computational modeling efforts. Nonetheless, these research agendas have yet to prove decisively their value among the broader community of theoretical and experimental biologists. In th...
2 Citations Source Cite
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