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Andrew M. Peters
University of Texas Health Science Center at Houston
6Publications
4H-index
95Citations
Publications 6
Newest
#1Zhen Zhou (WHU: Wuhan University)H-Index: 1
#2Andrew M. Peters (University of Texas Health Science Center at Houston)H-Index: 4
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 9 authors...
Objective— Pharmacological inhibition of the AT1R (angiotensin II type 1 receptor) with losartan can attenuate ascending aortic remodeling induced by transverse aortic constriction (TAC). In this s...
1 CitationsSource
Source
#1Jiyuan Chen (University of Texas Health Science Center at Houston)H-Index: 5
#2Andrew M. Peters (University of Texas Health Science Center at Houston)H-Index: 4
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 20 authors...
Rationale: Mutations in ACTA2 , encoding the smooth muscle isoform of α-actin, cause thoracic aortic aneurysms, acute aortic dissections, and occlusive vascular diseases. Objective: We sought to identify the mechanism by which loss of smooth muscle α-actin causes aortic disease. Methods and Results: Acta2 −/− mice have an increased number of elastic lamellae in the ascending aorta and progressive aortic root dilation as assessed by echocardiography that can be attenuated by treatment with losart...
16 CitationsSource
#1Jiyuan Chen (University of Texas Health Science Center at Houston)H-Index: 5
#2Andrew M. Peters (University of Texas Health Science Center at Houston)H-Index: 4
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 20 authors...
Rationale: Mutations in ACTA2, encoding the smooth muscle isoform of α-actin (SM α-actin), cause thoracic aortic aneurysms, acute aortic dissections, and occlusive vascular diseases. Objective: We sought to identify the mechanism by which loss of SM α-actin causes aortic disease. Methods and Results: Acta2 -/- mice have an increased number of elastic lamellae in the ascending aorta and progressive aortic root dilation as assessed by echocardiography that can be attenuated by treatment with losar...
11 CitationsSource
#1Shao Qing Kuang (University of Texas Health Science Center at Houston)H-Index: 7
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 23 authors...
The ascending thoracic aorta is designed to withstand biomechanical forces from pulsatile blood. Thoracic aortic aneurysms and acute aortic dissections (TAADs) occur as a result of genetically triggered defects in aortic structure and a dysfunctional response to these forces. Here, we describe mutations in the forkhead transcription factor FOXE3 that predispose mutation-bearing individuals to TAAD. We performed exome sequencing of a large family with multiple members with TAADs and identified a ...
35 CitationsSource
#1Shao Qing Kuang (University of Texas Health Science Center at Houston)H-Index: 7
#2Liang Geng (University of Texas Health Science Center at Houston)H-Index: 1
Last.Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 58
view all 10 authors...
Objective— Although hypertension is the most common risk factor for thoracic aortic diseases, it is not understood how increased pressures on the ascending aorta lead to aortic aneurysms. We investigated the role of angiotensin II type 1 receptor activation in ascending aortic remodeling in response to increased biomechanical forces using a transverse aortic constriction (TAC) mouse model. Approach and Results— Two weeks after TAC, the increased biomechanical pressures led to ascending aortic di...
32 CitationsSource
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