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Myriam Martin
Lund University
Complement systemNeutrophil extracellular trapsMolecular biologyImmunologyBiology
30Publications
13H-index
751Citations
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Publications 31
Newest
#1Karolina Smolag (Lund University)H-Index: 1
#2Christine M. Mueni (Lund University)
Last. Anna M. Blom (Lund University)H-Index: 54
view all 9 authors...
ABSTRACTMacrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in se...
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#2Myriam MartinH-Index: 13
Last. Eva Norström (Lund University)H-Index: 14
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Background Flow cytometric platelet activation has emerged as an alternative diagnostic test for inherited platelet disorders. It is, however, labor intensive and few studies have directly compared the performance of flow cytometric platelet activation (PACT) to light transmission aggregometry (LTA). The aims of this study were 1/ to develop a simplified flow cytometric platelet activation assay using microtiter plates and 2/ to correlate the outcome to gold standard method LTA, and to clinical ...
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#1Myriam Martin (Lund University)H-Index: 13
#2Karolina I. Smoląg (Lund University)H-Index: 1
Last. Anna M. Blom (Lund University)H-Index: 54
view all 9 authors...
In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). C4d levels were determined by enzyme-linked immunosorbent assay in plasma samples of patients with established SLE using a novel approach based on detection of a short linear cleavage neoepitope. Cross-sectional associations were studied in 98 patients with SLE with samples taken at lower or higher respective disease activity. Temporal associati...
3 CitationsSource
#1Katarina HočevarH-Index: 1
#2Barbara SobotičH-Index: 3
Last. Boris TurkH-Index: 59
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#1Jonatan Leffler (UWA: University of Western Australia)H-Index: 10
#2Zoltán Prohászka (Semmelweis University)H-Index: 39
Last. Anna M. Blom (Lund University)H-Index: 54
view all 12 authors...
Background: Neutrophil extracellular traps (NETs) can stimulate thrombosis, and their degradation is decreased in several autoimmune disorders. It was recently reported that some patients with haemolytic uraemic syndrome (HUS) also fail to degrade NETs and that neutrophils from Shiga toxin-associated HUS are primed to form NETs. Method: We used a well-characterized cohort of 74 thrombotic microangiopathy (TMA) patients, with a subset also providing follow-up samples, and 112 age-matched controls...
10 CitationsSource
#1Myriam Martin (Lund University)H-Index: 13
#2Anna M. Blom (Lund University)H-Index: 54
Recognition and removal of apoptotic and necrotic cells must be efficient and highly controlled to avoid excessive inflammation and autoimmune responses to self. The complement system, a crucial part of innate immunity, plays an important role in this process. Thus, apoptotic and necrotic cells are recognized by complement initiators such as C1q, mannose binding lectin, ficolins, and properdin. This triggers complement activation and opsonization of cells with fragments of C3b, which enhances ph...
42 CitationsSource
#1Myriam Martin (Lund University)H-Index: 13
#2Karolina I. Smoląg (Lund University)H-Index: 1
Last. Anna M. Blom (Lund University)H-Index: 54
view all 10 authors...
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#1Myriam MartinH-Index: 13
#2Jonatan LefflerH-Index: 10
Last. Anna M. BlomH-Index: 54
view all 9 authors...
Factor H (FH) binds apoptotic cells to limit the inflammatory potential of complement. Here we report that FH is actively internalized by apoptotic cells to enhance cathepsin L-mediated cleavage of endogenously expressed C3, which results in increased surface opsonization with iC3b. In addition, internalized FH forms complexes with nucleosomes, facilitates their phagocytosis by monocytes and induces an anti-inflammatory biased cytokine profile. A similar cytokine response was noted for apoptotic...
27 CitationsSource
#1Jonatan Leffler (UWA: University of Western Australia)H-Index: 10
#2Katarzyna Ciacma (Lund University)H-Index: 2
Last. Anna M. Blom (Lund University)H-Index: 54
view all 6 authors...
Introduction Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to degrade NETs. In this study we extend these findings by investigating the ability of p...
23 CitationsSource
#1Jonatan Leffler (Lund University)H-Index: 10
#2Birgitta Gullstrand (Lund University)H-Index: 17
Last. Anna M. Blom (Lund University)H-Index: 54
view all 7 authors...
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