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Aikou Okamoto
Jikei University School of Medicine
176Publications
18H-index
1,432Citations
Publications 176
Newest
#1Koji Matsuo (SC: University of Southern California)H-Index: 22
#2J.C. Cripe (WashU: Washington University in St. Louis)H-Index: 1
Last.Akira Yabuno (Saitama Medical University)H-Index: 4
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Abstract Objective To examine the association between ovarian conservation and oncologic outcome in surgically-treated young women with early-stage, low-grade endometrial cancer. Methods This multicenter retrospective study examined women aged Results During the study period, the ovarian conservation rate significantly increased in the US cohort from 5.4% to 16.4% (P = 0.020) whereas the rate was unchanged in the Japan cohort (6.3–8.7%, P = 0.787). In the US cohort, ovarian conservation was not ...
#1Taizan Kamide (Jikei University School of Medicine)H-Index: 1
#2M. Yamamura (Jikei University School of Medicine)
Last.Aikou Okamoto (Jikei University School of Medicine)H-Index: 18
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#1V Heong (TTSH: Tan Tock Seng Hospital)
#2T.Z. Tan (NUS: National University of Singapore)
Last.J Ng (NUS: National University of Singapore)
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#1Takafumi Kuroda (Jikei University School of Medicine)H-Index: 2
#2Hideaki OgiwaraH-Index: 20
Last.Aikou Okamoto (Jikei University School of Medicine)H-Index: 18
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Abstract Objective Ovarian clear cell carcinoma (OCCC) is often resistant to conventional, standard chemotherapy using cytotoxic drugs. OCCC harbors a unique genomic feature of frequent (approximately 50%) ARID1A deficiency. The present study was performed to investigate standard chemotherapeutic options suitable for ARID1A-deficient OCCC patients. Methods Drugs with selective toxicity to ARID1A-deficient OCCC cells were identified among six cytotoxic drugs used in standard chemotherapy for OCCC...
#1Ken Takahashi (Jikei University School of Medicine)H-Index: 1
#2Ohsuke Migita (St. Marianna University School of Medicine)H-Index: 8
Last.Aikou Okamoto (Jikei University School of Medicine)H-Index: 18
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Background: To avoid hemolytic disease of the fetus and newborn resulting from maternal alloantibodies against fetal Rh antigens, anti-D immunoglobulin is routinely administered to RhD-negative pregnant women in Japan. Fetal RHD genotyping using cell-free DNA may prevent unnecessary antibody administration; however, current PCR-based methods, which detect RHD deletion, do not address the higher rates of RHD-positive D antigen-negative alleles in nonwhite populations without additional inspection...
Abstract Background Data are limited regarding the use of poly(adenosine diphosphate [ADP]–ribose) polymerase inhibitors, such as veliparib, in combination with chemotherapy followed by maintenance...
#1David M. Gershenson (University of Texas MD Anderson Cancer Center)H-Index: 82
#2Aikou Okamoto (Jikei University School of Medicine)H-Index: 18
Last.Isabelle Ray-Coquard (UCBL: Claude Bernard University Lyon 1)H-Index: 44
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#1Akihiro UmezawaH-Index: 52
#2Akihiro Hasegawa (Jikei University School of Medicine)
Last.Aikou Okamoto (Jikei University School of Medicine)H-Index: 18
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Abstract The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine. Endothelial cells are obtained from large arteries and veins in the amniotic membrane as well as the umbilical cord. The amnion-derived cells exhibit transdifferentiation ...
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