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Christopher D. Richardson
University of California, Santa Barbara
59Publications
27H-index
4,073Citations
Publications 59
Newest
Published on May 1, 2019in Scientific Reports4.01
Chen-Jei Tai (TMU: Taipei Medical University), Ching-Hsuan Liu (TMU: Taipei Medical University)+ 4 AuthorsLiang-Tzung Lin (TMU: Taipei Medical University)
Oncolytic virotherapy represents an emerging development in anticancer therapy. Although it has been tested against a variety of cancers, including breast cancer, the efficacy of oncolytic viral vectors delivered as a monotherapy is limited. Enhancing viral oncolytic therapies through combination treatment with anticancer agents is a feasible strategy. In this study, we considered a chemovirotherapeutic approach for treating breast adenocarcinoma using oncolytic measles virus (MV) and the chemot...
Published on Mar 29, 2019in Cells
Alagie Jassey3
Estimated H-index: 3
,
Ching-Hsuan Liu + 3 AuthorsLiang-Tzung Lin2
Estimated H-index: 2
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein, we demonstrated that the HCV non-structural protein 5A (NS5A) plays a key role in regulating cellular mitophagy. Specifically, the expression of HCV NS5A in the hepatoma cells triggered hallmarks of mitophagy including mitochondrial fragmentatio...
Published on Dec 1, 2018in Emerging microbes & infections6.21
Chien Ju Lin , Ching Hsuan Liu (Halifax)+ 4 AuthorsLiang Tzung Lin15
Estimated H-index: 15
(TMU: Taipei Medical University)
Coxsackievirus A16 (CVA16) is an etiologic agent of hand, foot, and mouth disease (HFMD) that affects young children, and although typically self-limited, severe complications, and fatal cases have been reported. Due to the lack of specific medication and vaccines against CVA16, there is currently a need to develop effective antivirals to better control CVA16 infections in epidemic areas. In this study, we identified the tannins chebulagic acid (CHLA) and punicalagin (PUG) as small molecules tha...
Published on Mar 28, 2018in eLife7.55
Nicholas van Buuren9
Estimated H-index: 9
(Stanford University),
Timothy L. Tellinghuisen19
Estimated H-index: 19
(Scripps Research Institute)
+ 1 AuthorsKarla Kirkegaard48
Estimated H-index: 48
(Stanford University)
Viruses are simple organisms that consist of genetic information and a few types of proteins. They cannot replicate on their own, and instead hijack the molecular machinery of a host cell to produce more of themselves. Inside an infected cell, the genetic information of the virus is replicated and ‘read’ to create viral proteins. These components are then assembled to form a new generation of viruses. During this process, genetic errors may occur that lead to modifications in the viral proteins,...
Published on Dec 1, 2017in Journal of Virology4.32
Michael N. Ha1
Estimated H-index: 1
(U of T: University of Toronto),
Sebastien Delpeut5
Estimated H-index: 5
(Dal: Dalhousie University)
+ 7 AuthorsChristopher D. Richardson9
Estimated H-index: 9
(Dal: Dalhousie University)
Published on Oct 1, 2017in Gut17.94
Ching Hsuan Liu3
Estimated H-index: 3
(TMU: Taipei Medical University),
Chun Ching Lin23
Estimated H-index: 23
(KMU: Kaohsiung Medical University)
+ 11 AuthorsJustin Shields4
Estimated H-index: 4
Objective Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome this limitation, we developed highly bioavailable silibinin nanoparticles (SB-NPs) and evaluated their efficiency against HCV infection. Design SB-NPs were prepared using a nanoemu...
Published on May 15, 2017in Journal of Virology4.32
Sebastien Delpeut5
Estimated H-index: 5
(Dal: Dalhousie University),
Gary Sisson17
Estimated H-index: 17
(Dal: Dalhousie University)
+ 1 AuthorsChristopher D. Richardson15
Estimated H-index: 15
(Dal: Dalhousie University)
Published on Sep 20, 2016in Viruses3.81
Liang-Tzung Lin2
Estimated H-index: 2
,
Christopher D. Richardson15
Estimated H-index: 15
(Dal: Dalhousie University)
The hemagglutinin (H) protein of measles virus (MeV) interacts with a cellular receptor which constitutes the initial stage of infection. Binding of H to this host cell receptor subsequently triggers the F protein to activate fusion between virus and host plasma membranes. The search for MeV receptors began with vaccine/laboratory virus strains and evolved to more relevant receptors used by wild-type MeV. Vaccine or laboratory strains of measles virus have been adapted to grow in common cell lin...
Published on Jun 1, 2016in Antiviral Research4.13
Chueh Yao Chung5
Estimated H-index: 5
(KMU: Kaohsiung Medical University),
Ching Hsuan Liu3
Estimated H-index: 3
(TMU: Taipei Medical University)
+ 10 AuthorsChristopher D. Richardson15
Estimated H-index: 15
(Dal: Dalhousie University)
Abstract Without a vaccine, hepatitis C virus (HCV) remains a global medical and socio-economic burden, predisposing about 170 million carriers worldwide to end-stage liver diseases including cirrhosis and hepatocellular carcinoma. Although the recently developed direct-acting antivirals (DAAs) have revolutionized hepatitis C treatment, most of them are unsuitable for monotherapy due to risks of resistance, thus necessitating combination with interferon (IFN)-alpha, ribavirin, or additional DAAs...
Published on Jul 1, 2015in Journal of Hepatology18.95
Liang Tzung Lin15
Estimated H-index: 15
(TMU: Taipei Medical University),
Chueh Yao Chung5
Estimated H-index: 5
(KMU: Kaohsiung Medical University)
+ 10 AuthorsMing Hong Yen5
Estimated H-index: 5
(KMU: Kaohsiung Medical University)
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