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Jacob M. Musser
Yale University
15Publications
6H-index
192Citations
Publications 15
Newest
Published on Sep 5, 2019in bioRxiv
Jacob Musser (EMBL-EBI: European Bioinformatics Institute), Klaske J. Schippers1
Estimated H-index: 1
(EMBL-EBI: European Bioinformatics Institute)
+ 24 AuthorsAna Hernández-Plaza1
Estimated H-index: 1
(UPM: Technical University of Madrid)
The evolutionary origin of metazoan cell types such as neurons, muscles, digestive, and immune cells, remains unsolved. Using whole-body single-cell RNA sequencing in a sponge, an animal without nervous system and musculature, we identify 18 distinct cell types comprising four major families. This includes nitric-oxide sensitive contractile cells, digestive cells active in macropinocytosis, and a family of amoeboid-neuroid cells involved in innate immunity. We uncover presynaptic genes in an amo...
Published on Jun 1, 2019in Current Opinion in Neurobiology6.01
Detlev Arendt45
Estimated H-index: 45
,
Paola Yanina Bertucci4
Estimated H-index: 4
+ 1 AuthorsJacob M. Musser6
Estimated H-index: 6
Major questions in the evolution of neurons and nervous systems remain unsolved, such as the origin of the first neuron, the possible convergent evolution of neuronal phenotypes, and the transition from a relatively simple decentralized nerve net to the complex, centralized nervous systems found in modern bilaterian animals. In recent years, comparative single-cell transcriptomics has opened up new research avenues addressing these issues. Here, we review recent conceptual progress toward an evo...
Constantin Pape4
Estimated H-index: 4
,
Alex Matskevych + 7 AuthorsAnna Kreshuk9
Estimated H-index: 9
The throughput of electron microscopes has increased significantly in recent years, enabling detailed analysis of cell morphology and ultrastructure. Analysis of neural circuits at single-synapse resolution remains the flagship target of this technique, but applications to cell and developmental biology are also starting to emerge at scale. The amount of data acquired in such studies makes manual instance segmentation, a fundamental step in many analysis pipelines, impossible. While automatic se...
Published on Jul 25, 2018in bioRxiv
Jacob M. Musser6
Estimated H-index: 6
(Yale University),
Günter P. Wagner61
Estimated H-index: 61
(Yale University)
+ 4 AuthorsRichard O. Prum46
Estimated H-index: 46
(Yale University)
Birds and other reptiles possess a diversity of feather and scale-like skin appendages. Feathers are commonly assumed to have originated from ancestral scales in theropod dinosaurs. However, most birds also have scaled feet, indicating birds evolved the capacity to grow both ancestral and derived morphologies. This suggests a more complex evolutionary history than a simple linear transition between feathers and scales. We set out to investigate the evolution of feathers via the comparison of tra...
Published on May 1, 2018in Molecular Biology and Evolution14.80
Kaia Achim10
Estimated H-index: 10
,
Nils Eling3
Estimated H-index: 3
(University of Cambridge)
+ 8 AuthorsJohn C. Marioni48
Estimated H-index: 48
(University of Cambridge)
Published on Feb 1, 2018in Genome Biology and Evolution3.73
Cong Liang2
Estimated H-index: 2
(Yale University),
Jacob M. Musser6
Estimated H-index: 6
(Yale University)
+ 2 AuthorsGünter P. Wagner61
Estimated H-index: 61
Published on Nov 1, 2017in Developmental Biology2.94
Jacob M. Musser6
Estimated H-index: 6
,
Detlev Arendt45
Estimated H-index: 45
Abstract Ciliary photoreceptors are a diverse cell type family that comprises the rods and cones of the retina and other related cell types such as pineal photoreceptors. Ciliary photoreceptor evolution has been dynamic during vertebrate evolution with numerous gains and losses of opsin and phototransduction genes, and changes in their expression. For example, early mammals lost all but two cone opsins, indicating loss of cone receptor types in response to nocturnal lifestyle. Our review focuses...
Published on Nov 1, 2017in Developmental Biology2.94
Gerhard Schlosser26
Estimated H-index: 26
,
Jacob M. Musser6
Estimated H-index: 6
,
Detlev Arendt45
Estimated H-index: 45
Published on Dec 1, 2016in Nature Reviews Genetics43.70
Detlev Arendt45
Estimated H-index: 45
(Heidelberg University),
Jacob M. Musser6
Estimated H-index: 6
+ 8 AuthorsManfred Dietrich Laubichler18
Estimated H-index: 18
(MPG: Max Planck Society)
In this article, the authors review the current understanding of the molecular mechanisms underlying cell type identity and discuss how new phenotypic features of cell types evolve. They explain how evolutionary lineage differs from developmental lineage and highlight how an evolutionary view of cell type identity can facilitate research in comparative cell biology.
Published on Aug 17, 2016in bioRxiv
Cong Liang2
Estimated H-index: 2
(Yale University),
Jacob M. Musser6
Estimated H-index: 6
(Yale University)
+ 2 AuthorsGünter P. Wagner61
Estimated H-index: 61
(Yale University)
Transcriptomic data yields valuable insights into cell type, tissue, and organ evolution. However, interpreting this data requires understanding how transcriptomes evolve. A particularly difficult problem is that cell type transcriptomes may not evolve independently. Here we present a statistical model to estimate the level of concerted transcriptome evolution and apply it to published and new data. The results indicate that tissues undergo pervasive concerted evolution in gene expression. Tissu...
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