Christopher D. Richardson
Dalhousie University
Molecular biologyVirologyVirusMeasles virusBiology
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Publications 96
#1Patrick T. Rudak (UWO: University of Western Ontario)H-Index: 5
#2Tony Yao (UWO: University of Western Ontario)
Last. S. M. Mansour Haeryfar (UWO: University of Western Ontario)H-Index: 22
view all 4 authors...
Measles virus (MeV) binds, infects and kills CD150+ memory T-cells, leading to "immune amnesia". Whether MeV targets innate, memory-like T-cells is unknown. We demonstrate that human peripheral blood and hepatic MAIT and iNKT cells express surprisingly high levels of CD150, more than any other lymphocyte subsets, including central and effector memory T-cells. Furthermore, exposing MAIT cells to MeV results in their efficient infection and rapid apoptosis. This constitutes the first report of dir...
#1Chen-Jei Tai (TMU: Taipei Medical University)
#2Alagie Jassey (TMU: Taipei Medical University)H-Index: 5
Last. Liang-Tzung Lin (TMU: Taipei Medical University)H-Index: 2
view all 7 authors...
Hepatocellular carcinoma (HCC), including hepatitis C virus (HCV)-induced HCC, is a deadly disease highly refractory to chemotherapy, thus requiring the continuous identification of novel treatment strategies. Berberine (BBR) has been previously reported to inhibit hepatoma cell growth, but the main type of cell death elicited by BBR, and whether the alkaloid can inhibit hepatoma cells carrying HCV genomes, is unclear. Herein, we show that BBR treatment induced a biphasic cell death irrespective...
#1Robyn Ralph (Vaccine and Infectious Disease Organization)H-Index: 1
#2Jocelyne Lew (Vaccine and Infectious Disease Organization)H-Index: 2
Last. Mohammed N. Al-AhdalH-Index: 20
view all 15 authors...
On 31 December 2019 the Wuhan Health Commission reported a cluster of atypical pneumonia cases that was linked to a wet market in the city of Wuhan, China. The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. As of 28 January 2020, there are in excess of 4,500 laboratory-confirmed cases, with > 100 known deaths. As with the SARS-CoV, infections in children appear to be rar...
29 CitationsSource
#1Yujia Li (Peking Union Medical College)H-Index: 4
#2Max Xuezhong Ma (U of T: University of Toronto)H-Index: 1
Last. Limin Chen (U of T: University of Toronto)H-Index: 13
view all 8 authors...
Background and Aims. Ubiquitin-specific protease 18 (USP18) is involved in immunoregulation and response to interferon- (IFN-) based treatment in patients chronically infected with hepatitis C virus (HCV). We investigated whether and how its upregulation alters HCV infection. Methods. Overexpression of wild-type (USP18 WT) or catalytically inactive mutant (USP18 C64S) USP18 was examined for effects on HCV replication in the absence and presence of IFNα or IFNλ using both the HCV-infective model ...
1 CitationsSource
#1Chen Jei Tai (TMU: Taipei Medical University)H-Index: 2
#1Chen Jei Tai (TMU: Taipei Medical University)H-Index: 4
Last. Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 20
view all 7 authors...
Oncolytic virotherapy represents an emerging development in anticancer therapy. Although it has been tested against a variety of cancers, including breast cancer, the efficacy of oncolytic viral vectors delivered as a monotherapy is limited. Enhancing viral oncolytic therapies through combination treatment with anticancer agents is a feasible strategy. In this study, we considered a chemovirotherapeutic approach for treating breast adenocarcinoma using oncolytic measles virus (MV) and the chemot...
2 CitationsSource
#1Alagie Jassey (TMU: Taipei Medical University)H-Index: 5
#2Ching-Hsuan Liu (TMU: Taipei Medical University)H-Index: 2
Last. Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 20
view all 6 authors...
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein, we demonstrated that the HCV non-structural protein 5A (NS5A) plays a key role in regulating cellular mitophagy. Specifically, the expression of HCV NS5A in the hepatoma cells triggered hallmarks of mitophagy including mitochondrial fragmentatio...
12 CitationsSource
#1Chien Ju Lin (KMU: Kaohsiung Medical University)H-Index: 2
#2Ching Hsuan Liu (TMU: Taipei Medical University)H-Index: 5
Last. Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 20
view all 7 authors...
AbstractCoxsackievirus A16 (CVA16) is an etiologic agent of hand, foot, and mouth disease (HFMD) that affects young children, and although typically self-limited, severe complications, and fatal ca...
3 CitationsSource
#1Nicholas van Buuren (Stanford University)H-Index: 10
#2Timothy L. Tellinghuisen (Scripps Research Institute)H-Index: 20
Last. Karla Kirkegaard (Stanford University)H-Index: 49
view all 4 authors...
Viruses are simple organisms that consist of genetic information and a few types of proteins. They cannot replicate on their own, and instead hijack the molecular machinery of a host cell to produce more of themselves. Inside an infected cell, the genetic information of the virus is replicated and ‘read’ to create viral proteins. These components are then assembled to form a new generation of viruses. During this process, genetic errors may occur that lead to modifications in the viral proteins,...
2 CitationsSource
#1Nicholas van Buuren (Stanford University)H-Index: 10
#2Timothy L. Tellinghuisen (Scripps Research Institute)H-Index: 20
Last. Karla Kirkegaard (Stanford University)H-Index: 49
view all 4 authors...
#1Michael N. Ha (U of T: University of Toronto)H-Index: 2
#2Sebastien Delpeut (Dal: Dalhousie University)H-Index: 6
Last. Christopher D. Richardson (Dal: Dalhousie University)H-Index: 39
view all 10 authors...
The inhibitors carbobenzoxy (Z)-d-Phe-l-Phe-Gly (fusion inhibitor peptide [FIP]) and 4-nitro-2-phenylacetyl amino-benzamide (AS-48) have similar efficacies in blocking membrane fusion and syncytium formation mediated by measles virus (MeV). Other homologues, such as Z-d-Phe, are less effective but may act through the same mechanism. In an attempt to map the site of action of these inhibitors, we generated mutant viruses that were resistant to the inhibitory effects of Z-d-Phe-l-Phe-Gly. These 10...
8 CitationsSource