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Takeshi Murai
Dainippon Sumitomo Pharma Co., Ltd.
11Publications
5H-index
86Citations
Publications 11
Newest
Abstract Antagonism of the dopamine D 3 receptor is considered a promising strategy for the treatment of cognitive impairment associated with schizophrenia. We have previously reported that the atypical antipsychotic blonanserin, a dopamine D 2 /D 3 and serotonin 5-HT 2A receptor antagonist, highly occupies dopamine D 3 receptors at its antipsychotic dose range in rats. In the present study, we evaluated the effects of blonanserin on executive function in common marmosets using the object retrie...
Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson’s disease and Tourette syndrome [1] ; [2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animal...
#1Shunsuke NakazawaH-Index: 2
#2Takeshi MuraiH-Index: 5
Last.Kazuhito IkedaH-Index: 6
view all 5 authors...
Rationale Growing evidence suggests that dopamine D4 receptors (D4Rs) are involved in controlling executive functions. We have previously demonstrated that Ro 10-5824, a D4R partial agonist, improves the performance of common marmosets in the object retrieval detour (ORD) task. However, the neural mechanisms underlying this improvement are unknown.
Abstract Previous pilot clinical studies have shown that the serotonin 5-HT 1A receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. In the present study, we evaluated the cognitive efficacy of tandospirone, given alone or in combination with the antipsychotic blonanserin, risperidone or haloperidol, on executive function in marmosets using the object retrieval with detour (ORD) task. Treatment with tandospirone alone at 20 and 40 mg/kg increase...
Abstract Infants with autism have difficulties performing joint visual attention (JVA), defined as following another person's pointing gesture and gaze. Some non-human primates (NHPs) can also perform JVA. Most preclinical research on autism spectrum disorders (ASD) has used rodents as animal models of this social interaction disorder. However, models using rodents fail to capture the complexity of social interactions that are disrupted in ASD. Therefore, JVA impairment in NHPs might be a more u...
#1Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
#2Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
Last.Mutsuo Taiji (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 24
view all 6 authors...
Abstract We previously demonstrated among several antipsychotics exhibiting potent dopamine D 2 receptor antagonism that only lurasidone, (1R,2S,3R,4S)- N -[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinylmethyl]-1-cyclohexylmethyl]-2,3-bicyclo[2.2.1] heptanedicarboximide hydrochloride, improved performance in the object retrieval detour (ORD) task by marmosets. The mechanisms by which only lurasidone causes enhancements in cognitive function have not yet been established; however, most anti...
Abstract. Patients with psychiatric disorders, including schizophrenia, are reported to suffer from sleep disorders. In this study, we investigated the effects of lurasidone, an atypical antipsychotic, on sleep architecture in rats using sleep electroencephalography. The course of sleep in rats was classified into 3 stages: WAKE, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. Lurasidone shortened REM duration and prolonged the mean duration of one bout in WAKE and NREM....
#1Tomokazu Nakako (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 7
#2Takeshi Murai (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 5
Last.Kazuhito Ikeda (Dainippon Sumitomo Pharma Co., Ltd.)H-Index: 6
view all 6 authors...
Abstract It is considered that functional deficiency of the NMDA receptors in the prefrontal cortex (PFC) is one of the causes of the cognitive impairment observed in schizophrenia. As non-human primates display more developed PFC than rodents, they are considered to be useful experimental animals for improving the predictive validity of models used to discover new drugs for treating cognitive dysfunction. The aim of this study was to develop a convenient model of the cognitive impairment observ...
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