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Christopher D. Richardson
University of California, Santa Barbara
59Publications
27H-index
4,073Citations
Publications 59
Newest
Published on Dec 1, 2017in Journal of Virology 4.37
Michael N. Ha1
Estimated H-index: 1
(U of T: University of Toronto),
Sebastien Delpeut5
Estimated H-index: 5
(Dal: Dalhousie University)
+ 7 AuthorsChristopher D. Richardson9
Estimated H-index: 9
(Dal: Dalhousie University)
4 Citations Source Cite
Published on Jan 1, 2013
William J. Bellini61
Estimated H-index: 61
,
George Englund16
Estimated H-index: 16
,
Christopher D. Richardson27
Estimated H-index: 27
Published on Mar 15, 2010in Journal of Virology 4.37
Claudia S. Antunes Ferreira1
Estimated H-index: 1
(Universidade Lusófona),
Marie Frenzke13
Estimated H-index: 13
(Mayo Clinic)
+ 3 AuthorsRoberto Cattaneo66
Estimated H-index: 66
Recent studies of primate models suggest that wild-type measles virus (MV) infects immune cells located in the airways before spreading systemically, but the identity of these cells is unknown. To identify cells supporting primary MV infection, we took advantage of mice expressing the MV receptor human signaling lymphocyte activation molecule (SLAM, CD150) with human-like tissue specificity. We infected these mice intranasally (IN) with a wild-type MV expressing green fluorescent protein. One, t...
71 Citations Source Cite
G. Grant Welstead16
Estimated H-index: 16
(U of T: University of Toronto),
Caterina Iorio5
Estimated H-index: 5
(U of T: University of Toronto)
+ 5 AuthorsChristopher D. Richardson9
Estimated H-index: 9
(U of T: University of Toronto)
A transgenic mouse containing the complete human SLAM (hSLAM/CD150) gene, including its endogenous promoter for transcription, was generated by using human genomic DNA cloned into a bacterial artificial chromosome. hSLAM, the primary receptor for measles viruses (MV), was expressed on activated B, T, and dendritic cells with an expression profile equivalent to that of humans. We demonstrated that hSLAM+ cells obtained from the transgenic mouse, including activated B, T, and dendritic cells, were...
54 Citations Source Cite
Published on Aug 1, 2005in Cancer Research 9.13
Katsuya Tsuchihara4
Estimated H-index: 4
,
Valentina Lapin2
Estimated H-index: 2
+ 11 AuthorsMarees Harris-Brandts2
Estimated H-index: 2
We used DNA microarray screening to identify Ckap2 ( cytoskeleton associated protein 2 ) as a novel p53 target gene in a mouse erythroleukemia cell line. DNA damage induces human and mouse CKAP2 expression in a p53-dependent manner and p53 activates the Ckap2 promoter. Overexpressed Ckap2 colocalizes with and stabilizes microtubules. In p53-null cells, overexpression of Ckap2 induces tetraploidy with aberrant centrosome numbers, suggesting disturbed mitosis and cytokinesis. In p53-competent cell...
28 Citations Source Cite
Published on Jun 1, 2005in Journal of Virology 4.37
Joyce A. Wilson17
Estimated H-index: 17
,
Christopher D. Richardson27
Estimated H-index: 27
RNA interference represents an exciting new technology that could have therapeutic applications for the treatment of viral infections. Hepatitis C virus (HCV) is a major cause of chronic liver disease and affects over 270 million individuals worldwide. The HCV genome is a single-stranded RNA that functions as both an mRNA and a replication template, making it an attractive target for therapeutic approaches using short interfering RNA (siRNA). We have shown previously that double-stranded siRNA m...
173 Citations Source Cite
Published on Sep 15, 2004in Journal of Virology 4.37
G. Grant Welstead16
Estimated H-index: 16
(OICR: Ontario Institute for Cancer Research),
Eric C. Hsu3
Estimated H-index: 3
(OICR: Ontario Institute for Cancer Research)
+ 2 AuthorsChristopher D. Richardson27
Estimated H-index: 27
(OICR: Ontario Institute for Cancer Research)
Measles virus has been reported to enter host cells via either of two cellular receptors, CD46 and CD150 (SLAM). CD46 is found on most cells of higher primates, while SLAM is expressed on activated B, T, and dendritic cells and is an important regulatory molecule of the immune system. Previous reports have shown that measles virus can down regulate expression of its two cellular receptors on the host cell surface during infection. In this study, the process of down regulation of SLAM by measles ...
25 Citations Source Cite
Published on Aug 1, 2004in Journal of Cardiac Failure 3.94
Koichi Fuse2
Estimated H-index: 2
(U of T: University of Toronto),
Youan Liu8
Estimated H-index: 8
(U of T: University of Toronto)
+ 4 AuthorsPeter Liu82
Estimated H-index: 82
(U of T: University of Toronto)
Source Cite
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