Aikou Okamoto
Jikei University School of Medicine
CancerPathologyOvarian cancerMedicineBiology
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Publications 208
#1Carol Aghajanian (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 54
#2Michael A. Bookman (KP: Kaiser Permanente)H-Index: 37
Last. Danielle Sullivan (AbbVie)H-Index: 5
view all 14 authors...
#1Shannon Neville Westin (University of Texas MD Anderson Cancer Center)H-Index: 22
#2Kathleen N. Moore (University of Oklahoma Medical Center)H-Index: 1
Last. Joon Rhee (AstraZeneca)H-Index: 1
view all 11 authors...
#1Shika Hanif Malgundkar (Sultan Qaboos University)
#2Ikram A. Burney (Sultan Qaboos University)H-Index: 10
Last. Yahya Tamimi (Sultan Qaboos University)H-Index: 3
view all 7 authors...
BACKGROUND: The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet its role in epithelial ovarian cancer (EOC) progression. In the present study, we examined the role of FAT4 in proliferation and metastasis, and its mechanisms of interaction in these processes. METHODS: We have performed cell viability, colony formation, and invasion assays in o...
#1Takashi Onda (Kitasato University)H-Index: 24
#2Toyomi Satoh (University of Tsukuba)H-Index: 21
Last. Kimio Ushijima (Kurume University)H-Index: 22
view all 20 authors...
BACKGROUND: Regarding the comparison between primary debulking surgery (PDS) and neoadjuvant chemotherapy (NACT) for stage III/IV ovarian, tubal and peritoneal cancers, EORTC55971 and CHORUS studies demonstrated noninferiority of NACT. Previously, we reported reduced invasiveness of NACT in JCOG0602. This is a final analysis including the primary endpoint of overall survival (OS). METHODS: Patients were randomised to PDS (PDS followed by 8x paclitaxel and carboplatin, i.e. TC regimen) or NACT (4...
1 CitationsSource
#1Motoaki Saito (Jikei University School of Medicine)H-Index: 5
#2Suguru Odajima (Jikei University School of Medicine)
Last. Aikou Okamoto (Jikei University School of Medicine)H-Index: 24
view all 10 authors...
BACKGROUND/AIM: We aimed to analyse the prognosis of patients who underwent primary debulking surgery (PDS) and those who underwent interval debulking surgery (IDS) following four courses of paclitaxel+ carboplatin as preoperative chemotherapy to examine the usefulness of preoperative chemotherapy. PATIENTS AND METHODS: We included 45 patients with epithelial ovarian and peritoneal cancers accompanied with diaphragmatic lesions who underwent standard surgery combined with diaphragmatic surgery a...
#1Taisuke Sato (Jikei University School of Medicine)H-Index: 1
#2Takashi Kojima (Hokkaido University)H-Index: 7
Last. Takahiro Yamada (Kyoto University)H-Index: 21
view all 13 authors...
We present two unrelated Japanese pedigrees with achondrogenesis type 1b (ACG1B), characterized by prenatally lethal fetal hydrops and severe micromelia. The affected members in these pedigrees carried a common homozygous missense point mutation in solute carrier family 26 member 2 (SLC26A2), a gene associated with ACG1B (NM_000112:c.1987G>A). This loss-of-function point mutation causes substitution of glycine 663 with arginine in a highly conserved loop domain of SLC26A2. Interestingly, only a ...
#1David M. Gershenson (University of Texas MD Anderson Cancer Center)H-Index: 81
#2Aikou Okamoto (Jikei University School of Medicine)H-Index: 24
Last. Isabelle Ray-Coquard (UCBL: Claude Bernard University Lyon 1)H-Index: 47
view all 3 authors...
#1Robert L. Hollis (Edin.: University of Edinburgh)H-Index: 3
#2John P. ThomsonH-Index: 18
Last. M. Mackean (NHS Lothian)
view all 15 authors...
Endometrioid ovarian carcinoma (EnOC) is an under-investigated type of ovarian carcinoma. Here, we report the largest genomic study of EnOCs to date, performing whole exome sequencing of 112 cases following rigorous pathological assessment. High frequencies of mutation were detected in CTNNB1(43%), PIK3CA(43%), ARID1A(36%), PTEN(29%), TP53(26%) and SOX8(19%), a novel target of recurrent mutation in EnOC. POLE and mismatch repair protein-encoding genes were mutated at lower frequency (6%, 18%) wi...
#2Kouhei SugimotoH-Index: 3
Last. Nao SuzukiH-Index: 20
view all 10 authors...
PurposeThe oncofertility decision tree was developed by the oncofertility consortium as a tool to support healthcare professionals and patients through the complicated process of deciding the most appropriate fertility preservation strategy for patients with cancer. Various strategies include oocyte retrieval, oocyte donation, use of a gestational carrier and adoption. However, differences in the cultural and legal landscape present serious barriers to utilizing some of these strategies in Japan...
#1Aikou Okamoto (Jikei University School of Medicine)H-Index: 24