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Christopher D. Richardson
Dalhousie University
97Publications
37H-index
5,527Citations
Publications 89
Newest
#1Chen Jei Tai (TMU: Taipei Medical University)H-Index: 4
#2Ching Hsuan Liu (TMU: Taipei Medical University)H-Index: 1
Last.Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 6
view all 7 authors...
Oncolytic virotherapy represents an emerging development in anticancer therapy. Although it has been tested against a variety of cancers, including breast cancer, the efficacy of oncolytic viral vectors delivered as a monotherapy is limited. Enhancing viral oncolytic therapies through combination treatment with anticancer agents is a feasible strategy. In this study, we considered a chemovirotherapeutic approach for treating breast adenocarcinoma using oncolytic measles virus (MV) and the chemot...
Source
#1Alagie JasseyH-Index: 3
#2Ching-Hsuan LiuH-Index: 1
Last.Liang-Tzung LinH-Index: 2
view all 6 authors...
Mitophagy is a selective form of autophagy, targeting damaged mitochondria for lysosomal degradation. Although HCV infection has been shown to induce mitophagy, the precise underlying mechanism and the effector protein responsible remain unclear. Herein, we demonstrated that the HCV non-structural protein 5A (NS5A) plays a key role in regulating cellular mitophagy. Specifically, the expression of HCV NS5A in the hepatoma cells triggered hallmarks of mitophagy including mitochondrial fragmentatio...
2 CitationsSource
#1Chien Ju LinH-Index: 1
#2Ching Hsuan Liu (TMU: Taipei Medical University)H-Index: 1
Last.Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 6
view all 7 authors...
AbstractCoxsackievirus A16 (CVA16) is an etiologic agent of hand, foot, and mouth disease (HFMD) that affects young children, and although typically self-limited, severe complications, and fatal ca...
1 CitationsSource
#1Nicholas van Buuren (Stanford University)H-Index: 10
#2Timothy L. Tellinghuisen (Scripps Research Institute)H-Index: 20
Last.Karla Kirkegaard (Stanford University)H-Index: 49
view all 4 authors...
Viruses are simple organisms that consist of genetic information and a few types of proteins. They cannot replicate on their own, and instead hijack the molecular machinery of a host cell to produce more of themselves. Inside an infected cell, the genetic information of the virus is replicated and ‘read’ to create viral proteins. These components are then assembled to form a new generation of viruses. During this process, genetic errors may occur that lead to modifications in the viral proteins,...
1 CitationsSource
#1Michael N. Ha (U of T: University of Toronto)H-Index: 2
#2Sebastien Delpeut (Dal: Dalhousie University)H-Index: 5
Last.Christopher D. Richardson (Dal: Dalhousie University)H-Index: 37
view all 10 authors...
4 CitationsSource
#1Ching Hsuan Liu (TMU: Taipei Medical University)H-Index: 3
#2Chun Ching Lin (KMU: Kaohsiung Medical University)H-Index: 22
Last.Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 6
view all 14 authors...
Objective Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome this limitation, we developed highly bioavailable silibinin nanoparticles (SB-NPs) and evaluated their efficiency against HCV infection. Design SB-NPs were prepared using a nanoemu...
11 CitationsSource
#1Sebastien Delpeut (Dal: Dalhousie University)H-Index: 5
#2Gary Sisson (Dal: Dalhousie University)H-Index: 17
Last.Christopher D. Richardson (Dal: Dalhousie University)H-Index: 37
view all 4 authors...
6 CitationsSource
#1Liang-Tzung LinH-Index: 2
#2Christopher D. Richardson (Dal: Dalhousie University)H-Index: 37
The hemagglutinin (H) protein of measles virus (MeV) interacts with a cellular receptor which constitutes the initial stage of infection. Binding of H to this host cell receptor subsequently triggers the F protein to activate fusion between virus and host plasma membranes. The search for MeV receptors began with vaccine/laboratory virus strains and evolved to more relevant receptors used by wild-type MeV. Vaccine or laboratory strains of measles virus have been adapted to grow in common cell lin...
18 CitationsSource
#1Chueh Yao Chung (KMU: Kaohsiung Medical University)H-Index: 5
#2Ching Hsuan Liu (TMU: Taipei Medical University)H-Index: 3
Last.Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 6
view all 13 authors...
Abstract Without a vaccine, hepatitis C virus (HCV) remains a global medical and socio-economic burden, predisposing about 170 million carriers worldwide to end-stage liver diseases including cirrhosis and hepatocellular carcinoma. Although the recently developed direct-acting antivirals (DAAs) have revolutionized hepatitis C treatment, most of them are unsuitable for monotherapy due to risks of resistance, thus necessitating combination with interferon (IFN)-alpha, ribavirin, or additional DAAs...
10 CitationsSource
#1Liang Tzung Lin (TMU: Taipei Medical University)H-Index: 6
#2Chueh Yao Chung (KMU: Kaohsiung Medical University)H-Index: 5
Last.Christopher D. Richardson (Dal: Dalhousie University)H-Index: 37
view all 13 authors...
1 CitationsSource
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