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Guo-Hua Bi
National Institute on Drug Abuse
EndocrinologyNucleus accumbensCannabinoidOpioidAddiction
13Publications
4H-index
48Citations
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Publications 20
Newest
#1Guo-Hua Bi (NIDA: National Institute on Drug Abuse)H-Index: 4
#2Ewa Galaj (NIDA: National Institute on Drug Abuse)H-Index: 2
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 4
view all 4 authors...
: A growing number of studies suggest therapeutic applications of cannabidiol (CBD), a recently U.S. Food and Drug Administration (FDA)-approved medication for epilepsy, in treatment of many other neuropsychological disorders. However, pharmacological action and the mechanisms by which CBD exerts its effects are not fully understood. Here, we examined the effects of CBD on oral sucrose self-administration in rodents and explored the receptor mechanisms underlying CBD-induced behavioral effects u...
6 CitationsSource
#1Ewa Galaj (NIDA: National Institute on Drug Abuse)H-Index: 2
#2Guo-Hua Bi (NIDA: National Institute on Drug Abuse)H-Index: 4
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 4
view all 4 authors...
Abstract Cocaine abuse continues to be a serious health problem worldwide. Despite intense research there is currently no FDA-approved medication to treat cocaine use disorder. The recent search has been focused on agents targeting primarily the dopamine system, while limited success has been achieved at the clinical level. Cannabidiol (CBD) is a U.S. FDA-approved cannabinoid for the treatment of epilepsy and recently was reported to have therapeutic potential for other disorders. Here we system...
6 CitationsSource
#1Yi He (NIDA: National Institute on Drug Abuse)H-Index: 6
#1Yi He (University of Pittsburgh)
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
view all 6 authors...
BACKGROUND AND PURPOSE: beta-Caryophyllene (BCP) is a plant-derived terpenoid used as a food additive for many decades. Recent studies indicate that BCP is a cannabinoid CB2 receptor agonist with medical benefits for a number of human diseases. However, little is known about its therapeutic potential for drug abuse and addiction. EXPERIMENT APPROACH: We used pharmacological, transgenic, and optogenetic approaches to systematically evaluate the effects of BCP on nicotine-taking and nicotine-seeki...
1 CitationsSource
#1Maddalena Mereu (NIDA: National Institute on Drug Abuse)H-Index: 15
#2Takato Hiranita (UF: University of Florida)
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
view all 13 authors...
Modafinil and methylphenidate are medications that inhibit the neuronal reuptake of dopamine, a mechanism shared with cocaine. Their use as “smart drugs” by healthy subjects poses health concerns and requires investigation. We show that methylphenidate, but not modafinil, maintained intravenous self-administration in Sprague-Dawley rats similar to cocaine. Both modafinil and methylphenidate pretreatments potentiated cocaine self-administration. Cocaine, at self-administered doses, stimulated mes...
Source
#1Xiao Fei Wang (NIDA: National Institute on Drug Abuse)H-Index: 2
#2Ewa Galaj (NIDA: National Institute on Drug Abuse)H-Index: 2
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
view all 9 authors...
BACKGROUND AND PURPOSE: Cannabis or cannabinoids produce characteristic tetrad effects-analgesia, hypothermia, catalepsy and suppressed locomotion, which are believed to be mediated by the activation of cannabinoid CB1 receptors. Given recent findings of CB2 and GPR55 receptors in the brain, we examined whether these receptors are also involved in cannabinoid action. EXPERIMENTAL APPROACH: We compared Delta(9) -tetrahydrocannabinol (Delta(9) -THC)-, WIN55212-2-, or XLR11-induced tetrad effects b...
2 CitationsSource
#1Ewa Galaj (NIDA: National Institute on Drug Abuse)H-Index: 2
#2Guo-Hua Bi (NIDA: National Institute on Drug Abuse)H-Index: 4
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
view all 4 authors...
Source
#1Gianluigi TandaH-Index: 47
#2Maddalena MereuH-Index: 15
Last. Jacqueline D. KeighronH-Index: 8
view all 13 authors...
Source
#1Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
#2Pretal P. Muldoon (VCU: Virginia Commonwealth University)H-Index: 13
Last. Eliot L. Gardner (NIDA: National Institute on Drug Abuse)H-Index: 51
view all 8 authors...
BACKGROUND AND PURPOSE: Both types of cannabinoid receptors-CB1 and CB2 -regulate brain functions relating to addictive drug-induced reward and relapse. CB1 receptor antagonists and CB2 receptor agonists have anti-addiction efficacy, in animal models, against a broad range of addictive drugs. Δ9 -Tetrahydrocannabivarin (Δ9 -THCV)-a cannabis constituent-acts as a CB1 antagonist and a CB2 agonist. Δ8 -Tetrahydrocannabivarin (Δ8 -THCV) is a Δ9 -THCV analogue with similar combined CB1 antagonist/CB2...
1 CitationsSource
#1Chloe J. Jordan (NIDA: National Institute on Drug Abuse)H-Index: 9
#2Bree A Humburg (NIDA: National Institute on Drug Abuse)H-Index: 1
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
view all 13 authors...
Abstract Prescription opioid abuse is a global crisis. New treatment strategies for pain and opioid use disorders are urgently required. We evaluated the effects of R-VK4-40, a highly selective dopamine (DA) D3 receptor (D3R) antagonist, on the rewarding and analgesic effects of oxycodone, the most commonly abused prescription opioid, in rats and mice. Systemic administration of R-VK4-40 dose-dependently inhibited oxycodone self-administration and shifted oxycodone dose-response curves downward ...
1 CitationsSource
#1Krista Spiller (UPenn: University of Pennsylvania)H-Index: 15
#2Guo-Hua Bi (NIDA: National Institute on Drug Abuse)H-Index: 4
Last. Zheng-Xiong Xi (NIDA: National Institute on Drug Abuse)H-Index: 42
view all 6 authors...
BACKGROUND AND PURPOSE: Endocannabinoids are critically involved in brain reward functions, mediated by activation of CB1 receptors, reflecting their high density in the brain. However, the recent discovery of CB2 receptors in the brain, particularly in the midbrain dopamine neurons, has challenged this view and inspired us to re-examine the roles of both CB1 and CB2 receptors in the effects of cannabis. EXPERIMENTAL APPROACH: In the present study, we used the electrical intracranial self-stimul...
6 CitationsSource
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